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Jinguo Huang

@jinguohuang.bsky.social
38 followers 55 following 0 posts

Computational biologist | Popgen/statgen, human complex traits

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Reposted by Jinguo Huang
Jonathan Pritchard @jkpritch.bsky.social · 06/01/2026
New preprint alert: we use sign errors as a test of how well TWAS works. Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇
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Reposted by Jinguo Huang
bioRxiv Genetics @biorxiv-genetic.bsky.social · 09/12/2025
Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes www.biorxiv.org/content/10.64898/20…
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Reposted by Jinguo Huang
Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 02/12/2025
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n
quinlanlab.org
Intro to Bedder – The Quinlan Lab
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Reposted by Jinguo Huang
Roshni Patel @roshnipatel.bsky.social · 01/12/2025
As promised, a longer thread on what I consider to be some of the most interesting and important contributions of this paper (1/10)
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Reposted by Jinguo Huang
Roshni Patel @roshnipatel.bsky.social · 01/12/2025
Excited to share work from my postdoc with @docedge.bsky.social and collaborators Matt Pennell and @jgschraiber.bsky.social, newly out over the weekend: www.biorxiv.org/content/10.1... (1/6)
biorxiv.org
Observational epidemiological studies can mitigate genetic confounding with the genetic relatedness matrix
Observational studies are commonly used in psychology and epidemiology to identify risk factors correlated with health outcomes. However, these studies are vulnerable to confounding when shared geneti...
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Reposted by Jinguo Huang
Sol Taylor-Brill @sol-tb.bsky.social · 13/10/2025
Excited to present my poster, “Tissue-Related Heterogeneity in Genetic Architecture of mtDNA Copy Number” (Board 5081), on Wednesday at #ASHG2025 !
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Reposted by Jinguo Huang
Nicole Kleman @nicole-kleman.bsky.social · 13/10/2025
Excited to be presenting my poster “Residual Stratification and Increased Genetic Diversity in Multi-ancestry GWAS”, Board 1062T on Thursday, October 16 from 2:30pm-4:30pm at #ASHG2025!
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Reposted by Jinguo Huang
Arslan Zaidi @aazaidi.bsky.social · 25/05/2025
Our paper on the theoretical properties of SNP heritability in admixed populations is out in Genetics: academic.oup.com/genetics/adv... with @jinguohuang.bsky.social, @nicole-kleman.bsky.social , Saonli Basu, and Mark Shriver
academic.oup.com
Interpreting SNP heritability in admixed populations
Abstract. SNP heritability (h2snp) is defined as the proportion of phenotypic variance explained by genotyped SNPs and is believed to be a lower bound of h
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Reposted by Jinguo Huang
Arslan Zaidi @aazaidi.bsky.social · 09/04/2025
An update to our preprint led by @jinguohuang.bsky.social and @nicole-kleman.bsky.social on interpreting SNP heritability in admixed populations, now with HE regression and LD Score regression in addition to GREML.
biorxiv.org
Interpreting SNP heritability in admixed populations
SNP heritability (h2snp) is defined as the proportion of phenotypic variance explained by genotyped SNPs and is believed to be a lower bound of heritability (h2), being equal to it if all causal varia...
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