Department Chemistry Vassar College is dedicated to providing equal employment opportunities to all applicants and employees and welcomes applications from individuals of all backgrounds. Decisions co...

Interactive qualitative molecular-orbital lessons for undergraduate chemistry.

Faculty have a responsibility to protect classrooms as a training ground for thinking, and proliferating LLMs endanger this core mission of the University.

Diarylamines are among the most privileged scaffolds in drug discovery, with a myriad of examples in the clinic including the multi-kinase inhibitor neratinib which possesses indications towards HER2 overexpressed breast cancers. Diarylamines possess a ...

The catalytic hydroboration of alkenes with pinacolborane (HBpin) represents a valuable yet challenging transformation in main-group catalysis, furnishing alkyl pinacol boronic esters of broad synthet...

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The emergence of affordable and reliable 3D printers has enabled laboratories to optimize setups, print custom parts, accelerate research, and rapidly prototype. A new movement has emerged in the past...

YouTube video by Center for Communicating Science at Virginia Tech

Fundamental properties including solubility and structure–reactivity correlations of potassium tert-butoxide (KOtBu) are described in this manuscript. A combination of donor solvent titration, diffusion NMR, and DFT studies established that KOtBu exists in one of three solution structures: (1) unsolvated cubic tetramer in non-Lewis basic solvents, (2) disolvated cubic tetramer in Lewis basic solvents, and (3) solvated monomer in protic solvents. These studies dispel the notion that strong aprotic donor solvents lead to deaggregation of KOtBu cubic tetramer. In DMSO, a concentration-dependent equilibrium mixture of bis-DMSO-solvated cubic tetramer, dimsylpotassium, and tert-butanol is formed. Donor solvent association with potassium was contextualized in terms of periodic trends within the alkali metal series. The previously reported 1:1 complex of KOtBu and tert-butanol was found to be highly insoluble and affords poor availability of KOtBu when employed in a model dehydrohalogenation reaction. Reactivity can be recovered by the inclusion of strongly Lewis basic donor solvents that disproportionately stabilize the transition state.

Solid-phase peptide chemistry is more than sixty years old. Its advent revolutionized peptide science. Innovation has increased safety and expanded the range of chemistries available to the practitioner, but the fundamental basis of the technology, the ...

Search for a Visiting Assistant Professor in Chemistry at Skidmore College. Learn about teaching, support, equity commitments, and how to apply.

Structural confirmation of an iodine(V) analogue of Weiss’s reagent, [ArI-O(Pyr)2]2+, is reported using monodentate pyridine ligands and a nitro-substituted arene to provide protection from electrophi...

Catalytic reactions involving multiple cycles are common in many key organic transformations. We report a detailed mechanistic analysis of one such network of “nested” cycles, the Ni-catalyzed cross-c...

Salophen ligands and their complexes with transition metals Cu(II), Fe(II), Fe(III), and Co(II) were synthesized and characterized by UV–vis, IR, and 1H NMR spectroscopy. The catalytic activity of the...

Nature - Myriad Aryne Derivatives from Carboxylic Acids

Chemical kinetics course Class 1: Historical introduction Class 2: 0-2nd order, equilibrium (analytical) Class 3: Reactions in series/parallel, Michaelis-Men...