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cryo-em.bsky.social

@cryo-em.bsky.social
112 followers 42 following 11 posts
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Przemek Dutka @przemekdut.bsky.social · 21h
Our latest development is now on bioRxiv: cryoSHIELDs — amphipathic peptide additives that make cryo-EM grid prep far more reliable. Tested across 24 protein systems, they enabled the first ABCC6 structure and GPCR–G protein structures at just 0.1–0.5 mg/mL! www.biorxiv.org/content/10.6...
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Rémi Fronzes @fronzeslab.bsky.social · 29/09/2026
CryoFIB SEM installed at the @bic-bordeaux.bsky.social 🍾🎉🍾🎉
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Nature Methods @natmethods.nature.com · 02/10/2026
Graphene reservoirs formed over perforated support films precisely control ice thickness during cryo-EM sample preparation. www.nature.com/articles/s41...
nature.com
Control of ice thickness in cryo-EM via confinement - Nature Methods
This study explores the use of graphene reservoirs formed over perforated supporting films as a method to precisely control ice thickness during cryo-EM sample preparation.
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bioRxivpreprint @biorxivpreprint.bsky.social · 05/10/2026
Plunge freezing tweezers with ultrasonic excitation for reducing preferred particle orientation in cryo-EM www.biorxiv.org/content/10.64898/20…
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cryoEM papers @cryoempapers.bsky.social · 02/10/2026
Cryo-tides: synthetic peptides for cryo-EM grid preparation of multi-subunit protein complexes sensitive to the air-water interface www.biorxiv.org/content/10.64898/2026.09.30.755610v1 #cryoEM
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Structural Biology @actacrystd.iucr.org · 08/10/2026
LowDoseWizard addresses a practical limitation of routine cryo-TEM operation by reducing the setup of low-dose imaging conditions to a guided and standardized workflow implemented in SerialEM #LowDoseImaging #SerialEM #CryoEM doi.org/10.1107/S205...
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Beckmann Lab @beckmannlab.bsky.social · 23/09/2026
Frank Nijpels from VitriMatics paid us a visit today. Not only did he repair our broken VitroBot Mark IV and returned it in person, he also brought some extremely cool tools ❄️ for reliable cryo-EM grid freezing 🔬. Check out the VitriClip and the SupraBlot at vitrimatics.com. #cryoEM #cryoET
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Hopfner Lab @hopfnerlab.bsky.social · 24/09/2026
A new member has arrived in the institute! 🎉🔬Our new Aquilos 2 cryo-FIB has made it to our cryoEM facility! We are very excited to add this powerful technology to our structural biology toolbox. 🧊#ElectronMicroscopy @katja-lammens.bsky.social @genecenter-lmu.bsky.social @nucleate-cluster.bsky.social
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Nature Methods @natmethods.nature.com · 22/09/2026
MemBrain v2: streamlined analysis of membranes in cryo-ET with tools for membrane segmentation, protein localization and spatial analysis. www.nature.com/articles/s41...
nature.com
MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography - Nature Methods
MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...
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eurobioimaging.bsky.social @eurobioimaging.bsky.social · 23/09/2026
#VirtualPub We are delighted to welcome Simone Mattei, EMBL Imaging Centre, for a talk on "Targeted cryo-Serial Lift Out for cellular structural biology."  🗓️ Friday, September 25 @ 13:00 CEST Register⤵️ www.eurobioimaging.eu/events/seria...
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Structura Biotechnology @structurabio.bsky.social · 23/09/2026
🔎 A classic #cryoEM particle curation conundrum: 2D or 3D classification? "Decoy Classification" using Heterogeneous Refinement in #CryoSPARC curates particles directly in 3D, helping remove junk particles while preserving valuable views. Read more in the CryoSPARC Blog 👉 bit.ly/3SXfwS0
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Casper Berger @casperberger.bsky.social · 23/09/2026
We developed Adaptive Polishing for the consistent preparation of ~150 nm thin FIB-lamellae. This was done by using imaging feedback to adjust parameters for each lamella, or Adaptive Milling, rather than applying a fixed recipe. Preprint: doi.org/10.64898/202...
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Structural Biology @actacrystd.iucr.org · 22/09/2026
SURFER is a lightweight, GPU-accelerated extension for UCSF ChimeraX that enables rapid semantic differentiation of membrane or membrane-mimic density from macromolecular signal #CryoEM #Segmentation #Membrane doi.org/10.1107/S205...
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bioRxivpreprint @biorxivpreprint.bsky.social · 17/09/2026
The CAHRA Challenge: A Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms www.biorxiv.org/content/10.64898/20…
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Simons Foundation @simonsfoundation.org · 18/09/2026
We're continuing to advance cryo-EM and related technologies in disciplines such as structural biology, biochemistry and medical science. Read more about our work: bit.ly/3UZY2ow #science #biology
bit.ly
Beyond the Cryo-EM Resolution Revolution
Beyond the Cryo-EM Resolution Revolution on Simons Foundation
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Brian D. Wade @astrobrian.bsky.social · 18/09/2026
When a laser beam hits an electron beam #microscopy #ElectronMicroscopy #cryoEM #cryoET #microSky #scienceSky www.nature.com/articles/s41...
nature.com
When a laser beam hits an electron beam - Nature Methods
Prototypes of specially engineered transmission electron microscopes deliver images with greatly improved contrast to cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) projects...
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SBGrid Consortium @sbgrid.bsky.social · 07/09/2026
Our software webinar series will resume in October with Beata Turoňová, Group Leader at the @mpibp.bsky.social, introducing cryoCAT. Until then, you can catch up on webinars you missed from our last series on the SBGrid YouTube channel. More here: buff.ly/p1w3J7S #SBGrid #Webinars
youtube.com
SBGrid Consortium
For structural biologists, by structural biologists! The SBGrid TV channel was developed with participation from many members of the structural biology community. We welcome suggestions for topics to…
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simon-alkema.bsky.social @simon-alkema.bsky.social · 17/09/2026
Releasing TOMATO, the TOMogram Annotation TOol! A lightweight Python GUI for going through hundreds of cryo-ET tomograms. Flag what's in each one, grade its quality, and end up with a table you can filter and act on. github.com/alkemasimon/...
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SBGrid Consortium @sbgrid.bsky.social · 15/09/2026
New Title Alert: OCTOPI- is a deep-learning framework for automated 3D particle picking in cryo-electron tomography, with tools for training and running 3D U-Net models and automatically exploring model configurations. More here: buff.ly/WXgAVEN #SBGrid #Software
github.com
GitHub - Biohub/octopi: Search for Protein 3D Coordinates in CryoET Tomograms
Search for Protein 3D Coordinates in CryoET Tomograms - Biohub/octopi
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cryoEM papers @cryoempapers.bsky.social · 10/09/2026
Cryoprotectants-assisted plunge freezing of thick brain tissue specimens for targeted physiologically relevant cryo-imaging in situ pubmed.ncbi.nlm.nih.gov/42716017/ #cryoEM
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cryoEM papers @cryoempapers.bsky.social · 11/09/2026
CryoConvNeXt enables robust identification of low-abundance molecular species in experimental cryo-EM data www.biorxiv.org/content/10.64898/2026.09.08.750038v1 #cryoEM
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Lorna Malone @drlornamalone.bsky.social · 11/09/2026
Online registration is still open for the Wellcome–MRC in situ Cryo-ET Workshop 2026! 🦠🔬 📅 28 Sept – 02 Oct 2026 📍 @diamondlightsource.bsky.social & @astburycentre.bsky.social 💻 Hybrid stream available via Zoom 🔗Learn more and register: shorturl.at/LRihg #CryoET #CryoEM #StructuralBiology
shorturl.at
Wellcome-MRC in situ Cryo-ET Workshop 2026 - - Diamond Light Source
eBIC (Diamond light source) has partnered with the Astbury Biostructure Lab (University of Leeds), the Scottish Centre for Macromolecular Imaging (University of Glasgow), Midlands Regional Cryo-EM Fac...
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cryoEM papers @cryoempapers.bsky.social · 04/09/2026
A discussion of cryo-EM terminology as the outreach and number of PDB entries expand pubmed.ncbi.nlm.nih.gov/42689445/ #cryoEM
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cryoEM papers @cryoempapers.bsky.social · 04/09/2026
MOSAIC: A flexible, software-agnostic workflow for montage cryo-ET pubmed.ncbi.nlm.nih.gov/42691981/ #cryoEM
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TJ McCorvie @allostericstate.bsky.social · 07/09/2026
Registration for the Northern Structural Biology Meeting 2026 is now open! A great day of cryo-EM, X-ray crystallography, integrative structural biology and protein science. Come along to share your work, meet colleagues and make new connections! #StructuralBiology #CryoEM
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cryoEM papers @cryoempapers.bsky.social · 03/09/2026
Post-acquisition super resolution for cryo-electron microscopy pubmed.ncbi.nlm.nih.gov/42683649/ #cryoEM
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Instruct-ERIC @instruct-eric.bsky.social · 30/08/2026
Instruct.SI CryoEM Workshop 2026, Single Particle Analysis 📅 10 – 12 November 2026 📍 National Institute of Chemistry, Ljubljana, Slovenia. 📝 Registration Open| Deadline: 2 October 2026 🔗 instruct-eric.org/events/instr...
instruct-eric.org
Instruct.SI CryoEM Workshop 2026, Single Particle Analysis
<p>Cryo-EM Workshop on Single Particle Analysis (SPA) is based on the very positive response to the Basics of Methodological Approaches in Structural Biology workshop in 2024 and the and Instruct.SI…
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cryoEM papers @cryoempapers.bsky.social · 30/08/2026
Characterization of energy filtering slit widths for MicroED data collection pubmed.ncbi.nlm.nih.gov/42667085/ #cryoEM
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 28/08/2026
Imaging large fields-of-view at high resolution in cryo-ET with square beam montaging www.biorxiv.org/content/10.64898/20…
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cryoEM papers @cryoempapers.bsky.social · 28/08/2026
Comparative assessment of crystallographic and cryo-EM models in the Protein Data Bank pubmed.ncbi.nlm.nih.gov/42644567/ #cryoEM
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Structura Biotechnology @structurabio.bsky.social · 27/08/2026
🛠️ Even the most carefully managed IT environments need to be prepared for the unexpected. In #CryoSPARC v5, we introduced Instance Recovery, a built-in recovery system for unforeseen database loss or corruption, adding another layer of resilience to our #cryoEM software. Read more 👉 bit.ly/4xlZMGS
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Sonja Welsch @sonjawelsch.bsky.social · 26/08/2026
🤷🏻‍♀️ Idk why I have two Autoloader parts left over from this cryoEM build. Should keep them as spare parts I guess.
A completed plastic brick model of an electron microscope, but two extra bricks are left over.
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cryoEM papers @cryoempapers.bsky.social · 25/08/2026
Optimising the tilt increment for in situ cryo-electron tomography pubmed.ncbi.nlm.nih.gov/42636038/ #cryoEM
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Nature Methods @natmethods.nature.com · 25/08/2026
Protein nanocrates help address the air-water interface problem in cryo-EM-based protein structure determination. www.nature.com/articles/s41...
nature.com
Overcoming air–water interface-induced artifacts in cryo-EM with protein nanocrates - Nature Methods
MS2 bacteriophage-derived protein shells called ‘nanocrates’ help address the air–water interface-induced artifacts in cryo-EM structure determination by encapsulating target proteins and enabling the...
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Structural Biology @actacrystd.iucr.org · 24/08/2026
AlignPCA-2D is a principal component analysis-space Euclidean vector alignment method for fast, interpretable 2D classification in cryo-EM #3DReconstructionAndImageProcessing #SingleParticleCryoEM doi.org/10.1107/S205...
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Schiracha (Schirra) @schiracha.bsky.social · 24/08/2026
#cryoEM #cryoET #teamTOMO #Relion ❄️🔬 #IMOD / DeepETPicker style picks visualizer. You can use this little applet to open tomograms (or as a rudimentary volume viewer) right inside the interface. You can't edit picks here, but that might be something I add. I plan to #supportLT along side Relion
Relion software Web GUI
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MiTeGen @mitegen.com · 24/08/2026
Available now -> Graphene-coated R1.2/1.3 Quantifoil on 300 Mesh Gold Supports for your #cryoem research - This grid enables high-resolution data collection even for samples that are fragile, low concentration, or prone to preferred orientations -> zurl.co/7XOBv
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Edward T Eng @edwardteng.bsky.social · 21/08/2026
The next #CryoEM Current Practices Webinar will be a career panel with former users and trainees of the nIH sponsored national cryoEM service centers 8/27/2026 at 12 PM ET / 9AM PT Registration is at no-cost, but sign-up is required: us02web.zoom.us/webinar/regi...
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cryoEM papers @cryoempapers.bsky.social · 15/08/2026
Beyond cultured cells: Frontiers in in situ structural biology pubmed.ncbi.nlm.nih.gov/42594594/ #cryoEM
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Structura Biotechnology @structurabio.bsky.social · 17/08/2026
🚀 Preprint alert: cFAR and Relative Signal: Diagnosing Preferred Orientation in Single-Particle #CryoEM Explore how cFAR, tFAR, and Relative Signal provide complementary diagnostics for preferred orientation, tested across 14 #EMPIAR datasets and compared with established metrics 👉 bit.ly/4wBY1Ev
cFAR and Relative Signal: Diagnosing Preferred Orientation in Single-Particle CryoEM
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Matt Johnson @drmatthewcjohnson.bsky.social · 11/08/2026
Interested in a career in industry cryoEM? We're hiring! We seek a cryoEM/cryoET expert to join our team at Genentech advance our mission to provide high-resolution structural insights into biological macromolecules involved in health and disease. Apply at: careers.gene.com/us/en/job/20...
careers.gene.com
Systems Specialist II in South San Francisco, California, United States of America | Manufacturing & Engineering at Genentech
Apply for Systems Specialist II job with Genentech in South San Francisco, California, United States of America. Manufacturing & Engineering at Genentech
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cryoEM papers @cryoempapers.bsky.social · 12/08/2026
Direct deposition on pre-cooled grids: a new approach to sub-millisecond cryoEM grid preparation pubmed.ncbi.nlm.nih.gov/42579337/ #cryoEM
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Instruct-ERIC @instruct-eric.bsky.social · 10/08/2026
In situ Cryo-ET Workshop September/October 2026 📅 28 September – 2 October 2026 📍 Harwell Campus (Diamond Light Source) / Astbury Biostructure Laboratory (University of Leeds) / Online 📝 Registration Open 🔗Link below
instruct-eric.org
In situ Cryo-ET Workshop September/October 2026
<p><strong>In situ Cryo-ET Workshop 2026</strong> is part of the Wellcome/MRC-funded cryo-EM training programme. The course is aimed at students, and postdoctoral researchers who plan to use…
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cryoEM papers @cryoempapers.bsky.social · 09/08/2026
Integrating multitemperature sample preparation with particle rebalancing addresses preferred orientation pubmed.ncbi.nlm.nih.gov/42568763/ #cryoEM
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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 06/08/2026
CryoLigATE: enhancing the resolvability of cryo-EM maps in protein-ligand complexes using deep learning www.biorxiv.org/content/10.64898/20…
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cryoEM papers @cryoempapers.bsky.social · 05/08/2026
CsMT: a robust and streamlined CryoSPARC workflow for cryo-EM reconstruction of microtubules www.biorxiv.org/content/10.64898/2026.07.31.741890v1 #cryoEM
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SBGrid Consortium @sbgrid.bsky.social · 04/08/2026
New Title Alert: warpylib- is a Python library replicating core functionality from [WarpLib](buff.ly/t1bv8gU), a C# framework for cryo-electron tomography (cryo-ET) data processing. Built on PyTorch for GPU acceleration and automatic differentiation. More here: buff.ly/j81TW5L #SBGrid #Software
buff.ly
GitHub - warpem/warp
Contribute to warpem/warp development by creating an account on GitHub.
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Mart So-Last @mgflast.bsky.social · 31/07/2026
Made a little plugin for cryoEM map subboxing in ChimeraX: github.com/mgflast/Chim...
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cryoEM papers @cryoempapers.bsky.social · 02/08/2026
Advancing bacterial cell biology with in-cell cryo-electron microscopy pubmed.ncbi.nlm.nih.gov/42541890/ #cryoEM
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cryoEM papers @cryoempapers.bsky.social · 29/07/2026
An unattended image-processing pipeline for on-the-fly quality assessment and 3D exploration in cryo-EM pubmed.ncbi.nlm.nih.gov/42517196/ #cryoEM
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