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Pío Sierra

@piosierra.bsky.social
227 followers 145 following 47 posts

Research Assistant at University of Cambridge. Mobile DNA, pangenomes, things that evolve. Investigador en la Universidad de Cambridge. ADN móvil, pangenomas, cosas que evolucionan.

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Reposted by Pío Sierra
Emília Santos @emiliapsantos.bsky.social · 14/07/2026
🎨 job alert 🐠 Come join us! We have two positions open! These are part of our @erc.europa.eu funded project on the mechanisms underpinning convergence of colour patterns in cichlid fishes! Closing date: 16th August. Postdoc: www.cam.ac.uk/jobs/researc... Technician: www.cam.ac.uk/jobs/researc...
static.klipy.com
Callipterus Cichlid Collecting Shell
ALT: Callipterus Cichlid Collecting Shell
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Pío Sierra @piosierra.bsky.social · 25/06/2026
Excellent news for the Transposable Elements research community. Congratulations to everyone who made this possible. #Dfam #Repbase link.springer.com/article/10.1...
link.springer.com
Unifying Repbase and Dfam: a new open foundation for transposable element research - Mobile DNA
Repbase and Dfam, the two foundational resources for transposable element annotation, are being unified into a single, fully open access framework, with Repbase released under CC-0 and its core curati...
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Kevin Stevens @neohibolites.bsky.social · 18/06/2026
🐟🧪
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RepeatMasker Project @repeatmasker.bsky.social · 11/06/2026
A new RepeatModeler release is available. It adds compatibility with RepeatMasker 4.2.4 and the Dfam 4.0 FamDB format. TETools containers have also been updated with the latest RepeatMasker, RepeatModeler, and FamDB releases. See repeatmasker.org for details
repeatmasker.org
RepeatMasker Home Page
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Department of Genetics, University of Cambridge @geneticscam.bsky.social · 09/06/2026
Department of Genetics is hiring a Research Associate (Fixed Term) Details on how to apply: www.cam.ac.uk/jobs/researc...
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Department of Genetics, University of Cambridge @geneticscam.bsky.social · 10/12/2025
The Department of Genetics at the University of Cambridge is seeking a talented Postdoctoral Research Associate to work in the group of Dr Felipe Karam Teixeira (www.gen.cam.ac.uk/research-gro...) ➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...
cam.ac.uk
Postdoctoral Research Associate (Fixed Term)
Applications are invited for a Postdoctoral Research Associate position to work in the group of Dr Felipe Karam Teixeira (https://www.gen.cam.ac.uk/research-groups/research-groups/karam-teixeira) in
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Ian Henderson @hendersi.bsky.social · 27/11/2025
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity www.science.org/doi/10.1126/... @levine-lab.bsky.social very cool work
science.org
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
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Artem Ilin @adc34.bsky.social · 21/09/2025
Kicked off a series on #Drosophila TE discovery and naming. The first post covers elements that predate the term "mobile element", and more. artemilin.dev/posts/te_nam...
artemilin.dev
Drosophila TE name origins, Part 1 – Postdoc Postpunk
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Rayan Chikhi @rayanchikhi.bsky.social · 03/09/2025
🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024...
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Pío Sierra @piosierra.bsky.social · 29/07/2025
This is really cool!
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Pío Sierra @piosierra.bsky.social · 24/07/2025
So true.
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Department of Genetics, University of Cambridge @geneticscam.bsky.social · 17/06/2025
Ever wonder how nature got so diverse? The secret might lie in these colorful cichlid fish 🐠 Cambridge scientists discovered that ‘flipped’ segments of DNA act like evolutionary turbo boosts — helping species adapt fast and evolve into new ones. 👇 www.science.org/doi/10.1126/science.adr9961
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Kevin Stevens @neohibolites.bsky.social · 27/05/2025
What do we know about the earliest history of cichlid fishes? Here’s an extended and updated English version of my article on the biogeography and early evolution of cichlids, which I originally published in German in 2020. 🐟 🧪 #cichlid #biogeography #paleontology cichlidae.com/article.php?...
cichlidae.com
Biogeography, evolution, and ecology of the ancestral cichlids
This article examines the early evolution and biogeography of cichlids, discussing fossil evidence and the hypotheses regarding their origins. It reviews the debate between Gondwanan vicariance and ma...
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Corina Brussaard @brussaard7.bsky.social · 12/04/2025
Latest findings on cryptic infection of giant viruses published in @ScienceMagazine. We discovered a large virus hiding within a green algal genome producing virions. www.science.org/doi/10.1126/...
science.org
Cryptic infection of a giant virus in a unicellular green alga
Latency is a common strategy in a wide range of viral lineages, but its prevalence in giant viruses remains unknown. Here we describe a 617 kbp integrated giant viral element in the model green alga C...
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Sternberg Lab @sternberglab.bsky.social · 15/05/2025
1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...
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Pío Sierra @piosierra.bsky.social · 16/05/2025
🚨 🐟🐠 🚨
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Human Pangenome Reference Consortium @humanpangenome.bsky.social · 12/05/2025
📢 HPRC Release 2 is here! Now with phased genomes from 200+ individuals, a 5x increase from Release 1. Explore sequencing data, assemblies, annotations & alignments in our interactive data explorer ⬇️: humanpangenome.org/hprc-data-re...
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Nadav Ahituv @nadavahituv.bsky.social · 09/05/2025
Massively parallel jumping assay (MPJA) enables to test the jumping potential of thousands of transposons. Analysis of >160,000 Alu haplotypes identified transposition-asssociated domains. Amazing work by Navneet Matharu, Jingjing Zhao, Martin Kircher and many others. www.nature.com/articles/s41...
nature.com
Massively parallel jumping assay decodes Alu retrotransposition activity - Nature Communications
Here, the authors develop a high-throughput assay to measure the jumping potential of thousands of transposons in parallel.
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Pío Sierra @piosierra.bsky.social · 02/05/2025
A new result with Teratorns involved. 150Kb!
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Pío Sierra @piosierra.bsky.social · 30/04/2025
"Essential components of the genome", indeed.
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Pío Sierra @piosierra.bsky.social · 25/04/2025
😍 communities.springernature.com/posts/celebr...
communities.springernature.com
Celebrating DNA Day with transposable elements
Each year on DNA Day, we celebrate the DNA double helix structure and the Human Genome Project's completion. Here we dive into a fascinating genomic component: transposable elements. Once seen as mere...
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Pío Sierra @piosierra.bsky.social · 10/04/2025
This is a such a great work! So many things to find out now that we start having complete™ genomes.
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Marion Talbi @mariontalbi.bsky.social · 14/03/2025
I’m very proud and happy to share the first paper of my PhD with @millanek.bsky.social that is now published in the latest issue of the journal Evolution @journal-evo.bsky.social. academic.oup.com/evolut/artic...
academic.oup.com
Rapid evolution of recombination landscapes during the divergence of cichlid ecotypes in Lake Masoko
Abstract. Variation of recombination rate along the genome is of crucial importance to rapid adaptation and organismal diversification. Many unknowns remai
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Pío Sierra @piosierra.bsky.social · 18/03/2025
Pretty much sums up all my concerns, genetic and computational. 😅 xkcd.com
xkcd.com
Lungfish
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Pío Sierra @piosierra.bsky.social · 18/03/2025
I was so much looking for this after I saw her presenting it last year. Great story!
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Alex Cagan @atjcagan.bsky.social · 17/03/2025
An excellent postdoc opportunity with Adrian Baez-Ortega at the University of Cambridge on the genomics of transmissible cancer. Adrian is a brilliant scientist and mentor, this is a fantastic opportunity I strongly recommend.
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Vincent Burrus 🇨🇦💙💛 @vincentburrus.bsky.social · 11/03/2025
www.nature.com/articles/s41... In collaboration with Andrew Lang and Alison Buchan, we just published a review on the complex and sometimes convoluted interactions and evolutionary relationships among bacterial mobile genetic elements. #phage #plasmid #evolution #bacteria #plasmidbiology #MGE
nature.com
Interactions and evolutionary relationships among bacterial mobile genetic elements - Nature Reviews Microbiology
In this Review, Lang and colleagues present an overview of the current knowledge landscape regarding mobile genetic elements in bacteria, with a focus on their evolutionary relationships and interacti...
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Aaron Vogan @fungage-lab.bsky.social · 07/03/2025
We did it! We caught Starship #transposons moving between #fungal species in the lab, including between species separated by ~100my. We think Starships are a mediator of HGT in fungi, akin to conjugative elements in bacteria. Check out the preprint. www.biorxiv.org/content/10.1...
Illustration depicting the ways in which fungi can exchange genetic material with each other. Starship mediated HGT is confirmed experimentally in this preprint.
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Department of Genetics, University of Cambridge @geneticscam.bsky.social · 07/03/2025
Why do some animals, like whales, live exceptionally long lives free from many age-related diseases? 🐋 Join Dr Alex Cagan to find out how nature’s solutions to longevity may hold the key to tackling our own health challenges. 🗓️ 03 April ⌚ 8-9pm 📍 Cambridge Union 🎫 Booking required
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George Ghanim @automnenine.bsky.social · 07/03/2025
Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch
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Sven Klumpe @svenklumpe.bsky.social · 05/03/2025
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
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Andrea Guarracino @andreaguarracino.bsky.social · 24/02/2025
Want to level up in #pangenomics? Join our workshop, conference & biohackathon in #Memphis, May 11-15, 2025. Connect with leading scientists, embrace genomic diversity, and contribute to cutting-edge software. Register now! pangenome.github.io/MemPanG25/ #Bioinformatics #MemPanG25
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Joana Meier @joanameier.bsky.social · 24/02/2025
Do you use Darwin Tree of Life (DToL) genomes for your work or grant applications? If so, can you please fill out this form? docs.google.com/forms/d/e/1F... We are gathering info on how DToL genomes are used. It will help us raise money to continue producing publicly available high-quality genomes.
docs.google.com
Darwin Tree of Life Impact Assessment
This form is used to share information within DToL about case studies, ongoing research, and funding awards that demonstrate the impact the Darwin Tree of Life consortium project has had on Global and...
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Cambridge Festival @cambridgefestival.bsky.social · 20/02/2025
Why do some animals, like whales, live exceptionally long lives free from many age-related diseases? 🐋 Join @atjcagan.bsky.social to see how nature’s solutions to longevity may hold the key to tackling our own health challenges: www.festival.cam.ac.uk/events/impos...
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Maddy Seale @maddyseale.bsky.social · 07/02/2025
(2/2) Giant sex chromosomes were discovered in Silene latifolia more than 100 years ago. Two papers back to back now show the sequence of the 550 Mbp Silene Y chromosome helping to understand sex determination www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... #plantscience
science.org
Rapid and dynamic evolution of a giant Y chromosome in Silene latifolia
Some plants have massive sex-linked regions. To test hypotheses about their evolution, we sequenced the genome of Silene latifolia, in which giant heteromorphic sex chromosomes were first discovered i...
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Berta Verd @bertaverd.bsky.social · 05/02/2025
I am recruiting an #ERC funded PostDoc to work on the evolution of vertebral counts in cichlids. This is an experimental project & will be looking for candidates with experience generating reporter lines, live-imaging and experimental embryology. Application deadline: 25th Feb. tinyurl.com/33jbu8fa
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Centre de Regulació Genòmica (CRG) @crg.eu · 11/02/2025
💜Feliz #11F y #DíadelaMujeryNiñaEnLaCiencia💜
lavanguardia.com
El 8-M de las científicas: miles de mujeres se vuelcan para despertar vocaciones en la niñas
Un movimiento imparable ha arrancado con fuerza: es el sigiloso 8-M de las científicas. Mujeres determinadas a enseñar a las chicas que pueden ser profesionales capaces
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Department of Genetics, University of Cambridge @geneticscam.bsky.social · 04/02/2025
This week from the Genetics Seminar Series: 👤 @justinmcrocker.bsky.social from @embl.org 🎤Drosophila in context: evolution, toxins, and behaviour 🗓️ Thursday 06 February 🕑 2 - 3pm 📍Biffen Lecture Theatre, Downing Site
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Pío Sierra @piosierra.bsky.social · 04/02/2025
⬇️⬇️⬇️ "Our study of three human neocentromeres and a native, repetitive human centromere reveal that CENP-A position and patterns of DNA methylation and H3K9me3 are heterogenous at the same centromere within a population of cells , and these epigenetically distinct centromeres are equally functional."
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José Cerca @naturalselection.bsky.social · 03/02/2025
New paper out 📝✨ "k-mer approaches for biodiversity genomics" We discuss k-mer spectra, sex determination, allopolyploid subgenome separation, among other topics - and offer a large tutorial list Link to paper: genome.cshlp.org/content/earl... Link to all tutorials: github.com/KamilSJaron/...
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Pío Sierra @piosierra.bsky.social · 03/02/2025
"Both the large-scale genomic and the micro-scale regulatory variations identified in this study highlight the importance of extensive and differential TE proliferation." www.nature.com/articles/s41...
nature.com
Transposon proliferation drives genome architecture and regulatory evolution in wild and domesticated peppers - Nature Plants
This study presents 11 telomere-to-telomere genomes of wild and domesticated pepper, highlights how transposable elements have shaped the evolution of genome structure and regulatory elements and iden...
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Pío Sierra @piosierra.bsky.social · 27/01/2025
This is interesting. "These results are consistent with the idea that most large events of gene acquisition are of MGEs encoding their own integrases."
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Matthew Cobb @matthewcobb.bsky.social · 26/01/2025
Putting the final touches to my Crick biography, it will go off for copy-editing at the end of this week. Over three years in someone else's head is enough. It will be out in October/November this year. 150k of text, 40k of notes. It will be a wrist-sprainer, but will look lovely I promise.
Screenshot that reads: 
CRICK:
A MIND IN MOTION, 
FROM DNA TO THE BRAIN
Matthew Cobb
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bioRxivpreprint @biorxivpreprint.bsky.social · 25/01/2025
Transposable Elements are Dysregulated in Brains of Individuals with Major Depressive Disorder www.biorxiv.org/content/10.1101/202…
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Paul Rowley @drpaulrowley.bsky.social · 22/01/2025
pubmed.ncbi.nlm.nih.gov/39786570/ Nice work showing how Ty retrotransposons have shaped Saccharomyces genus genomes.
pubmed.ncbi.nlm.nih.gov
Horizontal Transfer and Recombination Fuel Ty4 Retrotransposon Evolution in Saccharomyces - PubMed
Horizontal transposon transfer (HTT) plays an important role in the evolution of eukaryotic genomes; however, the detailed evolutionary history and impact of most HTT events remain to be elucidated. T...
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Pío Sierra @piosierra.bsky.social · 21/01/2025
A great work that benefits from a comparative genomics approach and highlights the difficulties of mapping TEs. www.cell.com/cell/fulltex...
cell.com
An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development
Mapping transcription start sites across five mammalian species before, during, and after embryonic genome activation unveils widespread transposable element-driven transcription and co-option of evol...
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ASAP Team Jakobsson @jakobssonasap.bsky.social · 18/01/2025
🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development. This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab. www.biorxiv.org/content/10.1...
biorxiv.org
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...
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Juan Díaz-Colunga @jdiazc9.bsky.social · 17/01/2025
⚠️ Job(s) alert! ⚠️ We are launching a new postdoctoral program in Systems Biology at IBFG. Join us! 👉 Several positions available with competitive work conditions for up to 4 years 📄 More info: jdiazc9.github.io/files/jobs/2...
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Pío Sierra @piosierra.bsky.social · 17/01/2025
"Centromere evolution is in fact the result of an interplay of various factors, including drift and selection during both mitosis and meiosis, following evolutionary trajectories that are constrained by the kinetochore interface."
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Pío Sierra @piosierra.bsky.social · 17/01/2025
TEs at work. Very interesting results.
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