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Burcu Darst

@burcudarst.bsky.social
138 followers 155 following 11 posts

Genetic Epidemiologist, Assistant Professor, Fred Hutch Cancer Center

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Reposted by Burcu Darst
The American Journal of Human Genetics @ajhgnews.bsky.social · 05/02/2026
🧬New from @burcudarst.bsky.social & co 📄Validation and context-dependent effects of a prostate cancer polygenic risk score in the #AllofUs Research Program
cell.com
Validation and context-dependent effects of a prostate cancer polygenic risk score in the All of Us Research Program
This investigation demonstrates the validity and high predictive ability of a prostate cancer polygenic risk score (PRS) across populations in the All of Us Research Program. It further demonstrates t...
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SeaTea @tierno158.bsky.social · 10/11/2025
For #Readers: The Rory Gilmore Reading Challenge is pretty darn great. It has the 339 books (novels, nonfiction, plays, poetry) that Rory of the The Gilmore Girls* is shown reading. I'm only at 23% so I need to get to steppin'. * I've haven't seen an episode...yet. share.google/2IBopgRRRtpf...
share.google
The Rory Gilmore Reading Challenge
Over the course of seven seasons of Gilmore Girls, Rory Gilmore was seen reading 339 books on screen. How many have you read? From...
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Jeremy Berg @jeremymberg.bsky.social · 07/11/2025
8 high level positions at NIH posted including 6 institute director positions (NIMH, NIGMS, NICHD, NIDCR, NHGRI, NLM). Only open for 2 weeks (applications due November 21). Application materials include a) CV b) vision statement c) a photocopy of doctoral degree. hr.nih.gov/careers/open...
hr.nih.gov
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Dan Willingham @dtwuva.bsky.social · 17/10/2025
uva rejects the compact
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PRIMED Consortium @prsmethods.bsky.social · 14/10/2025
Attending #ASHG25? Learn how @prsmethods.bsky.social investigators are improving polygenic risk prediction in diverse populations by visiting these talks and posters docs.google.com/spreadsheets...
docs.google.com
ASHG 2025 PRIMED Abstracts
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Burcu Darst @burcudarst.bsky.social · 09/10/2025
Excited to share our recent work characterizing a type 2 diabetes (T2D) polygenic risk score (PRS) in a collaboration that included 244,637 T2D cases and 637,891 controls, led by @boyaguo.bsky.social! (1/3) www.nature.com/articles/s41...
nature.com
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations - Nature Communications
Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.
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Naguib Mechawar @naguibmechawar.bsky.social · 28/09/2025
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Iris Jia @tongqiu.bsky.social · 25/09/2025
Fred Hutch Girls Who Code is rolling again with another session on computational biology! Please share the word with high school students and educators 📅 Tuesdays 4:30-6pm, Oct 14 - Dec 2 📍 Fred Hutch (in-person) 🎯 Small groups, comp bio & fun Apply by Oct 10: form.jotform.com/fredhutch/fr...
form.jotform.com
Fred Hutch Girls Who Code Fall 2025 Application
Please click the link to complete this form.
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Javier Apfeld @javierapfeld.bsky.social · 25/09/2025
New cures feel sudden, but the seeds were planted decades ago by basic scientists. Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵
bbc.com
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
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Mike Inouye @mikeinouye.bsky.social · 19/09/2025
PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score... Our results were surprising... 👉 www.medrxiv.org/content/10.1...
medrxiv.org
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critica...
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sducrocq.bsky.social @sducrocq.bsky.social · 21/09/2025
Best of both worlds: You can pass a Linux command to data.table jozef.io/r917-fread-c...
jozef.io
How data.table's fread can save you a lot of time and memory, and take input from shell commands - Jozef's Rblog
In this post we write about experience with data.table's fread for reading tabular data from text files such as .csvs and how it compares to other packages like readr or base R.
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Ian Sudbery @iansudbery.bsky.social · 12/09/2025
This is now the third year that I'm reminded how greatful I am to @jkpritch.bsky.social when I'm preparing my human genetics lectures, for An Owner's Guide to the Human Genome (web.stanford.edu/group/pritch...). It really is the textbook we are all missing. Its crazy no real alternative exists.
web.stanford.edu
An Owner's Guide to the Human Genome
An Owner's Guide to the Human Genome
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Haky Im @hakyim.bsky.social · 12/09/2025
I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.
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Peter Kraft @peter-kraft.bsky.social · 08/09/2025
This was neat work by @nmancuso.bsky.social et al developing and benchmarking a new multi-ancestry fine-mapping method (“SuShiE”). I learned something about the performance of pooled v stratified analyses but still have some Qs. 1/n
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Gov. Bob Ferguson @governorferguson.bsky.social · 05/09/2025
Our Department of Health issued a Standing Order for the COVID-19 vaccine today, as we work to ensure that all Washingtonians 6 months or older have access to these vaccines. I will do everything in my power to protect our residents with policies still based in rigorous science.
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UCSC Genome Browser @genomebrowser.bsky.social · 05/09/2025
Please take a moment to tell us how you use the Genome Browser: surveymars.com/q/mnb... Your feedback supports future improvements and our continued funding.
surveymars.com
UCSC Genome Browser User Satisfaction Survey | SurveyMars
I have posted a survey titled 'UCSC Genome Browser User Satisfaction Survey' on SurveyMars. Please help me by filling it out. Thank you very much!
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Arun Durvasula @arundurvasula.bsky.social · 03/09/2025
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)
medrxiv.org
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
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Carl Zimmer @carlzimmer.com · 02/09/2025
Yesterday the president demanded that evidence about Covid vaccines be shown to the public. Today @apoorvanyt.bsky.social & I run through some of the studies made public over the past 4+ years that show that the vaccines work. Gift link: nyti.ms/46k17Tq
nyti.ms
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Fred Hutch @fredhutch.org · 24/08/2025
You're invited to the 3rd Annual BACPAC #ProstateCancer Community Research Symposium — a free event hosted by Fred Hutch Cancer Center and @uwmedicine.bsky.social, in collaboration with BACPAC and ZERO Prostate Cancer. Register: bit.ly/4fSYyv5
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W. Joel Schneider @w-joel-schneider.bsky.social · 20/08/2025
Now on CRAN, ggdiagram is a #ggplot2 extension that draws diagrams programmatically in #Rstats. Allows for precise control in how objects, labels, and equations are placed in relation to each other. wjschne.github.io/ggdiagram/ar...
An arrow with a LaTeX equationTrigonometric functions and a unit circleA bivariate change model with structured residualsA hierarchical model of cognitive abilities
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Lorenzo Lorenzo-Luaces, PhD @lluaces.bsky.social · 20/08/2025
ATTN: Robert Wood Johnson has money to support “canceled” research on racial-indigenous health equity www.rwjf.org/en/grants/ac...
rwjf.org
Rapid Response: Reinvesting in Racial and Indigenous Health Equity Research
The purpose of this call for proposals is to meet the current moment by supporting timely, actionable health equity research that has been interrupted by shifts in federal funding.
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Sam Yeaman @samyeaman.bsky.social · 20/08/2025
I'm looking to recruit a PhD student to study patterns of local adaptation and introgression across the spruce hybrid zone in the Rockies near Calgary. Projects can include field work, bioinformatics, pop gen theory, or comparison to plant/ conifer species yeamanlab.weebly.com/uploads/5/7/...
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Caroline Hu @hudrewthis.bsky.social · 20/08/2025
Seeking scientist volunteers for this fall! Want to practice science communication and help author a 🌟comic🌟 about your research? I need collaborators for the next cohort of SciComm & Comics art and design students. All countries and scientific fields eligible.
An anole extends its dewlap, which says "call for scientists!"
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Lucy D’Agostino McGowan @lucystats.bsky.social · 20/08/2025
We are hiring into 3 (THREE!) tenure track lines this year at Wake Forest — if you’re looking please reach out, I love chatting about our department! We are a vibrant group that love & embrace the teacher-scholar model 👩‍🏫
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Roshni Patel @roshnipatel.bsky.social · 18/08/2025
happy to say my new department is hiring an associate/full professor: academicjobsonline.org/ajo/jobs/30328 please apply!
academicjobsonline.org
University of Oregon, Department of Data Science
Job #AJO30328, 535565 Associate or Full Professor of Data Science, Department of Data Science, University of Oregon, Eugene, Oregon, US
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Max-Planck-Gesellschaft @maxplanck.de · 01/08/2025
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.
Open Call for Expressions of Interest in Max Planck Directorships:
Expressions of interest can be submitted until 31 October 2025.
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Mike Inouye @mikeinouye.bsky.social · 03/08/2025
ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...
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Jacquelyn Gill @jacquelyngill.bsky.social · 30/07/2025
Are you an early-career biologist or ecologist who would benefit from an invited seminar? Would you like to come to UMaine next fall or spring to give a talk? Leave a brief comment with some info about what you do. I'm co-hosting our seminar series again, and am filling out our rosters.
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Nandita Garud @nanditagarud.bsky.social · 22/07/2025
I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!
garud.eeb.ucla.edu
Garud Lab
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International Genetic Epidemiology Society @geneticepi.bsky.social · 15/07/2025
At this month's journal club, we will discuss how WES combined with arrays and imputation can match WGS in discovery power while saving time and resources. 📅 July 28, 2025 ⏰ 8 am (PDT), 11 am (EDT), 5 pm (CET) 📍 Online 📄 www.nature.com/articles/s41... Register now: msm-edu.zoom.us/meeting/regi...
nature.com
Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank - Nature Genetics
Comparison of association signals in UK Biobank using different strategies for assessing genetic variation shows that whole-exome sequencing combined with array genotyping and imputation offers simila...
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Sasha Gusev @sashagusevposts.bsky.social · 12/07/2025
I wrote a little bit about a cool recent paper looking at heritability estimates from very large registry data, and how we still really don't understand why outcomes track in families. A short 🧵:
theinfinitesimal.substack.com
We still do not understand family resemblance
...
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International Genetic Epidemiology Society @geneticepi.bsky.social · 12/07/2025
The July 2025 Pre-Conference Edition of our newsletter is out! Read it for the latest news from IGES and more details about our upcoming Annual Meeting and Education Workshop. 👉 iges.memberclicks.net/assets/2025_...
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Australian Academy of Science @science.org.au · 11/07/2025
Are you a top US-based scientist wanting to relocate to Australia? We are now calling for formal applications from both Australian and non-Australian citizens based in the US whose work is internationally recognised as exceptional. 📅 Applications close: Aug 29, 2025 🔗 science.org.au/gtap/?utm_so...
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Maitreya Dunham @maitreya.bsky.social · 11/07/2025
Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs uwhires.admin.washington.edu/ENG/candidat...
uwhires.admin.washington.edu
UW Human Resources
University of Washington Human Resources
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American Society of Human Genetics (ASHG) @geneticssociety.bsky.social · 09/07/2025
Calling #ASHGMembers! With your membership, you're eligible to apply for this 10-month advocacy training program. Visit the link below for more information and to apply before the July 18th deadline! ⤵️ #ASHG
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Norman Lee @normanlee.bsky.social · 09/07/2025
🚨We're hiring!🚨 St. Olaf is launching a new Neuroscience Major and seeks a tenure-track neuroendocrinologist to help shape its future 🧠✨ Passionate about inclusive teaching, research, and mentoring at a SLAC? Join us! #NeuroJobs @animbehsociety.bsky.social @neuroethology.org ‪@sbn-bsky.bsky.social‬
St. Olaf Tenure Track Search for a Neuroendocrinologist
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Jonathan Pritchard @jkpritch.bsky.social · 07/07/2025
Staff scientist position (computational): I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record. #sciencejobs
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Florian Privé @privefl.bsky.social · 04/07/2025
I probably won't have time to make a video out of this. But the materials are available online, and should be pretty self-explanatory. Hope this is useful to some people. privefl.github.io/statgen-cour...
privefl.github.io
Statistical Human Genetics course using R
Statistical Human Genetics course using R
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Drug Monkey @drugmonkey.bsky.social · 13/06/2025
K99 / R00 eligibility has been extended. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-121: Temporary Extension of Eligibility for the NIH Pathway to Independence Award (K99/R00)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Temporary Extension of Eligibility for the NIH Pathway to Independence Award (K99/R00) NOT-OD-25-121. OD
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Mike Inouye @mikeinouye.bsky.social · 05/06/2025
📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41... Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
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Clement Chow @clementychow.bsky.social · 03/05/2025
Repost w/ correct link! The Dept of Human Genetics at the Univeristy of Utah is hosting a Rising Stars in Genetics & Genomics postdoc symposium. We are looking to feature postdocs doing cool science! Please self nominate or nominate an excellent postdoc! #ASHGtrainees docs.google.com/forms/d/e/1F...
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Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 28/04/2025
The Department of Human Genetics at the University of Utah is sponsoring the Rising Stars in Genetics and Genomics symposium! - We are seeking nominations bu June 1. - September 18-19, 2025 - Please share with the star postdocs that you know. docs.google.com/forms/d/e/1F...
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Jeffrey Ross-Ibarra @jrossibarra.bsky.social · 09/04/2025
Regular ask to send me successful job applications, grants, and fellowships to share with others! Thanks to @isabelott.bsky.social for sharing her GRFP (and congrats!). github.com/RILAB/statem...
github.com
GitHub - RILAB/statements: Successful Job Applications and Grants
Successful Job Applications and Grants. Contribute to RILAB/statements development by creating an account on GitHub.
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Jeff Groh @jeffgroh.bsky.social · 10/04/2025
Inspired by others on here I wrote a short op-ed in support of federal research funding for a local newspaper in small town PA where I grew up
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Arslan Zaidi @aazaidi.bsky.social · 09/04/2025
An update to our preprint led by @jinguohuang.bsky.social and @nicole-kleman.bsky.social on interpreting SNP heritability in admixed populations, now with HE regression and LD Score regression in addition to GREML.
biorxiv.org
Interpreting SNP heritability in admixed populations
SNP heritability (h2snp) is defined as the proportion of phenotypic variance explained by genotyped SNPs and is believed to be a lower bound of heritability (h2), being equal to it if all causal varia...
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Mike Inouye @mikeinouye.bsky.social · 09/04/2025
This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something. Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
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Fred Hutch @fredhutch.org · 26/03/2025
After abdominal pain led her to the ER at the hospital where she works, Bekah Kooy, a general surgery physician assistant at @uwmedicine.bsky.social – Northwest, was diagnosed with a rare form of colon cancer. Read more: www.fredhutch.org/en/news/cent...
fredhutch.org
Physician assistant cares for colon cancer patients — then she became one
Bekah Kooy, 38, was convinced she had food poisoning when she felt nauseated and experienced stomach pain following lunch one day in February 2023. Within days, the general surgery physician assistant...
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Aida Andres @aidaandres.bsky.social · 21/03/2025
Interested in a starting PI position at University College London to work on Genetics, Evolution or the Environment? My department has opened the call for expressions of interest for sponsorship of independent fellowship applications. www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Steve Schwinghamer🇨🇦 @sschwinghamer.bsky.social · 15/03/2025
Hey! Are you an American considering a PhD or a postdoc, and the funding / academic situation just went absolutely bonkers? Canada's federal funding awards just added eligibility for international applicants if at Cdn institutions. www.nserc-crsng.gc.ca/NewsDetail-D...
nserc-crsng.gc.ca
NSERC - Latest News - Launch of the new Harmonized Tri-agency Scholarship and Fellowship programs
As announced in Budget 2024, the scholarship and fellowship programs administered by the three federal research funding agencies – the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC), and the Social Sciences and Humanities Research Council (SSHRC) – have been streamlined into a new harmonized talent program called the Canada Research Training Awards Suite (CRTAS) that will open for applications in summer 2025.
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Abdel Abdellaoui @dr-appie.bsky.social · 13/03/2025
I'm developing a strategic 1-on-1 game called Base Pair™ – based on biologically accurate rules 🧬🎲 Want to play and give feedback? Reply to this tweet (or RT), and I might send you a free handmade beta copy! (I have a limited nr right now, but more are on the way)
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