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The Jackson Laboratory is inviting applications for Assistant and Associate Professors at our Mammalian Genetics campus in Bar Harbor, Maine.

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A study published by Public Health Scotland finds that the HPV vaccine is "highly effective".

Nature Reviews Molecular Cell Biology, Published online: 14 August 2026; doi:10.1038/s41580-026-01012-9Mitophagy contributes to cellular homeostasis through the recycling of damaged mitochondria and precise control of mitochondrial numbers. In this Review, Martens and Ganley summarize the molecular mechanisms involved in mitophagy pathways, mitophagy regulation and roles in disease.

Cytoplasmic lattices (CPLs) are filamentous assemblies essential for mammalian embryonic development. They are known to regulate organelle organization, spindle assembly, and protein homeostasis, but ...

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Autophagosome biogenesis requires delivery of millions of phospholipids. In budding yeast, Atg2 and Atg18 couple the ER to the isolation membrane for lipid transport, yet the mechanism is poorly under...

Clathrin-mediated endocytosis (CME) internalizes cell-surface receptors via clathrin-coated invaginations of the plasma membrane. Both clathrin and endocytic cargo are recruited to these sites by the ...

Autophagy degrades various intracellular components by sequestering them within membrane vesicles called autophagosomes and delivering them to lyso...

In cells, ESCRT-III is unique in mediating fission of membrane necks from inside, a process called reverse-topology fission. Yet, in vitro, the complex primarily assembles outside membrane necks and m...

Cells use multiple protein quality control (PQC) mechanisms to counteract the toxic effects of protein aggregation caused by cellular stress, ageing or disease. While it is known that PQC mechanisms d...

Singh et al. reveal that the lipid-handling autophagy proteins ATG9A and ATG2 regulate extracellular vesicle production by shaping cellular lipid composition and controlling whether cargo is degraded ...

Singh et al. reveal that the lipid-handling autophagy proteins ATG9A and ATG2 regulate extracellular vesicle production by shaping cellular lipid composition and controlling whether cargo is degraded ...

Mitochondria adapt their structure through fusion and fission. Here the authors couple array and cryo-electron tomography with proteomic analysis to descript changes in the mitochondrial network and c...