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Pirooz Zareie

@pzareie.bsky.social

26 followers 29 following 3 posts

Posts Replies Media

Pirooz Zareie @pzareie.bsky.social · 08/05/2025

Excited to share our review on the vital role of skin-resident T cells in protecting the body’s largest barrier organ. We explore their contributions to immune surveillance, tissue homeostasis, and skin disease. Check it out! www.nature.com/articles/s41... @danhkaplan.bsky.social @LMackayLab

Cutaneous T cell immunity - Nature Immunology

In this Review, the authors discuss the latest in skin immunology research with a special focus on the role of skin-resident T cells.

Pirooz Zareie @pzareie.bsky.social · 22/02/2025

Check out our new paper!

Reposted by Pirooz Zareie

Seth Thomas Scanlon @immunoeditor.bsky.social · 21/02/2025

Now in #Science #Immunology: Justin Zhang, Jamie Rossjohn, @pzareie.bsky.social, @niclag.bsky.social, & al. generate LCK-FREE mice expressing mutated form of endogenous LCK that cannot bind to #CD4 or #CD8. These animals show defects in #TCell lineage fidelity & antigen-specific #TCR diversity!

LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity

LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.