Background Evaluating the relationship between glucocorticoid (GC) exposure and organ damage in systemic lupus erythematosus (SLE) is challenging since GC dose varies over time. It is unclear which ...

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16-year-old Anna Foster was diagnosed with lupus

In photosensitive lupus, dysregulated cutaneous UV responses recruit and activate monocyte-derived dendritic cells that may drive lesion development.

The prognostic value of achieving the European League Against Rheumatism (EULAR) 3- and 6-month treatment targets in lupus nephritis (LN) remains uncertain.

Researchers hope to shed light on conditions such as schizophrenia, epilepsy, cerebral palsy, intellectual disability and rare forms of dementia Researchers have created mice with half-human brains in an effort to understand and develop new treatments for disorders such as schizophrenia, epilepsy, cerebral palsy, intellectual disability and rare forms of dementia. The scientists transplanted lab-grown human brain cells into animals that were engineered to be born without a cortex or hippocampus. This made space for the human tissue to grow inside the rodents’ skulls. Continue reading...

Objectives. Despite promising advances in metabolomics for biomarker discovery in systemic lupus erythematosus (SLE), studies examining associations with det...

Researchers discovered how a common lupus risk variant may boost antiviral defenses while increasing autoimmunity risk.

Virolainen et al. combine human genetics, functional genomics, and mouse models to show that a common lupus-risk IRF7 haplotype enhances IRF7 nuclear localization, DNA binding, and type I interferon production. The haplotype improves antiviral defense but increases autoreactivity, revealing an evolutionary trade-off between host protection and autoimmunity.

A real-world study revealed little difference in 12-month renal response rates among immunosuppressive regimens for patients with first-onset PLMN.

Medication nonadherence in systemic lupus erythematosus is highest among younger adults facing access and scheduling barriers.

Researchers worry that generative AI is homogenizing culture and cognition.

A single-cell transcriptomic atlas identified stromal and immune populations in renal tissue associated with lupus nephritis disease activity.

Clinical practice guidelines are fundamental to evidence-based care. However, their current development, based on infrequent systematic reviews, is increasingly challenged by the rapid expansion of th...

Childhood-onset systemic lupus erythematosus (cSLE) is a severe autoimmune disease with significant morbidity and enhanced type I interferon (IFN-I) signalling, potentially contributing to its aggress...

Childhood-onset SLE (cSLE) is often described as more severe than adult-onset disease (aSLE) based largely on cross-sectional studies. We examined differences in disease characteristics, medication…