Stem cells have reshaped modern biology. At Yale School of Medicine, researchers are uncovering how they function and how to harness them for human health.

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Recent studies have uncovered that the calvarial bone marrow (BM), located within the skull, functions as a specialized hematopoietic niche distinct from BM in long bones. This compartment supports a ...

Hiring: PostDoc in Tissue Clearing & 3D Histopathology 🧪🖥️ My lab at Helmholtz Munich is seeking a highly motivated PostDoc/Scientist to strengthen our efforts in advanced imaging of cancer tissues. ...

Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary ...

The revised classification will help ensure different giraffe populations are adequately protected, conservationists say

Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

Meningeal mast cells, via the receptor Mrgprb2/X2, orchestrate brain inflammation after stroke by recruiting and promoting the transfer of skull bone marrow neutrophils into the brain, highlighting these mast cells as key regulators of brain immunity and of the skull bone marrow-meningeal-brain network.

Challen and colleagues show that the clonal expansion of Dnmt3a-null HSCs in serial bone marrow transplantation assays is not dependent on the loss of DNA methylation functions of Dnmt3a. They identify non-canonical functions for Dnmt3a in the regulation of telomere length and genome stability that restrict the functional potential of HSCs.

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Xing et al. construct a comprehensive pan-cancer human brain metastasis (BrM) atlas at single-cell resolution, uncovering five major BrM ecotypes associated with distinct phenotypic characteristics. The study also identifies several novel cell states and subsets that are strongly enriched in BrM across different lineages, suggesting them as potential therapeutic targets for future investigations.

Nature - High-resolution imaging method could lead to wiring diagram for the whole body.

Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...

New discovery confirms the long-debated hypothesis that the ancient winged reptiles ate plants

Germany digs reveal a large-scale operation 100,000 years earlier than oldest known fat rendering by modern humans.

A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promises to be a versatile brainsmatics tool for studying the whole brain at single-cell level.

New director Rui Benedito brings advanced genetic tools to study how mutations affect single cells and contribute to cardiovascular disease or cancer.