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brian_delisle

@bpdelisle.bsky.social
1.5K followers 2.1K following 120 posts

Prof of Physiology; Heart Disease; Cardiac EP; LQTS; Ion Channels; Biophysics; Chronobiology; Reviewer 2; He, him, his; Opinions/retweets/likes are my own orcid.org/0000-0002-2146-327X

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bioRxivpreprint @biorxivpreprint.bsky.social · 29/09/2026
The circadian clock regulates KCNH2 (hERG) promoter activity through daily temperature rhythms. www.biorxiv.org/content/10.64898/20…
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bioRxiv Physiology @biorxiv-physio.bsky.social · 29/09/2026
Light-cycle time-restricted feeding remodels a hidden layer of the cardiac transcriptome through sex-specific transcript switching www.biorxiv.org/content/10.64898/20…
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Helen Collins @drhelenecollin1.bsky.social · 24/04/2026
Checking out this talk from Shrishti Naidu from the University of Kentucky on sex differences in the cardiac transcriptome. Great session so far! #APS2026 #APSSummit
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Levental Lab @leventallab.bsky.social · 24/01/2026
Excited to share a new story that transformed how we think about membrane domains in the ER! rdcu.be/eR7Cn ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export Wondering what’s so new and exciting? Skytorial below! 1/9
rdcu.be
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export
Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...
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brian_delisle @bpdelisle.bsky.social · 16/01/2026
🚨🆕🧪🔬 Congrats to @abhiprabhat.bsky.social - dim light at night exacerbates cardiac autonomic neuropathy (CAN) in diabetic mice & CAN disrupts coupling between heart rate and body temp 🫀⏱️ #CardiacAutonomics #Diabetes #Circadian #Physiology #CardioSky www.heartrhythmjournal.com/action/showP...
Graphs showing data of heart rate and core body temperature in control and diabetic mice.
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brian_delisle @bpdelisle.bsky.social · 17/12/2025
🚨 🤯 new 🔬by @krishnanyamuna.bsky.social “… pH gradients exist within single, large or long organelles… ER..mitochondria..nucleolus..prompting new questions about proton diffusion.. on organelle function.” www.biorxiv.org/content/10.6... Now I have update my Cell lectures for Spring- very 😎
Image of Mito matix pH with scale
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Yamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
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NEJM.org @nejm.org · 19/11/2025
A new review summarizes the genetics, diagnosis, and treatment of long QT syndrome, a major cause of sudden death in young people. Risk stratification and genotype-guided therapy are essential. Learn more in a new Review Article: nej.md/44cxXnN #MedSky #CardioSky
Review Article 
Long QT Syndrome 

Figure 1. ECG Patterns Suggestive of Long QT Syndrome.
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brian_delisle @bpdelisle.bsky.social · 15/11/2025
🚨🆕🧪🔬 Hyperglycemia 👊🏻 the brain hard 🧠🔥 Miao, Mohiuddin et al shows GLUT1 is essential for brain endothelial cell survival under high glucose, w/o it, cells lose homeostasis and barrier function yikes😧 #Neurovascular #Diabetes #Physiology journals.physiology.org/doi/full/10....
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brian_delisle @bpdelisle.bsky.social · 11/11/2025
🚨🆕🧪🔬That “wild-type” Nav1.5 variant everyone’s been using may not be so WT after all. Melgari et al. reveal T559A causes loss-of-function ⚡️❌ decades of WT controls weren’t truly WT, time to double-check those studies🧐🧬 #IonChannel #Physiology #Reproducibility journals.physiology.org/doi/full/10....
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brian_delisle @bpdelisle.bsky.social · 10/11/2025
🚨🆕🧪🔬 Not all gut-brain signals follow the clock🕒🥣 Arnold and colleagues show CCK receptors + signaling in vagal afferents stay steady across day & night 🌞🌙 despite circadian rhythms 🧠➡️🍽️ #GutBrainAxis #Circadian #Physiology #Neuroscience journals.physiology.org/doi/full/10....
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brian_delisle @bpdelisle.bsky.social · 09/11/2025
If you are at #AHA25 go check out Dr. Prabhat’s @abhiprabhat.bsky.social poster- where he identifies feeding behavior as a potential modifiable risk factor for regulating autonomic input to the heart- It is TODAY 11:30am-12:30pm (Central) MC.APB.04 eppro02.ativ.me/web/index.ph... #heart #CardioSky
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brian_delisle @bpdelisle.bsky.social · 09/11/2025
🚨🆕🧪🔬on 💓🕒 Delisle et al. 😉show the circadian clock gene BMAL1 drives sex-specific daily patterns in cardiac ion channels ⚡️❤️‍🔥 in 🐭, shaping when arrhythmias may strike in males vs females 🧠➡️❤️ #Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky www.sciencedirect.com/science/arti...
sciencedirect.com
BMAL1 mediates sex-specific circadian regulation of cardiac ion channels and temporal arrhythmia vulnerability
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Beth Schroder @bethaschroder.bsky.social · 02/11/2025
Thrilled to share our Creative Concepts paper published in Heart Rhythm on how the circadian clock gene Bmal1 mediates sex specific cardiac ion channel expression. authors.elsevier.com/a/1m1jJ5VtUy... @kaesser.bsky.social @bpdelisle.bsky.social @abhiprabhat.bsky.social
authors.elsevier.com
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brian_delisle @bpdelisle.bsky.social · 19/07/2025
🚨 🆕 🔬 💥 Suzuki et al reveal Kir2.1 channels hyperpolarize macrophages, crank up CRAC channel–mediated Ca²⁺ entry ⚡and migration w/o touching phagocytosis or M2 polarization 🧫 It’s all about that K⁺ flow and CaMK–Pyk2 activation🧠🔥#Physiology #IonChannels 👉 journals.physiology.org/doi/full/10....
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brian_delisle @bpdelisle.bsky.social · 19/07/2025
🚨 🆕 🫀🔬🔥 Wang et al: Asprosin 💥 protects the diabetic heart by dialing down overactive autophagy via the AMPK/mTOR/ULK1 pathway 🧬 No Asprosin = more fibrosis & more apoptosis 😱 💉🧠 #CardioSky #Physiology #autophagy 👉 journals.physiology.org/doi/full/10....
journals.physiology.org
Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway | American Journal of Physiology-Cell Physiology | American Physiological Society
Aberrant autophagy mediated by AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/unc-51 like kinase 1 (ULK1) pathway (a canonical autophagy pathway) plays important roles in dia...
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brian_delisle @bpdelisle.bsky.social · 18/07/2025
🚨 🆕 🔬 Pereira Jr. et al. show that MitoKATP channels are vital for brown adipocyte 🔥 growth—but are switched off for thermogenic blast 💥 in mature cells. Cold? NE? Block the channel, burn the fuel. ❄️🧬 👉 journals.physiology.org/doi/abs/10.1... #IonChannels #Physiology
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brian_delisle @bpdelisle.bsky.social · 16/07/2025
🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1... #Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
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brian_delisle @bpdelisle.bsky.social · 16/07/2025
🚨 New 💪 🔬 Naughton et al. reveal NOMO as a force-bearing ER protein that shapes ER structure & drives muscle cell fate—Its Ig-domain handles piconewton-scale tension, delete it, and myogenesis breaks down 🧬 🔧👉 rupress.org/jcb/article/... #Physiology #Cell #Science #Muscle
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Hao Yin @haoyin.bsky.social · 07/06/2025
Bhlhe40 (a known negative regulator of BMAL/CLOCK activity) as a transcriptional activator of SMC-to-foam cell transition in #Atherosclerosis Ldlr-/- Myh11-CreERT2 ROSA26-ZsGreen1🐭 CITE-seq (119 Ab) Only 1~3% (Not 30%!) Mφ-like cells are SMC-derived 🤓 bioRxiv 2025 www.biorxiv.org/content/10.1...
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The Physiological Society @physoc.bsky.social · 29/05/2025
📢 Final call! Submit your abstracts to present your research at our meeting, ‘Cross-Talk of Cells in the Heart 2025’ at the University of Birmingham on 3-4 Sept. Showcase your findings on the mechanisms of heart disease and arrhythmias. 📝 Submit by 2 June ⬇️
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Cross-Talk of Cells in the Heart 2025: Novel Mechanisms of Disease and Arrhythmias
Cross-Talk of Cells in the Heart 2025, an exciting two-day meeting at University of Birmingham (UK) to discuss the latest breakthroughs in cardiac arrhythmia and disease research. Join us
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Karyn @kaesser.bsky.social · 11/05/2025
Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...
cell.com
Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia
Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological functions. They reveal cance...
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Ken Campbell @cardiaccampbell.bsky.social · 10/05/2025
Excited to see (newly Dr) Greg Milburn's paper on cardiac amyloidosis in human myocardium with cell-level mechanics, histology, and gel-based analysis of sarcomeric proteins. Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis doi.org/10.1016/j.ja...
Graphical abstract - cell mechanics, histology and western blots.
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Maria de la Paz Fernandez @mariadelapax.bsky.social · 07/05/2025
We are very pleased to share that our paper on sexual dimorphism in circadian rhythms has been published in @plosbiology.org. This work was led by the very talented Aishwarya Iyer and includes contributions from three undergraduate co-authors. You can read the full study here:
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Mary Feeney @mkfeeney.bsky.social · 24/04/2025
For the last 3 yrs, I was the director for the Science of Science program at the NSF. We funded projects on science communication - science communication to the public, communication of public priorities to scientists, citizens engagement & participation in science. 🧵
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Yamuna Krishnan @krishnanyamuna.bsky.social · 24/04/2025
Please read this.
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Ali D. Güler @aguler.bsky.social · 18/12/2024
GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15
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APS Publications @apspublications.bsky.social · 03/04/2025
#FreeToRead 👀 CONGRATULATIONS! An ovary-intact #postmenopausal #HFpEF mouse model; #menopause is more than just #estrogen deficiency Mei Methawasin, et al. ➡️doi.org/10.1152/ajph...
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The Journal of Physiology @jphysiol.bsky.social · 01/04/2025
David J Paterson of @oxforddpag.bsky.social & Kalyanam Shivkumar of @uclaupdates.bsky.social present this preface #Editorial for our latest special issue 'Cardiac Neurobiology: Concepts to Clinic' which is dedicated to Jeffrey L. Ardell (1952–2025) 📜 physoc.onlinelibrary.wiley.com/doi/full/10....
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htw @heniek-htw.bsky.social · 02/04/2025
Diet-induced obesity dampens temporal oscillation of hepatic mitochondrial lipids Our study revealed that obesity altered the mitochondrial lipid composition & hampered the rhythmicity of mitochondrial lipids, oxygen consumption rate & Parkin levels in liver www.sciencedirect.com/science/arti...
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APS Publications @apspublications.bsky.social · 01/04/2025
🔓Editorial From Timothy Musch et al. “APS Initiatives and Milestones: a Year in Review and a Look Ahead” ➡️doi.org/10.1152/phys...
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brian_delisle @bpdelisle.bsky.social · 30/03/2025
🚨🆕🔬Eosinophil clocks disrupted with asthma? Teppan et al show that disrupted circadian clocks in eosinophils fuel airway inflammation 🫁 Resetting the clock with a ROR inhibitor ⬇️ mucus, ⬆️ lung function👉 journals.physiology.org/doi/pdf/10.1... #Physiology #Science #Circadian #Asthma
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Jeff Greene @jeffgreene.bsky.social · 29/03/2025
Unsurprisingly, @tressiemcphd.bsky.social is spot-on in this analysis: “A.I.’s most revolutionary potential is helping experts apply their expertise better and faster. But for that to work, there has to be experts.” www.nytimes.com/2025/03/29/o...
nytimes.com
Opinion | Actually, A.I. Is Pretty Mid (Gift Article)
A.I. is just what we need in the post-fact era: less research and more predicting what we want to hear.
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htw @heniek-htw.bsky.social · 30/03/2025
Common hallmarks and potential mechanisms linking cancer, circadian rhythms, and aging.
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htw @heniek-htw.bsky.social · 29/03/2025
•Night shift work is associated with increased inflammation •HDL-C levels are decreased among night shift workers •Night shift workers have prolonged heart rate-corrected QT intervals •HDL-C & QTc are promising indicators of CVD risk among night shift workers www.sciencedirect.com/science/arti...
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 29/03/2025
For a presentation I am giving, I made a wordcloud of the titles of the NIH grants that were canceled. It is clear about the unscientific goals of this administration
a word cloud of the titles of canceled NIH grants with gender and minority being that largest words
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brian_delisle @bpdelisle.bsky.social · 29/03/2025
🚨🆕🔬Three meals, same calories, different metabolism 🧬 Dörner et al show that our bodies shift from🔥carbs in the morning to fat by dinner- Glucose handling dips 📉 but metabolic resilience rises📈 w/ triglyceride use 👉 journals.physiology.org/doi/abs/10.1... #Physiology #Science #Circadian #Metabolism
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Billy Hanlon @bhanlon15.bsky.social · 28/03/2025
NHK, Japan: 'Cracking the Complexity of Long COVID: Akiko Iwasaki / Professor of Immunobiology, Yale University' 'She talks about breakthroughs in understanding Long COVID, and the importance of diverse voices in science' www3.nhk.or.jp/nhkworld/en/...
www3.nhk.or.jp
Cracking the Complexity of Long COVID: Akiko Iwasaki / Professor of Immunobiology, Yale University - Direct Talk | NHK WORLD-JAPAN
Dr. Akiko Iwasaki has devoted her career to studying vaccines, to ward off infectious diseases. She talks about breakthroughs in understanding Long COVID, and the importance of diverse voices in scien...
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 27/03/2025
“DOGE and HHS will determine whether a particular NOFO can be published, even if it has already been approved by an NIH advisory council of independent scientists who normally review such programs…’How is that decreasing regulation/bureaucracy?’” www.science.org/content/arti...
science.org
Trump officials will screen NIH funding opportunities
Staff at biomedical agency worry about political interference in setting priorities
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The Journal of Physiology @jphysiol.bsky.social · 25/03/2025
This recent #JournalClub by Federico Picciau @universitypost.bsky.social et al. examines the impact of exercise intensity on #neurogenesis and the work of Lambertus et al. (2024) 🧠 🏃 ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...
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APS Publications @apspublications.bsky.social · 25/03/2025
📣 Did you hear the news? @apspublications.bsky.social reached our #SubscribeToOpen goals for 2025! Authors, find out how you can publish open access with APS #S2O journals.physiology.org/s2o-content-...
journals.physiology.org
Subscribe to Open: How We Will Make Articles in 2025 Issues Open Access
APS is transitioning to Open Access via Subscribe to Open. Learn what to expect, how we are updating content, and how you can share feedback on this process.
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Antony Dodd @antdodd.bsky.social · 21/03/2025
Really enjoyable Clock Club today at the University of Warwick. Fascinating and entertaining keynote by John Hogenesch @jbhclock.bsky.social and on top of that, Steph Williams @williams-steph.bsky.social from the lab won first prize for her talk! @bioclocksuk.bsky.social #chronobiology
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htw @heniek-htw.bsky.social · 23/03/2025
Suprachiasmatic nucleus dysfunction may contribute to pathogenesis of anxiety and #depression via upregulation of the #BDNF -TrkB pathway in the striatum, potentially mediated by neural projections from the #SCN. Bmal1 gene within SCN may represent a novel therapeutic target for #mood disorders.
https://www.nature.com/articles/s41398-025-03313-7
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Journal of Cell Science @jcellsci.bsky.social · 21/03/2025
In our interview with Jennifer Lippincott-Schwartz, we discuss her research career, her advice on building collaborations and learn why she is looking forward to #biologists100. Jennifer will be speaking in our emerging technologies session. journals.biologists.com/jcs/article/...
Jennifer Lippincott-Schwartz
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mattiaquattro.bsky.social @mattiaquattro.bsky.social · 21/03/2025
www.sciencedirect.com/science/arti... new review by Bala Koritala and colleagues on the circadian biology of sleep apnea and cardiovascular consequences is out on JMCC in our special issue on circadian biology, check it out!
sciencedirect.com
Circadian Biology in Obstructive Sleep Apnea-Associated Cardiovascular Disease
A dysregulated circadian system is independently associated with both Obstructive Sleep Apnea (OSA) and cardiovascular disease (CVD). OSA and CVD coex…
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Shannon Macauley @macauleylab.bsky.social · 20/03/2025
The importance of considering time of day for metabolic experiments www.nature.com/articles/s42...
nature.com
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism
This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...
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Naomi Mittet @naolimit.bsky.social · 19/03/2025
“...problems arise when an early bird must stay up until 11 p.m. working late or a night owl has to wake up at 6 a.m. to take the kids to school,” Pendergast said. www.newswise.com/articles/jul...
newswise.com
Julie Pendergast Uncovers Hidden Health Effects of Disrupted Sleep, Circadian Rhythms | Newswise
The University of Kentucky’s Julie Pendergast, Ph.D., and a team of researchers are exploring how disruptions to our body’s natural circadian rhythms and sleep impact health.“Overwhelming evidence sug...
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Oksana Iamshanova @iamshanovao.bsky.social · 18/03/2025
Next Tuesday, Dr. Goragot Wisedchaisri will share his insights into the relationship between the structure of #volatgegatedsodiumchannel Nav1.7 and its role in #pain ⚛️ Please pay attention to the time schedule depending on your area: 🌍10 am (EDT)/ exceptionally at 3pm (CET) lnkd.in/eqvVXEsW
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Karyn @kaesser.bsky.social · 17/03/2025
Studying metabolism? Pay attention to time of day Nice collaborative review led by Satchin Panda www.nature.com/articles/s42...
nature.com
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism
This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...
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brian_delisle @bpdelisle.bsky.social · 16/03/2025
🚨🆕🫁 🔬 Fan et al reveal how ECM remodeling shapes ARDS progression- Collagen III, IV & lumican 📉 drop as damage worsens, while fibronectin & total collagen surge 📈 in late stage👉 journals.physiology.org/doi/abs/10.1... #ARDS #Pulmonary #Physiology #Science 🧪
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