The integrity of evidence synthesis is threatened by problematic randomised controlled trials, where there are serious concerns about the trustworthiness of the data or findings. Such concerns could b...

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In cluster-randomised trials (CRTs), different estimands can be targeted, such as the individual- or cluster-average effect. These two estimands can differ in magnitude when outcomes or treatment effe...

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An introductory 2-hour online workshop will introduce participants to the INSPECT-SR tool for assessing trustworthiness of randomised controlled...

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This Viewpoint discusses some specific challenges in defining estimands for cluster randomized trials and illustrates how the CRT-Estimands Framework can be applied to improve the interpretation of tr...

YouTube video by Richard_D_Riley

There are no negative trials - just ones we learn from and ones we don't

Future directions in the evaluation of innovative technologies in healthcare: Technology in healthcare is rapidly advancing. For example, a recent healthcare report suggests that 9 out of 10

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While the use of estimands in randomized trials is increasing, there is little guidance on which intercurrent event strategies should be used. The article by Fleming et al. seeks to address this gap....

This commentary offers perspectives on delivering “rigorous causal inference on meaningful estimands” that differ from the opinions recently shared by Fleming et al. We (1) depict a more robust pathw...

Open Access book by Luc Smits, Sander van Kuijk, and Laure Wynants: This open-access textbook offers a practical and comprehensive guide to developing, validating, and implementing clinical prediction...

This commentary offers perspectives on delivering “rigorous causal inference on meaningful estimands” that differ from the opinions recently shared by Fleming et al. We (1) depict a more robust pathw...

While the use of estimands in randomized trials is increasing, there is little guidance on which intercurrent event strategies should be used. The article by Fleming et al. seeks to address this gap....

While the use of estimands in randomized trials is increasing, there is little guidance on which intercurrent event strategies should be used. The article by Fleming et al. seeks to address this gap....

‘Real-world’ evidence (RWE) and related terms are gaining popularity in scientific literature, usually in reference to evidence collected outside of traditional randomized controlled trials (RCT). How...

Health researchers need to fully understand the underlying assumptions to uncover cause and effect. Timothy Feeney and Paul Zivich explain Physicians ask, answer, and interpret myriad causal question...

In clinical trials, postrandomization events, such as treatment discontinuation or the use of rescue medication, can complicate the interpretation of results. An estimand is a precise description of t...

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Background An estimand is a precise description of the treatment effect a trial is aiming to find out. We previously identified that public partners (defined as patients and/or members of the public w...

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