A deep-tissue light source made from mechanoluminescent transducers stimulated by focused ultrasound enables wide imaging of live animal vasculature, and modulation of neuronal activity and behaviour.

Gene correction in the lung is achieved with inhalable mRNA lipid nanoparticles containing an amino acid-derived ionizable lipid identified from screening and structure–function optimization studies.

A bioelectronic device incorporating triphylite (LiFePO4) as electrode is used for lithium-ion-specific inhibition of peripheral and central nervous system activities in rats and in mice.

Active wetting and fluidification of breast cancer epithelia are shown to be controlled by IRSp53 and Afadin, cell adhesion proteins that regulate multicellular viscosity and tensile state during tumo...

Lipid nanoparticles incorporating a crosslinked ionizable lipid are shown to promote efficient endosomal escape of antigen mRNA and glycolysis stimulation in dendritic cells, to elicit robust vaccinat...

A tunable granular biomaterial matrix is developed to support long-term bioprinting. Stress relaxation at high strains and long timescales is shown to be important for tissue self-organization in inte...

An injectable pH-sensitive nanoadjuvant is shown to induce effective pyroptosis of tumours, which, combined with the in situ photoactivable release of TLR agonists, generates a strong vaccine-like res...

Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

A probe with month-long molecular afterglow luminescence targeting a downregulated cancer biomarker detects small liver tumours for image-guided resection in mice and rabbits.

Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...

The viscosity of tumour cells is shown to govern their ability to disseminate through the bloodstream and extravasate, establishing a key biomechanical factor of metastasis.

Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...

Two-dimensional molybdenum disulfide (MoS2)-based active arrays made by growing wafer-scale trilayer MoS2 directly on a polyimidine substrate achieve high-fidelity spatiotemporal neuronal monitoring i...

Photonic technologies enable on-chip, scalable solutions for applications in quantum communications, quantum sensing and quantum computing.See Wang et al.

Human primary monocytes reversibly phase separate into regular, multicellular, multilayered domains on soft matrices with physiological stiffness due to local activation and global inhibition processe...

Human primary monocytes reversibly phase separate into regular, multicellular, multilayered domains on soft matrices with physiological stiffness due to local activation and global inhibition processe...

Polymer-coated liposomes specifically target and deliver interleukin-12 to metastatic ovarian cancer, strongly sensitizing the tumours to combination therapy with immune checkpoint inhibitors.

A focused-ultrasound-mediated mechanogenetics approach enables the genetic modification of cancer cells near solid tumours to activate chimeric antigen receptor T cell response and achieve tumour supp...

Title: Associate or Senior Editor, Nature Materials Organization: Nature Portfolio Locations: New York, Jersey City, Shanghai or Beijing Application Deadline: October 13th, 2025 About Springer Nature ...

Trial in China is one of the first times the immune therapy has worked against solid tumours.

Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get the powerful therapy to more people.

Organoid avatars of colorectal cancer and its microenvironment model immune interactions and drug efficacy.

Electric fields guide collective cell migration in developing embryos of Xenopus laevis via a voltage-sensitive phosphatase.

SAVE THE DATE!Join biologists, bioengineers, clinical researchers, and industry professionals in Belgrade on 28-29 October for a cutting-edge conference focused on the design of human-relevant disease...

This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...

The ruling temporarily halts a policy slashing research overhead costs in 22 states, which filed a lawsuit against the biomedical agency.

The mass-archiving effort is in response to the US Centers for Disease Control and Prevention removing some of its web pages.

Societies should learn from this and speak up to support inclusion

If the 193 remaining member nations want the WHO to succeed, they must find a way to pay for it.

In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their prog...