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Chris Chatham

@chchatham.bsky.social
548 followers 764 following 78 posts

Designing experiments to sort the universe of possible medicines for the mind.

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Reposted by Chris Chatham
Evan Gordon @gordonneuro.bsky.social · 22/04/2026
I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...
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jonny (leachate composite form) @jo.nny.rip · 29/11/2025
One of the main things neuroscientists do not like to deal with is degeneracy and the irreversibility of the activity -> function relationship, because that would force them to acknowledge that most analysis methods like decoding and functional connectivity are meaningless.
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Natalie Christie Peluso 🧠 @nataliepeluso.com · 27/11/2025
🧠👀 'These findings reveal high-dimensional aspects of cortical representation undetectable with conventional methods, such as RSA, & contradict previous theories suggesting that high-level visual cortex representations are low-dimensional.' #neuroskyence journals.plos.org/ploscompbiol...
journals.plos.org
Universal scale-free representations in human visual cortex
Author summary The human cerebral cortex is thought to encode sensory information in population activity patterns, but the statistical structure of these population codes has yet to be characterized. ...
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Pierre Vanderhaeghen @vanderhaeghenp2.bsky.social · 27/11/2025
Please check out and RT this new position for an exciting collaborative project with @boninlab.bsky.social and @franckp.bsky.social on the links between human-specific mechanisms and neurodevelopmental disorders in cortical circuits.
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Chris Chatham @chchatham.bsky.social · 17/11/2025
A structurally profound update to the most comprehensive closed-form model of working memory & RL-like interactions. Really excited to see this evolution - and to learn if this new model might tell us something different about experimental drugs tested with the older task+model. Congrats Anne
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Chris Chatham @chchatham.bsky.social · 15/10/2025
Very proud to have played a part in this work. I am confident that measurements of speech contain signal of use for developing new therapeutics, transdiagnostically...
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Adam Kucharski @adamjkucharski.bsky.social · 01/09/2025
Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):
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Nick Myers @nick-myers.bsky.social · 26/08/2025
New paper using M/EEG to look at attractive and repulsive serial dependence in working memory, led by the excellent Jiangang Shan, with Jasper Hajonides.
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Arif A. Hamid, Ph.D. @arifahamid.bsky.social · 23/08/2025
Proud of Amy and Nick, who review technical and theoretical gaps in timescales of dopamine fluctuations. We argue that DA fluctuations are hierarchical control signals, and “tonic” DA relays goal alignment across planning horizons and C-BG hierarchy. www.sciencedirect.com/science/arti...
sciencedirect.com
Timescales of dopamine release in the striatum as a window into hierarchical control
The reinforcement learning community has made significant progress in understanding dopamine (DA) in reward learning, cognitive control, and motivatio…
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Chris Chatham @chchatham.bsky.social · 21/08/2025
This is an encouraging result for the use of EEG in a variety of applications going well beyond RSA.
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Reposted by Chris Chatham
Simon W Davis @woodforbrains.bsky.social · 21/08/2025
EEG representational analyses are more robust than fMRI. Huh. link.springer.com/article/10.1...
link.springer.com
How Robust Are fMRI- and EEG-Based Representational Similarity Analysis? - Computational Brain & Behavior
In EEG and fMRI analysis, researchers choose from a combinatorially large set of theoretically indistinguishable options while building a data processing pipeline based on individual beliefs and other...
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Tom Donoghue @tomdonoghue.bsky.social · 21/08/2025
I've updated my literature review of studies of aperiodic neural activity in clinical disorders, adding ~30 papers, taking it to 177 reports across 38 disorders! It's got a review of results so far, discussion of themes & issues, & recommendations for future work! www.medrxiv.org/content/10.1...
medrxiv.org
A systematic review of aperiodic neural activity in clinical investigations
Aperiodic neural activity - activity with no characteristic frequency - has increasingly become a common feature of study, including in clinical work. Reports investigating aperiodic activity from pat...
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Reposted by Chris Chatham
Donner Lab @donnerlab.bsky.social · 27/06/2025
1/ New paper by Hame Park, (@AraziAyelet), Bharath Talluri, Marco Celotto, Stefano Panzeri, Alan Stocker & Tobias Donner published in Nature Communications – “Confirmation Bias through Selective Readout of Information Encoded in Human Parietal Cortex”: rdcu.be/etlR7. Here is a summary:
rdcu.be
Confirmation bias through selective readout of information encoded in human parietal cortex
Nature Communications - People often discard incoming information when it contradicts their pre-existing beliefs about the world. Here, the authors show that this discarded information is precisely...
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Chris Chatham @chchatham.bsky.social · 02/04/2025
Super talented team working on an incredibly important problem. Congrats!
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Chris Chatham @chchatham.bsky.social · 25/03/2025
Denali describing their approach to shuttle large molecules as cargo across the blood brain barrier. We should see new clinical data from approaches like this already in 2025. Exciting time for neurotherapeutics for this and so many other reasons...
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 25/03/2025
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules www.biorxiv.org/content/10.1101/202…
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 25/03/2025
Intellectual ability and cortical homotopy development in children and adolescents www.biorxiv.org/content/10.1101/202…
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Darren Dahly @statsepi.bsky.social · 24/03/2025
Here is the video I made, inspired by this wonderful tweet. www.youtube.com/watch?v=dSOj...
youtube.com
Why we randomize
YouTube video by Darren Dahly
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Chris Chatham @chchatham.bsky.social · 26/02/2025
How did these authors, reviewers and editors all entirely fail to note the fascinating discrepancy beween this finding and the protective effect of lithium for AD? bmcmedicine.biomedcentral.com/articles/10.... There's such an interesting discussion to be had on that! (1/n)
bmcmedicine.biomedcentral.com
Antidepressant use and cognitive decline in patients with dementia: a national cohort study - BMC Medicine
Background Dementia is associated with psychiatric symptoms but the effects of antidepressants on cognitive function in dementia are understudied. We aimed to investigate the association between antid...
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Chris Chatham @chchatham.bsky.social · 20/02/2025
Incredibly talented group and super important work from these teams at Boston Children's - great training opportunity for new PhDs thinking about a postdoc.
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Rich Law @drrichjlaw.bsky.social · 19/02/2025
As @dereklowe.bsky.social was asking, we need more pharma CEOs to speak up! Merck, Pfizer, Lilly, Amgen - where are your voices?! (BTW- really read to the bottom of this).
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Caitlin S., PhD @paleophile.bsky.social · 19/02/2025
The Democrats on the House Science Committee have set up a website to collect stories from fired federal employees, anonymously if desired. Please amplify. (This helps the lawyers establish standing for bringing legal cases against the administration!) democrats-science.house.gov/sciencefirings
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John Felt @jfeltphd.bsky.social · 19/02/2025
Will shadish had a great paper on this where participants were randomized to choose their condition or to be randomly assigned to condition www.statpower.net/Content/MLRM...
statpower.net
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Julia M. Rohrer @dingdingpeng.the100.ci · 18/02/2025
New guest post! Excluding "careless" responses is a routine practice in many contexts. But if careless responding itself is an outcome of the variables of interest, that may actually cause trouble.
In this scenario, we are interested in the effect of X on Y. However, careless responding is affected by Y. If we exclude respondents who show signs of careless responding -- and thus condition on this node -- we potentially bias our estimate of the effect of X on Y.
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Alejandro de la Vega @neurozorro.bsky.social · 14/02/2025
@briannosek.bsky.social I'm not sure if you're aware but your work on the reproducibility crisis is being cited by the Heritage Foundation to motivate the huge cuts to indirect costs we are seeing at NIH. How do you respond to this? www.heritage.org/sites/defaul...
heritage.org
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Phil Corlett @philcorlett.bsky.social · 13/02/2025
New preprint: elaborating the domain-general prediction error driven account of paranoia and delusion contents: osf.io/preprints/ps... Awesome to work with @praveensuthaharan.bsky.social Rosa Rossi-Goldthorpe, @juliasheffield.bsky.social, Santiago Castiello, and @celiaheyes.bsky.social on this
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Chris Chatham @chchatham.bsky.social · 13/02/2025
More killer stuff from the Roche EEG team. Wow
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Xiaosi Gu @xiaosigu.bsky.social · 07/02/2025
Super excited to share this paper that just came out today in@naturementalhealth.bsky.social led by @sarahbanker.bsky.social, where we show important phenotypic divergence between online subjects who self reported high autism traits and those formally diagnosed by clinicians.
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Krish D. Singh @magnetokrishio.bsky.social · 06/02/2025
We are very excited to announce the open release of a new 170 participant dataset: Linked MEG, TMS, multimodal 3T MRI, 7T MRI, Connectom MRI, cognitive /questionnaire data. Immense effort from a fabulous CUBRIC team. Paper by Carolyn McNabb et al: doi.org/10.1038/s415...
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Kelly Donegan @kellydonegan.bsky.social · 24/10/2024
Null findings are important ‼️ Excited to share my latest work finding model-based planning does NOT improve following ketamine 💉, antidepressant 💊, or iCBT 👩‍💻 treatments 🧵👇🏻
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Isaac Fradkin @fradkinisaac.bsky.social · 25/11/2024
I’m excited to share our new, open-access paper published today in NatMentHealth, “Latent mechanisms of language disorganization relate to specific dimensions of psychopathology”. www.nature.com/articles/s44...
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Micah G. Allen @micahgallen.com · 26/11/2024
Great new work on the link between thoughts and psychological traits! #neuroskyence #psychscisky
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Peter Kok @peterkok.bsky.social · 22/11/2024
Interesting study on the computational role of prior probability in perceptual choices, finding that priors change the accumulation rate of evidence rather than the baseline. Nicely in line with work by @clarepress.bsky.social & @danieljamesyon.bsky.social: pmc.ncbi.nlm.nih.gov/articles/PMC... 🧠🤖 🧠🟦
pmc.ncbi.nlm.nih.gov
Action Biases Perceptual Decisions Toward Expected Outcomes
We predict how our actions will influence the world around us. Prevailing models in the action control literature propose that we use these predictions to suppress or “cancel” perception of expected a...
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David_Pascucci @davidpascucci.bsky.social · 23/11/2024
Entrainment explains fascinating phenomena like fireflies flashing in sync—but can the brain be 'entrained' by rhythmic stimuli? With @maelanmenetrey.bsky.social, we tested key features of neural entrainment, suggesting specialized tuning mechanisms. #EEG #neuroskyence doi.org/10.1186/s129...
doi.org
Spectral tuning and after-effects in neural entrainment - Behavioral and Brain Functions
Neural entrainment has become a popular technique to non-invasively manipulate brain rhythms via external, periodic stimulation. However, there is still debate regarding its underlying mechanisms and ...
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Reposted by Chris Chatham
Manlio De Domenico @manlius.bsky.social · 22/11/2024
An update on this #scaling matter, for the curious ones. The connectivity from 256k users still confirms the non-power-law shape of the (observed) network (left). Over time, the mean connectivity decreases (right), but more robust analysis is needed to understand biases & mechanisms. 1/
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Chris Chatham @chchatham.bsky.social · 23/11/2024
Wish I was attending psychonomics to see this. Intraindividual variation is such an exciting, potentially important, and too often neglected dimension of individual differences.
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Theresa Desrochers, Ph.D. @desrocherslab.bsky.social · 21/11/2024
New findings: We track visual sequences yet the brain's process is unclear. We discovered the sequence-tracking area in monkey's lateral prefrontal cortex is distinct from an adjacent subregion that reacts to other stimulus changes. #neuroscience 🧠 🧪 👩‍🔬
buff.ly
Different Subregions of Monkey Lateral Prefrontal Cortex Respond to Abstract Sequences and Their Components
Sequential information permeates daily activities, such as when watching for the correct series of buildings to determine when to get off the bus or train. These sequences include periodicity (the…
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Chris Chatham @chchatham.bsky.social · 23/11/2024
One of the challenges I saw with federated learning was that there’s not much incentive for each individual node to undertake the administrative burden of joining the network. One interesting incentive that I haven’t seen acknowledged is that the individual nodes are in a privileged position to see…
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Zack Williams, MD, PhD @quantpsychiatry.bsky.social · 20/11/2024
For all my friends who just got here to BlueSky and want some cool people to follow, I've now delved into the wonderful world of Starter Packs (full list at blueskydirectory.com/starter-pack...). Here's a thread of some of the cool ones I found!
blueskydirectory.com
Bluesky Starter Packs - Bluesky Directory
Browse a list of Bluesky Starter Packs. Discover and connect with your community on Bluesky
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Chris Chatham @chchatham.bsky.social · 21/11/2024
NREM sleep improves behavioral performance by desynchronizing cortical circuits. Ed summary: "positive effects of sleep replicated by low-frequency intracortical electrical stim. Computational modeling suggested ... an asymmetric decrease in synaptic conductances" www.science.org/doi/10.1126/...
science.org
NREM sleep improves behavioral performance by desynchronizing cortical circuits
Sleep improves cognitive performance, yet little is known about the neural mechanisms of this improvement. We performed multielectrode recording in macaque visual and dorsolateral prefrontal cortex wh...
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 21/11/2024
Strikingly different neurotransmitter release strategies in dopaminergic subclasses www.biorxiv.org/content/10.1101/202…
biorxiv.org
Strikingly different neurotransmitter release strategies in dopaminergic subclasses https://www.biorxiv.org/content/10.1101/2024.11.20.622499v1
Neuronal function is intimately tied to axodendritic polarity. Neurotransmitter release, for example
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Chris Chatham @chchatham.bsky.social · 21/11/2024
Psychiatry has the most black box warnings of any area. Could the others backfire, too? Deep respect for the regulators responsible for these complex decisions. *Especially* now, better health vigilance systems are needed. Can’t wait 20y to discover the next counterintuitive effect of policy changes
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Kevin Mitchell @wiringthebrain.bsky.social · 21/11/2024
Common genetic variants contribute more to rare diseases than previously thought www.nature.com/articles/d41... (note that the converse is also true!!!)
nature.com
Common genetic variants contribute more to rare diseases than previously thought
Assessing the influence of common mutations on rare disease risk.
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mr. TIM @timkellogg.me · 12/11/2024
Scaling Laws for Precision yes, llama models are harder to quantize. They’re “overtrained”, on more data, so quantization removes a lot of critical information arxiv.org/abs/2411.04330
arxiv.org
Scaling Laws for Precision
Low precision training and inference affect both the quality and cost of language models, but current scaling laws do not account for this. In this work, we devise "precision-aware" scaling laws for b...
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Dan McNeish @dmcneish.bsky.social · 13/11/2024
This article gives a phenomenal overview of the history and evolution of best practices in measurement invariance and differential item functioning -- I can't remember the last time I learned so much reading a single paper, highly recommended! www.tandfonline.com/doi/full/10....
tandfonline.com
A Review of Some of the History of Factorial Invariance and Differential Item Functioning
The concept of factorial invariance has evolved since it originated in the 1930s as a criterion for the usefulness of the multiple factor model; it has become a form of analysis supporting the vali...
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Chris Chatham @chchatham.bsky.social · 28/10/2024
Amazing work. A total speculation: superior predictive validity of self-report vs task perf metrics (accuracy, RT, etc) may arise from analogous dissociations btwn the lower-dim probes of '1st-order' task performance metrics, vs higher-dim / '2nd-order' judgements ("How *DO* I feel [wrt X_1...N]?")
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 12/08/2024
AmygdalaGo-BOLT3D: A boundary learning transformer for tracing human amygdala www.biorxiv.org/content/10.1101/202…
biorxiv.org
AmygdalaGo-BOLT3D: A boundary learning transformer for tracing human amygdala https://www.biorxiv.org/content/10.1101/2024.08.11.607487v1
Automated amygdala segmentation is one of the most common tasks in human neuroscience research. Howe
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John Towse @jntowse.bsky.social · 12/08/2024
If I might interject … yes there’s a literature on some relevant factors in scams (eg overlap with reflective thinking) doi.org/10.4018/IJCB... doi.org/10.1371/jour... ucilnica.fri.uni-lj.si/pluginfile.p... And increasingly more recent work in this area (too much for one post!)
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Johns Hopkins Berman Institute of Bioethics @bermaninstitute.bsky.social · 07/08/2024
The UK launched a metascience unit. Will other countries follow suit? Tasked with finding better ways to conduct, distribute and fund research, the unit could set the standard for government-led ‘science of science’ initiatives. www.nature.com/articles/d41...
nature.com
The UK launched a metascience unit. Will other countries follow suit?
Tasked with finding better ways to conduct, distribute and fund research, the unit could set the standard for government-led ‘science of science’ initiatives. Tasked with finding better ways to conduc...
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Chris Chatham @chchatham.bsky.social · 09/08/2024
Has anyone got a large (>=7b) GPT running on a neuromorphic chip? Who’s working on this & how close is this? Inference time scaling laws have me suddenly fascinated by physical computing hardware & where it’s gone since I last tracked that area (longer ago than I care to admit).
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