Reposted by Arata WakimotoYours in negritude, Ryan K. Smith @mewefree.bsky.social · 10/10/2026Geese are insane: Example #2,987,304 39807233
Arata Wakimoto @arataw.bsky.social · 27/09/2026Stem Cell & Developmental Biology Early Career Symposium was one of the greatest event I've ever attended. Good scientific input, meeting new people, sharing excitement/failure. I am feeling so lucky that this was held at right across the street I walk everyday! 030
Arata Wakimoto @arataw.bsky.social · 25/09/2026One of the best moments in conferences is to meet someone who reached to the same problem independently🤝 000
Arata Wakimoto @arataw.bsky.social · 31/07/2026www.biorxiv.org/content/10.6... In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesis 😍 000
Reposted by Arata Wakimotothe Node @the-node.bsky.social · 19/06/2026The elephant in the room: impact factor 🐘 @jamesbriscoe.bsky.social and @amjeve.uk openly discuss their views on the impact factor and how the field of developmental biology is perceived through its lens. thenode.biologists.com/the-elephant... #DevBio #AcademicPublishing #ImpactFactorthenode.biologists.comThe elephant in the room: impact factor - the NodeAs new journal impact factors are released this week, it's worth considering what an impact factor really is and whether the academic community should put 022
Arata Wakimoto @arataw.bsky.social · 15/06/2026Xenophagocytosis blockade enhances interspecies chimerism: Cell www.cell.com/cell/fulltex... Great to see this on Cell!cell.comXenophagocytosis blockade enhances interspecies chimerismHost macrophages limit interspecies chimerism via xenophagocytosis, whereby stressed donor cells expose phosphatidylserine as an “eat-me” signal. Blocking xenophagocytosis successfully enhances donor ... 010
Reposted by Arata WakimotoCell - a Cell Press journal @cp-cell.bsky.social · 05/06/2026Now online! Xenophagocytosis blockade enhances interspecies chimerismdlvr.itXenophagocytosis blockade enhances interspecies chimerismHost macrophages limit interspecies chimerism via xenophagocytosis, whereby stressed donor cells expose phosphatidylserine as an “eat-me” signal. Blocking xenophagocytosis successfully enhances donor chimerism and enables efficient exogenic organogenesis. 011
Arata Wakimoto @arataw.bsky.social · 15/06/2026Opus4.8 keeps failing to call list_events from Gcal MCP since yesterday. Sonnet4.6, Opus4.6, Opus4.7 can call it. Weird! Might be related to the Fable's issue? 000
Arata Wakimoto @arataw.bsky.social · 13/05/2026This visual timer is by far the best buy of the year for my setup 100
Reposted by Arata WakimotoRiddhiman Garge @riddhiman.bsky.social · 25/04/20261/ Thrilled to share our latest: an exciting collaboration across the @jshendure.bsky.social, @leastarita.bsky.social, @nobuhamazaki.bsky.social and @dschweppe.bsky.social labs! 🧵 below- #SystemsBiology #SCBEM #MultiOmics #Gastruloids www.nature.com/articles/s41...nature.comThe proteomic landscape and temporal dynamics of human and mouse gastruloid development - Nature Cell BiologyGarge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development. 12411
Arata Wakimoto @arataw.bsky.social · 27/04/2026Happy to see our new paper on benchmarking RNA/protein dynamics in human and mouse gastruloids in Nature Cell Biology! 🎉 www.nature.com/articles/s41...nature.comThe proteomic landscape and temporal dynamics of human and mouse gastruloid development - Nature Cell BiologyGarge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development. 120
Arata Wakimoto @arataw.bsky.social · 31/03/2026Inhibition of MAFB and PI3K/AKT Signaling for Hereditary FSGS with Multicentric Carpotarsal Osteolysis : Journal of the American Society of Nephrology journals.lww.com/jasn/abstrac...journals.lww.com 000
Arata Wakimoto @arataw.bsky.social · 17/03/20260.33g mitigates muscle atrophy while 0.67g preserves muscle function and myofiber type composition in mice during spaceflight - goo.gl/scholar/MGaj1S Congrats for the team!!goo.gl 111
Reposted by Arata WakimotoBK. Titanji @boghuma.bsky.social · 25/01/2026William Foege has died. He was a central architect of smallpox eradication, pioneering surveillance-driven ring vaccination when vaccine supply was limited. That strategy helped eliminate the deadliest human pathogen we’ve ever known. www.nytimes.com/2026/01/24/u...nytimes.comWilliam H. Foege, Key Figure in the Eradication of Smallpox, Dies at 89 3331117
Reposted by Arata WakimotoNozomu Yachie @nzmyachie.bsky.social · 26/01/2026Please 🔁 My group at UBC received an allocation from the school to apply for the Canada Impact+ Training Awards (postdoc). Everything is moving fast but please email me in 48 hours with a CV if you are outside Canada and interested😎 Yachie lab: yachie-lab.org sshrc-crsh.canada.ca/en/funding/o...sshrc-crsh.canada.caCanada Impact+ Research Training AwardsThe Canada Impact+ Research Training Awards are a one-time initiative designed to recruit international or returning Canadian students and postdoctoral researchers to Canada. These awards support the recruitment of doctoral students and postdoctoral researchers in priority areas, helping build capacity, strengthen the research ecosystem and enhance Canada’s global competitiveness. 138
Arata Wakimoto @arataw.bsky.social · 26/01/2026It's my honor to be selected as one of the inaugural SeaBridge Fellows!👏 seabridge.uw.edu/2026/01/22/s...seabridge.uw.eduSeaBridge Selects Inaugural Cohort of Eight Fellows from UW and Fred Hutch - SeaBridgeThe first cohort of postdoctoral researchers has been selected for the SeaBridge Fellowship, a translational research training program affiliated with the Seattle Hub for Synthetic Biology (Seattle Hu... 120
Arata Wakimoto @arataw.bsky.social · 07/01/2026I never knew the title of the original BLAST paper was 'A Greedy Algorithm for Aligning DNA Sequences'. I just came across it and it's too cool!🤯 www.liebertpub.com/doi/10.1089/...liebertpub.com 110
Reposted by Arata WakimotoScience in Seattle @scienceinseattle.com · 07/01/2026The WRF has awarded three-year postdoctoral fellowships to a new cohort of 12 early-career researchers who will pursue innovative, high-impact projects. 📝 See the full list including Drs. Winston Dredge, Nastacia Goodwin, Stefany Cruz, and Nathaniel Ritz: bit.ly/3L0DhEM 011
Arata Wakimoto @arataw.bsky.social · 24/12/2025www.biorxiv.org/content/10.6... Extremely fine tuned. genuinely admiring!biorxiv.orgHuman trunk embryoids with patterned anterior-posterior and dorsal-ventral body axes: utility for understanding human development and diseaseHuman embryoid models enable mechanistic studies of development and disease. We generated trunk embryoids from human pluripotent stem cells that recapitulate posterior trunk formation at Carnegie stag... 110
Reposted by Arata WakimotoNaomi Moris @nmoris.bsky.social · 16/12/2025Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...nature.comModelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell BiologyMakwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk. 58933
Reposted by Arata Wakimotoderek van vliet @derek.bike · 25/11/2025when we say we want more streets to be pedestrianized, this is what we mean 663315896
Reposted by Arata Wakimotoallen institute @alleninstitute.org · 20/10/2025Congratulations to Karel Svoboda and @jshendure.bsky.social on their election to the National Academy of Medicine (@nam.edu)! Election to the Academy is one of the highest honors in health and medicine. #NAMmtg More on their journeys to this achievement: alleninstitute.org/news/karel-s...alleninstitute.orgKarel Svoboda and Jay Shendure elected to National Academy of MedicineThe honor recognizes leaders who have demonstrated outstanding achievement and made lasting contributions to the advancement of the medical sciences, health care, and public health 15010
Arata Wakimoto @arataw.bsky.social · 17/10/2025www.biorxiv.org/content/10.1... Simplified In Vitro Generation of Human Gastruloids for Modelling Early Developmentbiorxiv.orgSimplified In Vitro Generation of Human Gastruloids for Modelling Early DevelopmentThe purpose of this study was to optimize the efficiency and cost of human gastruloid formation by testing and adjusting individual parameters using as examples two distinct human pluripotent stem cel... 020
Arata Wakimoto @arataw.bsky.social · 15/10/2025Plasmidsaurus's 50$ RNA-seq is just amazing. I won't do qPCRs anymore 0132
Reposted by Arata Wakimotoplasmidsaurus @plasmidsaurus.bsky.social · 15/10/2025🦖 Something HUGE just hatched. Plasmidsaurus now offers RNA sequencing for gene expression analysis: • As fast as 3 day turnaround • $50/sample for academia, $80 for industry • Up to ~10M unique transcript 3’ end reads per sample • Interactive results Explore Plasmidsaurus RNA-Seq today. 49336
Arata Wakimoto @arataw.bsky.social · 06/10/2025Happy Mid-Autumn Festival!!🥮🎑🌕 I love mooncakes so much 100
Reposted by Arata WakimotoSimon Fisher @profsimonfisher.bsky.social · 04/10/2025Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350.... A personal thread about the ups & downs of the journey we took to get to that point....1/n 🗣️🧬🧪 49236
Reposted by Arata WakimotoRaquel Fueyo @fueyoraquel.bsky.social · 01/10/2025Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tDrdcu.beA human-specific regulatory mechanism revealed in a pre-implantation modelNature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development. 1114051
Arata Wakimoto @arataw.bsky.social · 02/10/2025www.nature.com/articles/s41... Cool paper! Very happy to see my friend's name on itnature.comA human-specific regulatory mechanism revealed in a pre-implantation model - NatureGenetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development. 010
Reposted by Arata WakimotoNobu Hamazaki @nobuhamazaki.bsky.social · 26/09/2025New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1... 35420
Arata Wakimoto @arataw.bsky.social · 09/09/2025Thinking about interspecies differences is always fun. Glad to see this story from my previous lab is out! 000
Arata Wakimoto @arataw.bsky.social · 08/09/2025Sadaki, S., Tsuji, R., Hayashi, T. et al. Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle. Skeletal Muscle 15, 19 (2025). doi.org/10.1186/s133...doi.orgLarge MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle - Skeletal MuscleBackground Small mammals such as mice rely on type IIb myofibers, which express the fast-contracting myosin heavy chain isoform Myh4, to achieve rapid movements. In contrast, larger mammals, including... 010
Arata Wakimoto @arataw.bsky.social · 29/08/2025Are there any reagents/technique available to quench fluorescent proteins (like mCitrin)? My cell line has a few fluorescent reporters so that they use up channels and I cant stain multiple targets. Appearently they are still very bright after 4% PFA fixation. 000
Arata Wakimoto @arataw.bsky.social · 20/08/2025The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation bioRxiv 2025.06.24.661270; doi: doi.org/10.1101/2025...doi.orgThe generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferationThe generation of human organs in animals through blastocyst complementation offers a promising solution to the shortage of transplantable organs. While human pluripotent stem cells (hPSCs) can contri... 100
Reposted by Arata WakimotoSociety for Developmental Biology @socdevbio.bsky.social · 18/08/2025🐟 Zebrafish (Danio rerio): Clear as glass, zebrafish embryos let you watch organs form in real time. A powerhouse for studying organogenesis and regeneration, they’re also champions of transgenic expression of fluorescent proteins 🌈 image from Gopi Shah 🧪 #ModelMonday #DevBio 07525
Arata Wakimoto @arataw.bsky.social · 01/08/2025Gemini's Gcal integration is not reliable at all... It cant hook up schedules from multiple calendars 000
Arata Wakimoto @arataw.bsky.social · 17/07/2025Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development www.nature.com/articles/s41... "Bats are the only mammals capable of self-powered flight" so coolnature.comComparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & EvolutionSingle-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ... 010
Reposted by Arata WakimotoAxel Visel @axelvisel.bsky.social · 16/07/2025No new genes needed to fly - just rewire what you have! 🦇🧬 Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social doi.org/10.1038/s415... #EvoDevo #SingleCell #BatWingsdoi.orgComparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & EvolutionSingle-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ... 311743
Arata Wakimoto @arataw.bsky.social · 07/07/2025Apparently if you write down 300 random numbers, researchers can identify you with 96.5% accuracy. Cool. www.nature.com/articles/s41...nature.comA cognitive fingerprint in human random number generation - Scientific ReportsScientific Reports - A cognitive fingerprint in human random number generation 000
Arata Wakimoto @arataw.bsky.social · 07/07/2025Most AI tools for research help me find more papers to read but... what I recently need is AI that helps me read fewer papers. Drowning in literature, I need it to suggest to me which 8 of my current 50 papers I can safely skip. 010
Arata Wakimoto @arataw.bsky.social · 02/07/2025This week marks a year since I moved to Seattle! 🏔️ 🌊🏙️ Pivoting from mouse embryo work to a human embryo model, while moving to a new country, has been a real challenge. But I feel more equipped now - looking forward to what year two brings! 110
Arata Wakimoto @arataw.bsky.social · 28/06/2025Japan's SPRING fellowship shouldn't exclude international PhD students. Diverse research teams create better learning opportunities. Please don't let nationalism divide science. www.change.org/p/%E5%8D%9A%...change.orgあなたの声がチカラになります博士課程の学生を国籍で差別しないでください! ― SPRING制度「日本人限定」見直し方針に反対します ― 100
Arata Wakimoto @arataw.bsky.social · 05/06/2025Many papers from Osaka U have caught my eye recently. Genuinely admire them 000
Arata Wakimoto @arataw.bsky.social · 05/06/2025Exciting title👀😮 Maternal iron deficiency causes male-to-female sex reversal in mouse embryos www.nature.com/articles/s41...nature.comMaternal iron deficiency causes male-to-female sex reversal in mouse embryos - NatureIron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice. 100
Arata Wakimoto @arataw.bsky.social · 04/06/2025This beautiful video just came across to me - just like the sun☀️ www.hhmi.org/beautifulbio... 010
Arata Wakimoto @arataw.bsky.social · 03/06/2025Good news for Coffee lovers www.nature.com/articles/s41...nature.comCoffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts - Nature MicrobiologyCoffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome. 000
Arata Wakimoto @arataw.bsky.social · 27/05/2025Just gave a 1-hour+ presentation. Every time I give a talk, I realize I enjoy speaking about what I've learned in front of people. probably more than doing experiments. Like I do experiments to get topics to talk about next time. Does anyone have a similar feeling? 000