Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.

Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological functions. They reveal cancer/disease-specific functions of FoxP1 in the disruption and reprograming of the skeletal-muscle circadian transcriptome, which may contribute to cancer-induced muscle loss.

Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological functions. They reveal cance...

Ablation of SC-Bmal1 lowered force production and altered the magnitude of muscle damage/repair and SC myogenic progression following eccentric contractile injury.