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Professor Lesley Hoyles

@bugsinyourguts.bsky.social
2K followers 405 following 645 posts

And all this science I don't understand, it's just my job five days a week. Professor of Microbiome and Systems Biology @ Nottingham Trent University. 🏳️‍🌈 Working predominantly on the human gut microbiota. All views my own.

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Reposted by Professor Lesley Hoyles
Prof Jenny Rohn @jennyrohn.bsky.social · 6h
If you are in the UK right now and have clear skies, #aurora is visible on camera! Should be a good night!
Faint strength of rosy aurora over a dark horizonScreenshot from the Glendale app showing lots of green ticks on the UK map
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Reposted by Professor Lesley Hoyles
Lavisha Parab @lavishaparab.bsky.social · 07/10/2026
hello #phage pholks, any of you already have a protocol for high-through put one-step growth curves? Making any step faster/more convenient is welcome. Thanks!!! Spotting on a big agar plate doesn't save as much time as we lose by reducing the precision/least count and then having to repeat it 😅
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Micah @rincewind.run · 07/10/2026
rip to one of the coolest software engineers who ever lived
Margaret Hamilton standing next to a printout of code she and her team wrote for the Apollo program, which is as tall as she is
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Pavel Payne @pavelpayne.bsky.social · 07/10/2026
Finally, my paper is out! It shows how bacteria can utilize their CRISPR immunity against transducing phages to turn them into "pollinators". This way bacteria can speed up their own adaptation through recombination by two orders of magnitude compared to mutations, and they do so when starving!
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 07/10/2026
@davidnegus.bsky.social
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 06/10/2026
I’m excited to be speaking at The Festival of Genomics & Biodata, taking place on 27-28 January 2027 at ExCeL London. Registration is free for over 90 % of attendees: sign up now to join me in January! hubs.la/Q04z76nC0 #FOG2027 #genomics #biodata #microbiome
hubs.la
The Festival of Genomics and Biodata London
The UK’s largest Life Sciences event returns to London
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Reposted by Professor Lesley Hoyles
Dave Baltrus 🦦 @surtlab.bsky.social · 05/10/2026
In case you hadn’t heard, the lab acquired case is an incredible and sad story The researcher working w/ attenuated strain at BSL2. Strain attenuated by disabling ability to acquire sufficient iron in hosts The researcher unknowingly had rare genetic disorder where their body had >iron levels
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 05/10/2026
TFW a new student replicates findings from a published study by creating their own code from the supplementary material without any guidance.
static.klipy.com
Rainbow Dancing Unicorn
Alt: Rainbow Dancing Unicorn, to celebrate having an exceptional student. :)
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 04/10/2026
WANT.
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Richard Jones @richardaljones.bsky.social · 02/10/2026
I don’t think this headline is a fair reflection of my piece, which argued that some RD&I funding at the innovation end should be devolved, while funding for discovery science & national priorities should be retained by UKRI. Full piece here: softmachines.org?p=3364
softmachines.org
On the devolution of Research, Development and Innovation funding: some tentative principles – Soft Machines, by Richard Jones
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 29/09/2026
Is that where Nature shunts papers now?
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 25/09/2026
static.klipy.com
Chefs Kiss French Chef
ALT: Chefs Kiss French Chef
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 25/09/2026
Such a rare finding. AI truly is the future.
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 25/09/2026
When you need access to the magic buzzword list... Bleak.
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Imperial MRC DTP @imperialmrcdtp.bsky.social · 24/09/2026
15 new 1+3 MRC Doctoral Landscape Award studentships @imperialcollegeldn.bsky.social in medical research funded by the @The_MRC commencing October 2027. Admissions will open open 14 October 2026. #phd, #medicalresearch www.imperial.ac.uk/medicine/stu...
imperial.ac.uk
HealthBRIDGE
HealthBRIDGE is an exciting and innovative 1+3-year PhD training initiative designed to improve human health and drive UK economic growth funded by t...
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Reposted by Professor Lesley Hoyles
Willem van Schaik @wvschaik.bsky.social · 24/09/2026
Amazing opportunity for post-doctoral researchers to move to the UK 'MOBILITY offers 6 outstanding postdoctoral researchers a 5-year opportunity to develop their own ambitious research programme at University of Birmingham' www.birmingham.ac.uk/about/colleg...
birmingham.ac.uk
MOBILITY - University of Birmingham
Retaining Europe's brightest researchers to drive the next generation of life science breakthroughs.
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Nick Loman @pathogenomenick.bsky.social · 22/09/2026
Folks - if you're interested in how machine learning/AI can be used for microbial genomics, microbiome and metagenomics studies - please join us for a workshop in Birmingham on Thursday 8th October organised with CLIMB & NVIDIA. www.climb.ac.uk/blog/2026/09...
climb.ac.uk
Call for Applications: GPU-Accelerated Computing for Microbiome and Metagenomic Research · CLIMB
CLIMB is a cloud computing infrastructure for microbial bioinformatics — notebook servers, shared storage and reproducible workflows for genomics, metagenomics and pathogen surveillance researchers ac...
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Guillaume Méric @gmeric.bsky.social · 22/09/2026
We have a ✨PhD studentship✨ on olfactory genetics and the gut microbiota supervised by Dr Kaitlin Wade @bristoluni.bsky.social /Bristol Med School & me @uniofbath.bsky.social → Check it out! (incl GW4 selection process, eligibility & target candidate profiles) www.findaphd.com/phds/project...
findaphd.com
GW4 BioMed3 MRC DLP PhD project: Understanding the impact of olfactory genetics, diet and gut microbiota on cardiometabolic health at University of Bath on FindAPhD.com
PhD Project - GW4 BioMed3 MRC DLP PhD project: Understanding the impact of olfactory genetics, diet and gut microbiota on cardiometabolic health at University of Bath, listed on FindAPhD.com
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Reposted by Professor Lesley Hoyles
Jay Edidin @edidin.bsky.social · 23/09/2026
One of my favorite cases of someone being Wrong on the Internet was a very earnest, very confused vegan who was telling people how cruel honey is; and it eventually turned out they thought honey was made by putting bees in a centrifuge and spinning them around until they threw up.
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Dr Geertje van Keulen @drgvank.bsky.social · 22/09/2026
Can anyone provide me pls with a pdf for Levin, P.A., Wang, J.D. Bacterial growth rate in populations and single cells. Nat Microbiol (2026). doi.org/10.1038/s415... #Icanhazpdf #thnx!!
doi.org
Bacterial growth rate in populations and single cells - Nature Microbiology
In this Perspective, Levin and Wang give a brief history of bacterial growth rate and discuss how it is connected to nutrient availability and macromolecule synthesis, with a focus on (p)ppGpp as a ce...
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David Bikard @dbikard.bsky.social · 21/09/2026
New paper from the lab, out in Nature Microbiology. We ran CRISPRi screens to ask what genes E. coli needs in order to live in a gut and what this can tell us about the gut environment itself. doi.org/10.1038/s41564-026-02471-8
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 21/09/2026
@hetgajjar03.bsky.social @devarsh1917.bsky.social
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Prof Jenny Rohn @jennyrohn.bsky.social · 21/09/2026
Please do consider applying for this exciting lab role with @gpollara.bsky.social and me - nice blend of advanced culture models, immunology, microbiology and ‘omics, in our friendly Central London labs. Closes 2 Oct, please amplify! Happy to chat informally #UTI #UTISky
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FEMS @femsmicro.org · 18/09/2026
Could you be the next FEMS Outstanding Early Career Microbiologist Awardee? This award recognises exceptional ECR making significant contributions. ✅ Free registration to #FEMSMICRO 2027 ✅ Travel grant ✅ Oral presentation ⏰ Apply by 30 Sept 🔗 buff.ly/cw9DyvB
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Snorre Sulheim @sulheim.bsky.social · 18/09/2026
Finally online! Cross-feeding enables robust coexistence between four bacterial species | PNAS www.pnas.org/doi/10.1073/... #microsky
pnas.org
Cross-feeding enables robust coexistence between four bacterial species | PNAS
Resource supply is generally considered a dominant driver of microbial diversity. Here, using a four-species bacterial consortium, we asked whether...
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Reposted by Professor Lesley Hoyles
Alan Walker @faecalmatters.bsky.social · 17/09/2026
Formal announcement of the 15th installment of the International Gut Microbiology Symposium series, running from June 1st to 3rd 2027: www.abdn.ac.uk/events/confe... We will look forward to welcoming old friends and new to Aberdeen next summer.
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Nichole Broderick, PhD @nabroderick.bsky.social · 16/09/2026
Society journals support the scientific community, including advocacy for funding and science policies. $ to for profit journals just ends up in another shareholders yacht.
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Reposted by Professor Lesley Hoyles
Darren Dahly @statsepi.bsky.social · 15/09/2026
Rightly so. cc @wiringthebrain.bsky.social @deevybee.bsky.social www.the-scientist.com/wellcome-s-5...
the-scientist.com
Wellcome’s $50M Microbiome-Autism Project Gets a Serious Gut Check | The Scientist
A massive research program investigating causal links between the gut microbiome and autism sparked fierce pushback from scientific critics and advocacy groups.
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 15/09/2026
@devarsh1917.bsky.social @hetgajjar03.bsky.social
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Reposted by Professor Lesley Hoyles
Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 15/09/2026
ICYMI: New online! Drug–microbiome–host interactions: antimicrobial effects of non-antibiotic compounds
dlvr.it
Drug–microbiome–host interactions: antimicrobial effects of non-antibiotic compounds
Nature Reviews Gastroenterology & Hepatology, Published online: 14 September 2026; doi:10.1038/s41575-026-01258-wMany compounds not classified as antibiotics can exert antimicrobial activity, with drug–microbiome–host interactions having profound effects on the human microbiome and human health. This Review explores how non-antibiotic compounds exert these antimicrobial effects, highlighting which compounds can influence the microbiome, the underlying mechanisms, and implications for translation and clinical practice.
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Reposted by Professor Lesley Hoyles
Quiet Majority @majorityquiet.bsky.social · 11/09/2026
We loved this so much we just had to put English subtitles on it, apologies to the French speakers for our translation. But this is what it would look like here in the UK if Farage or Lowe or another of their ilk got their own way.
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Alexis Stamatakis @stamatak.bsky.social · 12/09/2026
The RAxML-NG v2.0 preprint is out: www.biorxiv.org/content/10.6... v2.0 features integrated model testing, fast branch support metrics, automatic parallelization, phylogenetic difficulty prediction, genotype evolution models, to name but the most important features. And it is A LOT FASTER of course
biorxiv.org
RAxML-NG 2: Automatic model selection, novel tree search heuristics, and fast branch support metrics
RAxML-NG is a widely used tool for maximum likelihood based phylogenetic inference. In the seven years since the last RAxML-NG publication, we have continuously improved and extended the code. Here, w...
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Reposted by Professor Lesley Hoyles
Alex von Tunzelmann @alexvont.bsky.social · 10/09/2026
If you feel like donating to the RNLI, here’s a link. I just have. Their minimum donation is £2: I think it might be nice for them to receive a lot of donations this week, even if they’re mostly very modest. Just so they know a lot of people out here appreciate their work. rnli.org/support-us/g...
rnli.org
Donate to the RNLI and help save lives at sea
Your donations really make a difference. We depend on your generosity to educate people to stay safe and prevent tragedies on and offshore. Donate here.
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Reposted by Professor Lesley Hoyles
David Sünderhauf @davvi36.bsky.social · 10/09/2026
Please share! We are looking for a PhD student excited about gene transfer, and tackling Antimicrobial Resistance in Klebsiella pneumoniae. 🧬 More details & applications on funder website by 21st Oct 👇🏻 gw4biomed.ac.uk/developing-c...
gw4biomed.ac.uk
Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae - GW4 BioMed MRC DTP
Project Code IIAR27Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Antimicrobial resistance (AMR) poses a major thre...
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Prof Jenny Rohn @jennyrohn.bsky.social · 09/09/2026
So not surprising, eh @microberamon.bsky.social @friendlymicrobe.bsky.social ?
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Will Matlock @wtmatlock.bsky.social · 09/09/2026
Does an AMR gene on a plasmid diversify differently to an AMR gene on a chromosome? We are looking for a PhD student to work on this question in Bath!
gw4biomed.ac.uk
Turning up the volume: plasmid copy number and gene duplications as drivers of antimicrobial resistance evolution - GW4 BioMed MRC DTP
Project Code IIAR27Ba Matlock Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Plasmids are important drivers of antimicrobial res...
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 09/09/2026
Thanks, Michael. I'll submit an issue report via github. Essentially, the web page won't recognize protein fasta files (keeps saying they're nt, or that the header format is wrong).
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 09/09/2026
Anybody know where to report issues associated with the web page for eggNOG-mapper 3? Or does everything go through the github for the stand-alone version? cc @borklab.bsky.social
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Dr Alfredo Carpineti @drcarpineti.bsky.social · 08/09/2026
To properly mark the 60th of #StarTrek, I wrote about the franchise's impact beyond science. If you want an article that features international relations, memes, suspension of democratic norms, and Heated Rivalry, this is the one for you: www.iflscience.com/star-trek-at...
iflscience.com
Star Trek At 60 – The Iconic Franchise Changed More Than Science, It Changed Society
We focus on tablets and voice-activated computers, but the series has had and continues to have a much wider impact.
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 03/09/2026
@devarsh1917.bsky.social @hetgajjar03.bsky.social
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Gerry Tonkin-Hill @gerrythill.bsky.social · 02/09/2026
Glad to share StrainSpy, a new method developed by Sudaraka and co which identifies strain-level associations in metagenomics using ANI estimates from tools like Sylph. www.biorxiv.org/content/10.6...
biorxiv.org
Accurate detection of metagenomic strain-level associations using average nucleotide identity with StrainSpy
Genetic variation among microbial strains of the same species can profoundly influence their phenotypes, ecological functions, and impacts on human health. Traditionally, the relative abundance of a s...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 31/08/2026
Metabolite co-variation networks reveal keystone functions and an emergent pathogen state in the human urobiome. www.biorxiv.org/content/10.64898/20…
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Simon McArthur @drsimonmcarthur.bsky.social · 28/08/2026
Happy to share our latest publication! 🧪🧠 doi.org/10.1111/ejn.... We found that brief, repeated isoflurane anaesthesia, a common feature of many longitudinal preclinical studies, can induce significant behavioural, vascular and neuroimmune effects in adult mice...
doi.org
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Applied Microbiology International @amiposts.bsky.social · 27/08/2026
#MMEG2026: Submit an abstract 📊 We welcome abstract submissions relating to molecular microbiology and microbial ecology. Researchers at all career stages are encouraged to submit their work. Submit by 27 September 2026: appliedmicrobiology.org/ems-event-ca...
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Willem van Schaik @wvschaik.bsky.social · 27/08/2026
Researchers celebrate Dolly Parton's contributions to science The country singer was an advocate for vaccines, public health, literacy and marginalized communities. www.nature.com/articles/d41...
nature.com
Dolly Parton dies aged 80 – researchers celebrate her contributions to science
The country singer was an advocate for vaccines, public health, literacy and marginalized communities.
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Alex Zalben @azalben.bsky.social · 25/08/2026
Dolly Parton, among a thousand other amazing things she did in her life, gifted over 330 million books to kids through her Imagination Library program. Her passing is a tremendous loss to the world, but you can support the program today to keep it going imaginationlibrary.com
imaginationlibrary.com
Dolly Parton's Imagination Library | USA, UK, IE, CA, AU
Dolly Parton’s Imagination Library is a book gifting program that mails free books to children from birth until they begin school in participating areas.
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Drug Monkey @drugmonkey.bsky.social · 25/08/2026
From literacy for children to helping make the covid vaccine a reality, Dolly Parton was just a damn good person. A sad day. Rest in Power.
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Amadi Lovelace @amaditalks.bsky.social · 25/08/2026
Remember that if you got the Moderna Covid vaccine, you have Dolly Parton to thank, she gave the largest individual contribution toward their research to make it possible.
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Nancy Moran @nancy-moran.bsky.social · 24/08/2026
Insights into the role of a genotoxin in nature, through the lens of a honeybee gut. Colibactin stabilizes a symbiont community and keeps out invaders... Congratulations to Yulin Song and other authors! rdcu.be/fBIeq or (subscription) www.nature.com/articles/s41...
rdcu.be
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 24/08/2026
Completely agree. The amount of money spent on low-biomass metagenomics is ridiculous, especially once human DNA is involved.
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