New preprint from the Oliver Lab @tgoliver.bsky.social! We uncover a hillock-like cell state in squamous tumors using GEMMs, organoids, and human data while digging into the mechanisms that regulate cell state plasticity: KLF4 plays a crucial role! Check it out at: www.biorxiv.org/content/10.1...
biorxiv.org
KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer
Lung squamous cell carcinoma (LUSC) is basal-like subtype of lung cancer with limited treatment options. While prior studies have identified tumor-propagating cell states in squamous tumors, the broad...