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Rich Law

@drrichjlaw.bsky.social
937 followers 163 following 244 posts

Chief Business Officer of Haya Therapeutics! (formerly Exscientia/Recursion CBO), computational chemist by training (Oxford, UCSD, LLNL & Evotec), bike racer, ex-Oxford rower & LFC fan! #YNWA.

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Rich Law @drrichjlaw.bsky.social · 25/06/2025
NHS & NICE double down on their decision to not approve Eli Lilly’s donanemab and Biogen/Eisai’s lecanemab due to lack of cost effectieve efficacy; www.ddw-online.com/nice-rejects...
ddw-online.com
NICE rejects Alzheimer’s drugs for lack of cost-effectiveness - Drug Discovery World (DDW)
The UK National Institute for Health and Care Excellence (NICE) has reached its final decision on two Alzheimer’s treatments, denying their use on the NHS due to the therapies not providing “good valu...
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Rich Law @drrichjlaw.bsky.social · 12/06/2025
BioNTech to acquire CureVac $CVAC in all-stock deal valued at $1.25B (although they have $500M in cash!) - 30% premium on close but only ~10% of it's MC from 4 yrs ago. endpoints.news/biontech-to-...
endpoints.news
BioNTech to acquire CureVac in all-stock deal valued at $1.25B
BioNTech plans to buy mRNA-based cancer immunotherapy and infectious disease vaccine company CureVac in an all-stock deal, the companies said Thursday.
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Rich Law @drrichjlaw.bsky.social · 12/06/2025
BioNTech to acquire CureVac $CVAC in all-stock deal valued at $1.25B (although they have $500M in cash!) - 30% premium on close but only ~10% of it's MC from 4 yrs ago. endpoints.news/biontech-to-...
endpoints.news
BioNTech to acquire CureVac in all-stock deal valued at $1.25B
BioNTech plans to buy mRNA-based cancer immunotherapy and infectious disease vaccine company CureVac in an all-stock deal, the companies said Thursday.
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Rich Law @drrichjlaw.bsky.social · 12/06/2025
Schrödinger says early MALT1 data could lay 'great foundation' for combos. Indeed the future of oncology is very much about combination therapies & in many complex biological settings, we need to get over the need for single agent efficacy for everything. endpoints.news/eha25-schrod...
endpoints.news
Schrödinger says early MALT1 data could lay 'great foundation' for combos
Schrödinger said its experimental MALT1 inhibitor showed early signs of safety and efficacy in an ongoing Phase 1 trial.
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Rich Law @drrichjlaw.bsky.social · 11/06/2025
Sofinnova Partners Collaborates With NVIDIA to Accelerate European Life Sciences Startups www.businesswire.com/news/home/20...
businesswire.com
Sofinnova Partners Collaborates With NVIDIA to Accelerate European Life Sciences Startups
Sofinnova Partners (“Sofinnova"), a leading European life sciences venture capital firm based in Paris, London, and Milan, today announced a collaboration wi...
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Rich Law @drrichjlaw.bsky.social · 02/06/2025
Sanofi to buy Blueprint Medicines in deal worth more than $9 billion (roughly 30% premium on Friday close). $BPMC $XBI www.statnews.com/2025/06/02/s...
statnews.com
Sanofi to buy Blueprint Medicines in deal worth more than $9 billion
Sanofi plans to buy Blueprint Medicines in a deal worth more than $9 billion, expanding its immunology pipeline
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Rich Law @drrichjlaw.bsky.social · 02/06/2025
Bristol Myers $BMY bets $1.5B on BioNTech's PD-L1xVEGF from Chinese Biotheus partner. endpts.com/bristol-myer...
endpts.com
Bristol Myers bets $1.5B on BioNTech's PD-L1xVEGF from Biotheus
BioNTech bought out its China-based biotech partner Biotheus for $800 million upfront in November. Now, the German drugmaker is set to receive $1.5 billion upfront from Bristol Myers Squibb to co-deve...
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Reposted by Rich Law
Ruben Sebastian @rubensebas.bsky.social · 02/06/2025
Sanofi to acquire Blueprint Medicines $BPMC for $9.1 billion #immunology #deal #pharma #biotech www.sanofi.com/en/media-roo...
sanofi.com
Press Release: Sanofi to acquire Blueprint Medicines, expanding portfolio in rare immunological disease and adding early-stage pipeline in immunology
Sanofi to acquire Blueprint Medicines, expanding portfolio in rare immunological disease and adding early-stage pipeline in immunology Adds fast-growing and only approved medicine for advanced and...
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Rich Law @drrichjlaw.bsky.social · 31/05/2025
Detailed doc released showing how NIH’s discretionary budget will be slashed to $27.5 billion, an $18 billion or nearly 40% reduction. It also details plans to consolidate the agency’s 27 institutes & centers into just 8. www.statnews.com/2025/05/30/n...
statnews.com
New HHS document details deep NIH cuts as part of Trump budget request
Budget documents for Congress provide the most detailed look yet at how the Trump Administration hopes to reshape the National Institutes of Health.
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Rich Law @drrichjlaw.bsky.social · 30/05/2025
"About a quarter of the approximately 13,600 drug-target pairs in the current preclinical and clinical R&D pipeline are concentrated around just 38 unique biological targets." - LEK. This is astonishing & a huge misappropriation of risk by investors. www.lek.com/insights/hea...
lek.com
Is Biopharma Doing Enough to Advance Novel Targets? | L.E.K. Consulting
Is Biopharma Doing Enough to Advance Novel Targets?
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Rich Law @drrichjlaw.bsky.social · 29/05/2025
Great interview (read) with @HAYA_lncRNA CEO SAmir Ounzain as he talks about the unique science of Haya & executing as a first-in-biology biotech. pharmaboardroom.com/interviews/s...
pharmaboardroom.com
Samir Ounzain – CEO & Scientific Co-Founder, HAYA Therapeutics
What if the key to treating chronic and age-related diseases has been hidden in plain sight, within…
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Rich Law @drrichjlaw.bsky.social · 27/05/2025
Investors pump $130M into protein degrader startup GlycoEra endpts.com/investors-pu...
endpts.com
Investors pump $130M into protein degrader startup GlycoEra
Protein degrader shop GlycoEra, spun out of vaccines company LimmaTech in 2021, has corralled $130 million in Series B funding to get into the clinic. The transatlantic outfit's experimental medicines...
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Rich Law @drrichjlaw.bsky.social · 23/05/2025
Merus’ $MRUS Phase 2 overall survival data reach ‘home run’ scenario with their EGFR/LGR5 bispecific petosemtamab. endpts.com/asco25-merus...
endpts.com
Merus’ Phase 2 overall survival data reach ‘home run’ scenario — analyst
Merus completed its rollout of Phase 2 head and neck cancer data on Thursday, touting overall survival results that at least one analyst said amount to a best-case outcome. ...
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Rich Law @drrichjlaw.bsky.social · 21/05/2025
Altos Labs buys anti-aging startup Dorian Therapeutics for their "senoblockers". endpts.com/altos-labs-b...
endpts.com
Altos Labs buys anti-aging startup Dorian Therapeutics
Altos, led by industry stalwarts Hal Barron and Hans Bishop, brought Dorian Therapeutics into its fold this week, according to LinkedIn posts from the nimble company's co-founders.
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Rich Law @drrichjlaw.bsky.social · 21/05/2025
Orionis Biosciences (private) Announces Strategic Partnership with Genentech to Discover and Develop Molecular Glue Class Medicines for Cancer - $105M upfront, $2bn potential. orionisbio.com/2025/05/gene...
orionisbio.com
Orionis Biosciences Announces Strategic Partnership with Genentech to Discover and DevelopMolecular Glue Class Medicines for Cancer - Orionis Biosciences
Orionis Biosciences has announced a second collaboration with Genentech, worth $105 million upfront and up to $2 billion in potential milestone payments, to develop small-molecule glue medicines for o...
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Rich Law @drrichjlaw.bsky.social · 07/05/2025
It'll be great to see everyone in Bruges and discuss some of the amazing progress that Haya Therapeutics is making in the pipeline and platform for finding, validating & drugging chronic disease state reversing targets in the regulatory genome! #BioEquity🧬 ❤️ 🫁 🦀
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Rich Law @drrichjlaw.bsky.social · 30/04/2025
Octagon shuts down after R&D challenges. Will be a trend in biotech in 2025. www.fiercebiotech.com/biotech/octa...
fiercebiotech.com
Octagon shuts down after R&D challenges put it behind the 8 ball
Octagon Therapeutics has thrown in the towel. | Octagon Therapeutics has thrown in the towel. The Novo Nordisk-allied autoimmune disease biotech is winding down after deprioritizing its lead program a...
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Rich Law @drrichjlaw.bsky.social · 30/04/2025
While on the subject of crowding (a talk given by AZ!), AstraZeneca Abandons Neuroscience, Prioritizes Weight Loss, Immunology. $XBI www.biospace.com/business/ast...
biospace.com
AstraZeneca Abandons Neuroscience, Prioritizes Weight Loss, Immunology
Following the recent discontinuations of assets in Alzheimer’s and migraine, AstraZeneca is stepping away from neuro altogether.
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Rich Law @drrichjlaw.bsky.social · 30/04/2025
Congrats to Haya Therapeutics CEO Samir Ounzain on being recognized as a top innovator on the Medicine Makers Power List. Just getting started! @HAYA_lncRNA themedicinemaker.com/awards/the-p...
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Rich Law @drrichjlaw.bsky.social · 30/04/2025
There is massive growth of "crowding" around the same targets in drug R&D over the last 20 years, with huge competition for every pharma/biotech & reduction in cost of entry via Chinese molecules. Novel targets are becoming everything for biotech to compete! $XBI (Aradhana - AZ)
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Rich Law @drrichjlaw.bsky.social · 30/04/2025
Eli Lilly pens Creyon Bio AI oligonucleotide pact with $1B in biobucks on the table www.fiercebiotech.com/biotech/eli-...
fiercebiotech.com
Eli Lilly pens Creyon Bio AI oligonucleotide pact with $1B in biobucks on the table
Eli Lilly is paying $13 million upfront, with $1 billion in biobucks up for grabs, for the opportunity to develop AI-designed oligonucleotide therapies from Creyon Bio.  | Eli Lilly is paying $13 mill...
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Rich Law @drrichjlaw.bsky.social · 25/04/2025
Caribou lays off 32% of staff & cuts lupus cell therapy program. “It is simply a reflection that we live in a moment where we have to do a small number of things incredibly well” - CEO Rachel Haurwitz. Good honesty in the toughest ever time for biotech. endpts.com/caribou-lays...
endpts.com
Caribou lays off 32% of staff, cuts lupus cell therapy program before first patient
Caribou Biosciences is paring down its pipeline and cutting about a third of its workforce as cell and gene therapy companies continue to struggle amid a bleak biotech market.
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Reposted by Rich Law
Scott Gottlieb, MD @scottgottliebmd.bsky.social · 25/04/2025
Steve Usdin writing in BioCentury: “It’s official: FDA says its cuts are delaying drug regulation — Layoffs, lack of access to journals slow response FDA says”
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Rich Law @drrichjlaw.bsky.social · 25/04/2025
Haya Therapeutics www.nature.com/articles/d43...
nature.com
Reprogramming the software of the cell to fight disease
HAYA Therapeutics is using its unparalleled regulatory genome atlas and innovative proprietary platform to identify novel long non-coding RNAs and develop drug candidates that return diseased cells ba...
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Reposted by Rich Law
Drew Harwell @drewharwell.com · 24/04/2025
New: We analyzed Trump's meme coin - At least 27 crypto wallets have picked up $100 million worth of $TRUMP coins since his team said the top holders would join him for an "intimate private dinner." Huge profit for Trump; "the most brazenly corrupt thing a President has ever done" wapo.st/4iAatO1
washingtonpost.com
How Trump team turned a dinner invite into a crypto boon worth millions
iNearly two dozen crypto wallets acquired more than 100,000 $TRUMP meme coins, worth roughly $100 million, after the team said top buyers could join the president for dinner.
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Reposted by Rich Law
Brian Naughton @btnaughton.bsky.social · 24/04/2025
There are now a trio of great pieces covering the rapid rise of Chinese biotech: - atelfo.github.io/2024/12/20/w... - centuryofbio.com/p/commoditiz... - www.asimov.press/p/china-trials
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Reposted by Rich Law
Isabella Cueto @isabellacueto.bsky.social · 24/04/2025
Who can even remember everything that's happened in the world of health, medicine and science since President Trump took office again ~100 days ago? @usha.bsky.social made this comprehensive timeline, with links to all of STAT's reporting since day 1: www.statnews.com/2025/04/24/t...
statnews.com
Day by day, how Trump is roiling science and health
STAT is tracking, day by day, what's happened in the words of science and health during the first months of the Trump administration.
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Reposted by Rich Law
Derek Lowe @dereklowe.bsky.social · 21/04/2025
Thoughts on Demis Hassabis of Google DeepMind saying that AI could cure disease in general in ten years. Bonus index to my longer posts on AI/computational drug discovery over nearly 20 years!
science.org
The End of Disease
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Reposted by Rich Law
mariewalsh18.bsky.social @mariewalsh18.bsky.social · 22/04/2025
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Reposted by Rich Law
Richard Van Noorden @richvn.bsky.social · 22/04/2025
Evidence of US brain drain? US scientists submitted 32% more applications for jobs abroad Jan-Mar 2025 than during same period in 2024. US-based users browsing jobs abroad increased by 35%. Data from Nature Careers global science jobs platform. www.nature.com/articles/d41...
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Rich Law @drrichjlaw.bsky.social · 24/04/2025
Bristol Myers CEO signals dealmaking will be a top priority in 2025 $BMY endpts.com/bristol-myer...
endpts.com
Bristol Myers CEO signals dealmaking will be a top priority in 2025
During Thursday’s first-quarter earnings call, Chris Boerner made his strongest comments yet that Bristol Myers intends to be active at the dealmaking table this year.
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Rich Law @drrichjlaw.bsky.social · 24/04/2025
A rare lesser spotted biotech series A has been sighted; Chicago startup Grove Biopharma nabs $30M (originally $50M) to go after making biologics that can hit intracellular targets. endpts.com/exclusive-ch...
endpts.com
Exclusive: Chicago startup Grove Biopharma nabs $30M Series A
A small Northwestern University spinout attempting to develop a twist on biologics has pulled together a $30 million Series A. The startup, named Grove Biopharma, weathered the pandemic and, after ...
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Reposted by Rich Law
Eric Topol @erictopol.bsky.social · 20/04/2025
The surprising result for a GLP-1 pill (orforglipron) is the magnitude of weight loss in a Phase 3 trial of participants with Type 2 diabetes. For still unexplained reasons, people with diabetes lose much less weight on GLP-1 drugs than those with obesity, w/o diabetes.
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Rich Law @drrichjlaw.bsky.social · 20/04/2025
Welcome to slop world: how the hostile internet is driving us crazy - on.ft.com/4cG93jt via @FT
on.ft.com
Welcome to slop world: how the hostile internet is driving us crazy
The last bits of fellowship and ingenuity on the web are being swept away by a tide of so-called artificial intelligence
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Rich Law @drrichjlaw.bsky.social · 18/04/2025
A biotech zombie killer! Alis Biosciences, a fund for struggling biotechs takes aim at ‘tragedy’ for shareholders - on.ft.com/4jfiqZU via @FT
on.ft.com
Fund for struggling biotechs takes aim at ‘tragedy’ for shareholders
Alis Biosciences then plans to list and offer big investors an easy way to spread their bets
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Reposted by Rich Law
Pam Herd @pamherd.bsky.social · 18/04/2025
DOGE is killing NIH. They froze the panels that determine funding. Then they froze funding announcements. Then they cancelled 100s of funded grants. Now they're freezing the remaining funded grants by making it impossible to actually access the funds www.washingtonpost.com/politics/202...
washingtonpost.com
DOGE begins to freeze health-care payments for extra review
DOGE is putting new curbs on billions of dollars in federal grants, requiring officials to manually review and approve payments that were previously routine.
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Reposted by Rich Law
BK. Titanji @boghuma.bsky.social · 16/04/2025
It's not just measles fam. Whooping cough a.k.a Pertussis have skyrocketed in the United States 1500% since 2021! Beloved, why do we insist on returning to medieval times when most children died in infancy with an abundance of effective vaccines? www.propublica.org/article/whoo...
propublica.org
“Not Just Measles”: Whooping Cough Cases Are Soaring as Vaccine Rates Decline
While much of the country is focused on the spiraling measles outbreak, experts warn that whooping cough and other preventable diseases could get much worse with falling vaccination rates and Trump’s ...
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Rich Law @drrichjlaw.bsky.social · 17/04/2025
Myself, Eric, & Samir, will be at the Swiss Biotech Days May 5-6th (2025), in Basel. Looking forward to sharing HAYA’s mission to advance disease-modifying medicines faster to patients by harnessing the regulatory genome to reprogram cells & reverse disease.🧬@HAYA_lncRNA
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Rich Law @drrichjlaw.bsky.social · 17/04/2025
BigHat inks Lilly deal for AI-boosted antibodies & extends Series B from $75M to $120M. Congrats & good luck to Peyton & the team! 👏 endpts.com/bighat-inks-...
endpts.com
Exclusive: BigHat inks Lilly deal for AI-boosted antibodies, extends Series B
BigHat Biosciences has added another pharma partner and more cash to its balance sheet as the antibody specialist prepares to enter the clinic next year. The Bay Area startup will ...
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Rich Law @drrichjlaw.bsky.social · 16/04/2025
47 first financings, inc pre-seed, seed & Series A, for biotech in US & Europe in Q1'25. Of the $2.6B, $1.9B (73%) went to just 6 companies, including a massive $600 million bet on Alphabet’s Isomorphic Labs. endpts.com/in-a-rocky-y...
endpts.com
Biotech seed rounds sink to lowest level in years as industry slump drags on
Port Therapeutics and other early biotech startups face funding challenges as investors prefer clinical-stage companies, with Q1 2025 seeing lowest startup funding in decade.
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Rich Law @drrichjlaw.bsky.social · 16/04/2025
Trump proposes to end the always stupid 4 yr disparity (9 or 13 yrs) between small & big molecules in IRA drug pricing negotiations. No-one is yet saying how or to what number! $XBI endpts.com/trump-pledge...
endpts.com
Trump pledges his support for a change to the IRA long sought by drugmakers
Trump signs EO on drug pricing, supports PhRMA reforms for Medicare negotiations timeline, calls for Canadian drug imports, and includes 340B program changes for EpiPens and insulin.
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Reposted by Rich Law
gamera obscura october edition @ohrobin.bsky.social · 08/04/2025
Here’s a real-time tracker of all (so far) confirmed campus abductions and visa revocations since April 2:
wearehighered.org
Campus Abductions — We Are Higher Ed
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Neil Lewis, Jr. @neillewisjr.bsky.social · 09/04/2025
Welp www.nytimes.com/2025/04/08/u...
nytimes.com
Trump Officials Freeze $1 Billion for Cornell and $790 Million for Northwestern
The funding pause amid civil rights investigations into both universities sharply escalates the Trump administration’s campaign against elite colleges.
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Rich Law @drrichjlaw.bsky.social · 08/04/2025
A "scrappy" (love that term!) team of drug developers at Merida Biosciences gets $121M to treat autoimmune and allergy diseases at their roots (@ky_lahucik ) endpts.com/exclusive-me...
endpts.com
Exclusive: Merida Biosciences gets $121M to treat autoimmune and allergy diseases at their roots
A scrappy team of drug developers has come together to create new medicines for patients with autoimmune diseases and allergies. They're going after the bustling subfield of Graves' disease and ...
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Reposted by Rich Law
Endpoints News @endpts.com · 08/04/2025
A $15B federal boost is needed to maintain the U.S. biotech edge, a new report warns, as proposed Trump-era research cuts threaten to cede ground to China’s fast-growing innovation engine.
endpts.com
Amid Trump’s research cuts, commission says US risks losing biotech race without $15B investment
A congressional commission is advocating for a $15 billion federal investment in America’s biotechnology sector, warning that the US could soon be eclipsed by China in a key frontier of ...
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Reposted by Rich Law
Eric Topol @erictopol.bsky.social · 08/04/2025
DOGE ended our wastewater surveillance program for San Diego County
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Rich Law @drrichjlaw.bsky.social · 08/04/2025
Tango Therapeutics has laid off about 30 employees and is now focusing on its PRMT5 programs; www.linkedin.com/posts/tango-...
linkedin.com
In light of the extremely challenging financial markets and our strong… | Tango Therapeutics
In light of the extremely challenging financial markets and our strong conviction in the value of our clinical programs, we, like so many others, have been forced to take steps to extend our cash runw...
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Rich Law @drrichjlaw.bsky.social · 07/04/2025
‘This is self-inflicted’: Leerink’s David Risinger on the market shock and hits to biopharma endpts.com/this-is-self...
endpts.com
‘This is self-inflicted’: Leerink’s David Risinger on the market shock and hits to biopharma
To make sense of the stock selloff that started late last week, Endpoints News’ Max Bayer and Drew Armstrong spoke to Leerink Partners senior managing director David Risinger, who has been working on ...
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Rich Law @drrichjlaw.bsky.social · 07/04/2025
I'll be at the @1STRAND_RNA event in San Diego tomorrow to meet people & listen to what promises to be a fascinating talk from Rudi Micheletti about how Haya Therapeutics @HAYA_lncRNA is unlocking chronic diseases like heart failure & obesity via the regulatory genome.
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Rich Law @drrichjlaw.bsky.social · 02/04/2025
63 biopharma did layoffs in Q1'25. 3.5 yrs into this "biotech winter" there are scant signs of a bottom yet (I think there were some but Trump/Musk/RFK has killed off the green shoots). www.fiercebiotech.com/biotech/biop...
fiercebiotech.com
Biopharmas laid off staffers at least 63 times in Q1: Fierce Biotech analysis
At least 63 biopharma layoff rounds were conducted in the first quarter of this year, with cell and gene biotechs accounting for nearly a third of those rounds. | At least 63 biopharma layoff rounds w...
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