Ambjørn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using base-editing screens, identifying 450 reported and 264 predicte...

A widely used tyrosine phosphatase inhibitor also oxidizes and activates the tyrosine kinase SRC.

Cells depend on early protein modifications for proper function. Here, the authors show that when Src-family signaling kinases lack their typical myristoylation, an alternative acetylated start is det...

Enzymes are central to life, with their catalytic activity often shaped by the dynamic conformations of regulatory loops. In hub enzymes such as tyrosine kinases, the activation loop critically contro...

Comprehensive characterization of mutational effects in the human phosphatase SHP2 reveals mechanisms of intra- and inter-domain regulation, shedding light on the mechanisms of pathogenicity for hundr...

Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...

Intrinsically disordered regions (IDRs) in proteins play essential roles in cellular function. A growing body of work has shown that IDRs often interact with partners in a manner that does not depend ...

Phosphorylation forms an important part of the signalling system that cells use for decision making and regulation of processes such as cell division …

A symposium marking the contributions of Len Stephens and Phillip Hawkins

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Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.

AbstractSummary. The inference of kinase activity from phosphoproteomics data can point to causal mechanisms driving signalling processes and potential dru