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Barzin Nabet

@barzin-nabet.bsky.social
342 followers 791 following 10 posts

Here for Sixers and science. Sr Principal Scientist at Genentech focused on lung cancers.

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Reposted by Barzin Nabet
Princess Vimentin PhD | Cancer Biologist @princess-vimentin.bsky.social · 14/08/2026
From the administration that likes to tout "transparency". Usually, the research team that writes the #NIH grant sees funding scores (percentiles, impact scores) from the reviewers. Now, this won't be available. Why? The only reason: political meddling. 🧪 grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-088: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH
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Erin Grugan @eringrugan.bsky.social · 24/07/2026
Lebron James posted his Sixers announcement video to IG... it's set to Meek Mill's Dreams and Nightmares 😤
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Elizabeth McKenna @elizsmckenna.bsky.social · 23/06/2026
Now in Cancer Discovery @aacrjournals.bsky.social: Deconvolving SARS-CoV-2 mRNA Vaccine Impact on Immunotherapy-related Survival - by Justin Jee, @sawyerslabmskcc.bsky.social, Nikolaus Schultz, et al. doi.org/10.1158/2159... @mskcancercenter.bsky.social
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CJ Fogler @cjzero.bsky.social · 30/04/2026
Great angle of Cam York's goal. Love the Dan Vladar reaction
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Bradford Pearson @bradfordpearson.bsky.social · 29/01/2026
“Without Dan’s voice, Philly Mag wouldn’t be Philly Mag. And, I’d argue, Philadelphia wouldn’t quite be Philadelphia.” Dan’s editor here, Brian Howard, on what our friend meant to this magazine and, more importantly, this city.
phillymag.com
Dan McQuade Got Philly Like No One Else
The writer, who died Wednesday, was one of the most gifted chroniclers of the Philadelphia experience.
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treb @treblaw.bsky.social · 29/01/2026
start your day with a smile and a laugh. "The international news media" still gets me every time
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Kelsey McKinney @mckinneykelsey.bsky.social · 29/01/2026
king of the bloggers. king of philadelphia
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Bradford Pearson @bradfordpearson.bsky.social · 29/01/2026
Dan McQuade was the lifeblood of Philly writers, a mensch whose gift for writing was only surpassed by his love of his country, Philadelphia. The city will never be the same without him.
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David_j_roth @davidjroth.bsky.social · 29/01/2026
Rest in peace to one of the great bloggers and the de facto mayor of Philadelphia. It was my honor and pleasure to work with him. defector.com/dan-mcquade-...
defector.com
Dan McQuade, 1983–2026 | Defector
Dan McQuade, our friend and colleague, died this week at the age of 43. He is survived by his wife and young son. At the end of 2024, Dan was diagnosed with neuroendocrine cancer. The news of his diag...
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Jeff Rueter @jeffrueter.bsky.social · 25/01/2026
Kare 11 local news just read, in full, this statement from Michael and Susan Pretti, the parents of Alex Pretti. "Please get the truth out about our son."
Statement from Michael and Susan Pretti
Parents of Alex Jeffrey Pretti

“We are heartbroken but also very angry.

Alex was a kindhearted soul who cared deeply for his family and friends and also the American veterans whom he cared for as an ICU nurse at the Minneapolis VA hospital. Alex wanted to make a difference in this world. Unfortunately, he will not be with us to see his impact.

I do not throw around the ‘hero’ term lightly. However, his last thought and act was to protect a woman. The sickening lies told about our son by the administration are reprehensible and disgusting. Alex is clearly not holding a gun when attacked by Trump’s murdering and cowardly ICE thugs. He had his phone in his right hand and his empty left hand is raised above his head while trying to protect the woman ICE just pushed down, all while being pepper sprayed. 

Please get the truth out about our son. He was a good man. Thank you.
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Defector @defector.com · 12/01/2026
The sports highlight of the day is this ICE goon eating shit: defector.com/the-sports-h...
defector.com
The Sports Highlight Of The Day Is This ICE Goon Eating Shit | Defector
Federal agents continued their operations in Minneapolis over the weekend, where they were met with resistance from local residents who do not want to see their communities invaded by masked…
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Derek Bodner @derekbodner.bsky.social · 20/12/2025
Sixers vs Knicks box at the half.
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Barzin Nabet @barzin-nabet.bsky.social · 12/12/2025
great new SCLC review, captures the nuance of tumor/TME states well: www.cell.com/trends/cance...
cell.com
Small-cell lung cancer: anatomy of an immune-cold tumor
Small-cell lung cancer (SCLC) is an aggressive neuroendocrine (NE) tumor and a leading cause of cancer-related morbidity. The introduction of immune checkpoint inhibitors (ICIs) transformed the treatm...
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Miriam B. Goodman, PhD @wormsense.bsky.social · 27/10/2025
Molecular & Cellular Physiology (MCP) Monday We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n facultypositions.stanford.edu/en-us/job/49...
facultypositions.stanford.edu
Stanford | Faculty Positions: Details - Assistant Professor of Molecular and Cellular Physiology
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Trudy G. Oliver @tgoliver.bsky.social · 17/09/2025
Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer. rdcu.be/eGUtj
rdcu.be
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...
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CJ Fogler @cjzero.bsky.social · 31/08/2025
Spectacular from Szoboszlai
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Carl T. Bergstrom @carlbergstrom.com · 08/08/2025
1. Federal funding for research promotes tech, biomedical, and scientific discovery in the US, and provides training for the sci/tech workforce that has brought immeasurable wealth to the US over the past 75 years. Today's executive order includes a provision that will obliterate both functions.
whitehouse.gov
Improving Oversight of Federal Grantmaking
By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal
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W.E.D.em Boyz @leftistwonk.bsky.social · 06/08/2025
Even hundreds of trucks would not be enough "There are an increasing number of children that need to be in the hospital because they can’t eat food. They have got to that stage of severe acute malnutrition where their bodies just can’t digest food. And so those kids need to be in intensive care."
newyorker.com
How to Prevent More Starvation Deaths in Gaza
As Israel refuses to let in sufficient humanitarian aid, a leading expert on famine explains why even “flooding the zone” with food won’t be enough.
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John Foley @2008philz.bsky.social · 05/08/2025
Harrison Bader looks like all of the 1993 Phillies had a baby together
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John Foley @2008philz.bsky.social · 02/08/2025
Jhoan Duran intro at Citizens Bank Park
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frank @fgif.bsky.social · 30/07/2025
That Duran entrance is going to be wild at CBP, grab me a $17 yuengling and let’s ride
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Liz Essley Whyte @lizessleywhyte.bsky.social · 30/07/2025
NEW The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year Chokes off billions in research funding Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social
wsj.com
Trump Administration Puts New Chokehold on Billions in Health-Research Funding
The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.
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Daniel Mucida @danmucida.bsky.social · 24/07/2025
Heartless murderers. www.nytimes.com/2025/07/24/w...
nytimes.com
Gazans Are Dying of Starvation
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Nick Piccone @piccone.bsky.social · 16/07/2025
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United Farm Workers @ufw.bsky.social · 13/07/2025
Our hearts are heavy for the grieving family of Jaime Alanis, who died from injuries sustained during a chaotic raid on Thursday. We will do everything we can to support them. We continue to work with the hundreds of farm worker families navigating the aftermath of this violent raid.
photo of Jaime Alanis
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Barzin Nabet @barzin-nabet.bsky.social · 02/07/2025
www.thelancet.com/journals/lan...
thelancet.com
Evaluating the impact of two decades of USAID interventions and projecting the effects of defunding on mortality up to 2030: a retrospective impact evaluation and forecasting analysis
USAID funding has significantly contributed to the reduction in adult and child mortality across low-income and middle-income countries over the past two decades. Our estimates show that, unless the a...
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Waggoner Lab @labwaggoner.bsky.social · 30/06/2025
Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity @cp-immunity.bsky.social www.cell.com/immunity/ful...
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The Associated Press @apnews.com · 24/06/2025
BREAKING: Palestinian witnesses and hospitals say Israeli forces opened fire toward hundreds of people waiting for aid trucks in central Gaza, killing at least 25 people.
bit.ly
Israeli forces fire on people waiting for aid in Gaza, killing 25, witnesses and hospitals say
Palestinian witnesses say Israeli forces and drones opened fire toward hundreds of people waiting for aid trucks in central Gaza.
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Ben Collins @bencollins.bsky.social · 22/06/2025
theonion.com/this-war-wil...
theonion.com
This War Will Destabilize The Entire Mideast Region And Set Off A Global Shockwave Of Anti-Americanism vs. No It Won’t
George W. Bush may think that a war against Iraq is the solution to our problems, but the reality is, it will only serve to create far more.
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Musa Okwonga @okwonga.bsky.social · 01/06/2025
“More than 30 Palestinians were killed by Israeli fire on Sunday as they went to receive food at an aid distribution point set up by an Israeli-backed foundation in Gaza, according to witnesses, with a hospital run by the Red Cross confirming it was treating many wounded.”
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charlesrudin.bsky.social @charlesrudin.bsky.social · 26/05/2025
First Bluesky post… New paper out, following on FOXA observations of the @juliensage.bsky.social lab; nice collaboration with the @joanmassague.bsky.social lab led by a shared post-doc, Kenta Kawasaki www.nature.com/articles/s41...
nature.com
FOXA2 promotes metastatic competence in small cell lung cancer - Nature Communications
Small cell lung cancer presents high and multi-site metastatic potential. Here, the authors discover that FOXA2, regulated by ASCL1, promotes multi-site metastasis in small cell lung cancer by inducin...
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Max Kozlov @maxkozlov.bsky.social · 21/05/2025
Who's calling the shots at NIH? Sworn testimonies and internal e-mails reveal for the first time the breadth of DOGE's control over the world's largest public biomedical funder. DOGE has provided lists of hundreds of grants to cut, and DOGE is now reviewing ALL NIH awards before they're released
nature.com
NIH killed grants on orders from Elon Musk’s DOGE
Court documents and internal correspondence show the cost-cutting force has broad control over the world’s largest public biomedical funder.
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Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · 15/05/2025
We're excited to share that Dr. Andy Minn will return to Memorial Sloan Kettering Cancer Center (MSK) as the inaugural Chair of MSK’s new Immuno-Oncology Program in August. Learn more about Dr. Minn: bit.ly/44Advyo
bit.ly
Andy Minn, MD, PhD, will rejoin Memorial Sloan Kettering Cancer Center as the Inaugural Chair of MSK’s new Immuno-Oncology Program
Andy Minn, MD, PhD, will return to Memorial Sloan Kettering Cancer Center (MSK) as the inaugural Chair of MSK’s new Immuno-Oncology Program in August.
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Julia Carrie Wong @joolia.bsky.social · 08/05/2025
“States must act now to end the violence or bear witness to the annihilation of the Palestinian population in Gaza – an outcome with irreversible consequences for our shared humanity”
ohchr.org
End unfolding genocide or watch it end life in Gaza: UN experts say States face defining choice
GENEVA – Escalating atrocities in Gaza present an urgent moral crossroads and States must act now to end the violence or bear witness to the annihilation of the Palestinian population in Gaza – an out...
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Barzin Nabet @barzin-nabet.bsky.social · 29/04/2025
Awesome work as usual from @davidmacphersonlab.bsky.social , wonderful to play a small part!
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Lorena O’Neil @lorenaoneil.com · 26/04/2025
BREAKING: @aclu.org says Trump deported a child (U.S. citizen) with metastatic cancer without medication or consultation with physicians. This is the second child with cancer he's deported. www.rollingstone.com/politics/pol... @rollingstone.com
rollingstone.com
Trump Has Now Deported Multiple U.S. Citizen Children With Cancer
Two families who had lived in the United States for years, including a child with cancer and a pregnant mother, were deported by ICE on Friday.
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Kyle Cheney @kyledcheney.bsky.social · 26/04/2025
NEW: A federal judge raised alarm Friday that the Trump administration appeared to have deported a 2-year-old U.S. citizen to Honduras with "no meaningful process" — even as her father was fighting to keep her in the country. Details w/ @joshgerstein.bsky.social www.politico.com/news/2025/04...
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Edward Nirenberg @enirenberg.bsky.social · 23/04/2025
I don't get how anyone can possibly be okay with ending the WHI. This study has accrued decades of data from 42000 women and it is still going. It helps to address critical research gaps that have been allowed to go unfilled because of durable misogyny and provides invaluable insight into aging.
science.org
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
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Barred and Boujee aka Madiba Dennie @audrelawdamercy.blacksky.app · 18/04/2025
fighting tears
a screenshot of the first several paragraphs of the quote-skeeted article, with the following paragraphs highlighted in yellow:

“If I die, I want a loud death,” Hassouna wrote on social media. “I don’t want to be just breaking news, or a number in a group, I want a death that the world will hear, an impact that will remain through time, and a timeless image that cannot be buried by time or place.”

On Wednesday, just days before her wedding, 25-year-old Hassouna was killed in an Israeli airstrike that hit her home in northern Gaza. Ten members of her family, including her pregnant sister, were also killed.

The Israeli military said it had been a targeted strike on a Hamas member involved in attacks on Israeli soldiers and civilians.
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Edward Nirenberg @enirenberg.bsky.social · 29/03/2025
Peter Marks’s resignation letter. Everyone should read this.
Peter Marks, MD, PhD
Director, Center for Biologics Evaluation and Research U.S. Food and Drug Administration
10903 New Hampshire Avenue
Silver Spring, MD 20903
March 28, 2025
Sara Brenner, MD, MPH
Acting Commissioner of Food and Drugs
U.S. Food and Drug Administration
10903 New Hampshire Avenue
Silver Spring, MD 20903
Dear Dr. Brenner:
It is with a heavy heart that I have decided to resign from FDA and retire from federal service as Director of the Center for Biologics Evaluation and Research effective April 5, 2025. I leave behind a staff of professionals who are undoubtedly the most devoted to protecting and promoting the public health of any group of people that I have encountered during my four decades working in the public and private sectors. I have always done my best to advocate for their well-being and I would ask that you do the same during this very difficult time during which their critical importance to the safety and security of our nation may be underappreciated.
Over the past years I have been involved in enhancing the safety of our nation's blood supply, in advancing the field of cell and gene therapy, and in responding to public health emergencies. In the last of these, during the COVID-19 pandemic I had the privilege of watching the vision that I conceived for Operation Warp Speed in March 2020 in collaboration with Dr. Robert Kadlec become a reality under the leadership of HHS Secretary Azar and President Trump due to the unwavering commitment of public servants at FDA and elsewhere across the government. At FDA, the tireless efforts of staff across the agency resulted in remarkably expediting the development of vaccines against the virus, meeting the standards for quality, safety, and effectiveness expected by the American public. The vaccines undoubtedly markedly reduced morbidity and mortality from COVID-19 in the United States and elsewhere. Many of these same individuals applied learnings from the pandemic during a flawless response helping…ongoing multistate measles outbreak that is particularly severe in Texas reminds us of what happens when confidence in well-established science underlying public health and well-being is undermined.
Measles, which killed more than 100,000 unvaccinated children last year in Africa and Asia owing to pneumonitis and encephalitis caused by the virus, had been eliminated from our shores. The two-dose measles, mumps, rubella vaccine regimen (MMR) using over the past decades has a remarkably favorable benefit-risk profile. The MMR vaccine is 97% or more effective in preventing measles following the two-dose series, and its safety has been remarkably well studied. Though rarely followed by a single fever-related seizure, or very rarely by allergic reactions or blood clotting disorders, the vaccine very simply does not cause autism, nor is it associated with encephalitis or death. It does, however, protect against a potential devasting consequence of prior measles infection, subacute sclerosing panencephalitis (SSPE), which is an untreatable, relentlessly progressive neurologic disorder leading to death in about 1 in 10,000 individuals infected with measles. Undermining confidence in well-established vaccines that have met the high standards for quality, safety, and effectiveness that have been in place for decades at FDA is irresponsible, detrimental to public health, and a clear danger to our nation's health, safety. and security.
In the years following the pandemic, at the Center for Biologics Evaluation and Research we have applied the same unwavering commitment to public health priorities to the development of cell and gene therapies to address both hereditary and acquired rare diseases. During my tenure as Center Director we have approved 22 gene therapies, including the first gene therapy ever to be approved in the United States. However, we know that we must do better to expedite the development of treatments for those individual suffering from any one of the thousan…
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Trudy G. Oliver @tgoliver.bsky.social · 20/03/2025
#Squamous #lungcancer cells aren’t all alike — the tumor is a mix of distinct cancer cell states! @lukeizzo.bsky.social & Oliver lab uncover #KRT13+ hillock-like, slow-dividing, immunomodulatory tumor cells that resemble the recently discovered normal lung #hillock cells (Lin et al, Nature, 2024).
Schematic showing single cell RNA-seq from human squamous tumors, mouse models and tumor organoids. A second graphic shows a model of squamous lung cancer heterogeneity where KLF4 promotes basal cells to adopt a KRT13+ hillock-like state.
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Andrei Goga @andreigoga.bsky.social · 20/03/2025
UCSF, like all UC campuses, announced an immediate hiring freeze today. UCSF is the second largest employer in the city. There will be wide ripple effects in the Bay Area and beyond, including the future of biotech and pharma in the area. 🧪
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Soragni:Lab @alice.soragnilab.com · 18/03/2025
The NCI grant supporting the Columbia comprehensive cancer center was terminated. Tell me how terminating support for cancer research helps the economy. taggs.hhs.gov/Content/Data...
taggs.hhs.gov
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Ran Blekhman @blekhman.bsky.social · 19/03/2025
Chilling to see this list of terminated NIH grants. Research on Alzheimer's, HIV, rare diseases, vaccines -- gone. Cancer centers closed, training grants & fellowships terminated. Young scientists stranded. Patients waiting for treatments that'll never come. Just sad. taggs.hhs.gov/Content/Data...
taggs.hhs.gov
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Nick Kristof @nickkristof.bsky.social · 15/03/2025
Elon Musk says that no one has died because he slashed humanitarian aid. I went to South Sudan to check if that's true. It's not. Meet Peter, Achol and Evan, ages 10, 8 and 5. The reckless actions of the world's richest men are killing the world's poorest kids www.nytimes.com/interactive/...
nytimes.com
Opinion | Musk Said No One Has Died Since Aid Was Cut. That Isn’t True. (Gift Article)
A journey through the front lines of global poverty shows that when the world’s richest men slash aid for the world’s poorest children, the result is sickness, starvation and death.
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Atul Gawande @agawande.bsky.social · 13/03/2025
Nothing will kill more children than the ongoing decimation of CDC, NIH, and USAID work to lift vaccine uptake in the US and world. Child survival rose 75% in the last 50 years. Vaccines account for 40% of that. Measles vax alone was 60% of the benefit. www.thelancet.com/journals/lan...
thelancet.com
Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization
Since 1974 substantial gains in childhood survival have occurred in every global region. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50...
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Dave Levitan @davelevitan.bsky.social · 05/03/2025
Hannah Frank @hannaherf.bsky.social, a Cornell PhD candidate, gave a speech last week at a "Stand Up For Science" rally on campus about her mother who died of brain cancer. Here's what she said about Trump's featuring of a childhood brain cancer survivor at his rally last night:
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