l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...

This study shows that optimally sized nanocarriers reach Duchenne muscular dystrophy muscle primarily through transcytosis, where they can deliver tamoxifen to improve muscle health and strength in mi...

Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations s...

The study shows that DNA double-strand break repair follows a circadian rhythm: homologous recombination peaks in the morning and declines by evening. CRY1 regulates CCAR2 to modulate this cycle, link...

The drug is cheap and already used during surgery. The clinical study will look at whether taking it for seven days afterward could speed up recovery times in teenaged patients.

Introduction Myostatin (MSTN), a transforming growth factor-beta (TGF-β) superfamily member, is an evolutionarily conserved negative regulator of skeletal muscle mass. Loss of MSTN commonly promotes...

Background Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogen...

Statins lower blood plasma cholesterol but can cause muscle-related issues including life-threatening rhabdomyolysis. Here the authors show that atorvastatin binds as triplets to the skeletal muscle R...

Hackers are ramping up attacks on academic institutions to access valuable data and to demand ransoms.

Studies related to HIV and other infectious diseases will be phased out, sources say; fate of the agency's animals remains unclear

Scientific Reports - Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice

In mdx mouse fetuses, the lack of dystrophin markedly impairs secondary myogenesis due to reduced muscle stem cell polarity. AAK1 deletion restores polarity and rescues secondary myogenesis, revealing...

Meng et al. develop the adeno-associated virus 9-based therapy CM-YAPon to transiently and inducibly express YAP in the heart. In mice, CM-YAPon promoted cardiomyocyte cell cycle reentry and reprogram...

Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in mice.

Based on an acute exercise model, Yan et al. identify lactate as a positive regulator of autophagy in skeletal muscle. Lactate triggers muscle autophagy via K921 lactylation-dependent inactivation of ...

The Advanced Cardiac Therapies Improving Outcomes Network formed a dystrophinopathy registry to define cardiac diagnostics, management, and advanced t…

Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.

Defective neurotransmission is a hallmark of spinal muscular atrophy (SMA). Here, the authors show that local presynaptic Munc13-1synthesis is defective in SMA and that modification of the Munc13-1 mR...

Skeletal muscle consists in a bundle of thousands post-mitotic multinucleated cells, called myofibers, in which myonuclei are evenly spaced and positioned at the periphery. This myonuclear positioning...

Nabarun Dasgupta was recognized with a MacArthur "genius" award for work studying the deadly overdose crisis. He's also a front-line organizer, helping people survive.

A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down.

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

Those who cite scientific studies to support policies should take care to tell the whole story, especially when it’s complex.

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Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

While low-dose adeno-associated virus (AAV) gene therapy has been generally well tolerated, multiple recent reports have documented fatalities associated with high-dose AAV vectors. These events have ...

Circadian rhythm is critical in maintaining metabolic homeostasis, including cardiac health, with disruptions often leading to adverse cardiac outcomes. Time-restricted feeding/eating (TRF/TRE) is a d...

This review tracks the discovery of circadian biology in cardiovascular science, starting with early clinical observations of daily changes in heart rate, blood pressure, and cardiovascular events. Th...

Circadian rhythms are an endogenous timekeeping system with a period of approximately 24 h that regulate many aspects of body physiology to maintain organismal health. Dysregulation of circadian rhyth...

I was fired after 29 days because I held the line and insisted on rigorous scientific review.

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Development of LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution at any defined subcellular location under p...