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Todd Douglas

@apoptoddic.bsky.social
569 followers 342 following 25 posts

• scientific associate studying why & how cells die • princess margaret cancer centre • he/him orcid.org/0000-0002-6053-9345

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Todd Douglas @apoptoddic.bsky.social · 30/08/2026
I've been thinking about this comic all week.
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Jamie Cate @jhdcate.bsky.social · 27/08/2026
Ribosomes have a strange protein modification in a universally-conserved protein uS11. This modification, isoaspartate, is also conserved in nearly all forms of life. We originally found this modification using cryo-EM, but had no idea how it was formed. 1/ elifesciences.org/articles/60482
elifesciences.org
Structure of the bacterial ribosome at 2 Å resolution
High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and ref...
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Jonathan Pruneda @jnpruneda.bsky.social · 22/08/2026
WE'RE HIRING! Thanks to some recent successes with NIH funding, we're seeking two new postdoctoral scholars to join our team. See below for details. Please share widely and feel free to reach out with any questions!
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Katharine Hayhoe @katharinehayhoe.com · 15/07/2026
830 wildfires burning across Canada right now. And you know what’s going to make it worse in the future? More oil pipelines. This is why our voice and our vote matters.
A NASA map of the wildfires burning across Canada right now.
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Todd Douglas @apoptoddic.bsky.social · 11/07/2026
Thanks to Boyi Gan's group (@mdanderson.bsky.social) for this nice summary and contextualization of our (@craigmcrews.bsky.social) recent paper! Still lots more to understand... www.nature.com/articles/s41...
nature.com
Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation - Cell Death & Differentiation
Cell Death & Differentiation - Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation
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Todd Douglas @apoptoddic.bsky.social · 11/07/2026
Thanks to Boyi Gan's group (@mdanderson.bsky.social) for this nice summary and contextualization of our (@craigmcrews.bsky.social) recent paper! Still lots more to understand... www.nature.com/articles/s41...
nature.com
Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation - Cell Death & Differentiation
Cell Death & Differentiation - Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation
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Avi Lewis @avilewis.ca · 03/07/2026
Add your name to tell Prime Minister Carney to protect our future over Big Oil profits: www.ourcommons.ca/petitions/en...
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Avi Lewis @avilewis.ca · 03/07/2026
Today’s announcement shows what this federal government will protect above all else: the profits of Big Oil. Read my full statement on the oil pipeline proposal from the Prime Minister and Premier Smith: www.ndp.ca/news/ndp-rea...
ndp.ca
NDP Reaction to West Coast Pipeline Announcement
NDP Leader Avi Lewis shared the following statement in response to the oil pipeline proposal from Alberta Premier Danielle Smith:
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Greg Sargent @gregsargent.bsky.social · 17/06/2026
Elon Musk's incitement of pogroms in Belfast reveals he'll use his immense wealth and influence to foment untold fascist violence in the future. Only a global movement can break his power. New piece from @polphilpod.bsky.social and me. Threading highlights below. 1/ newrepublic.com/article/2119...
newrepublic.com
Elon Musk’s Race War Just Took Darker Turn—Time for a Global Response
The violent fascist riots in Belfast reveal the future that the trillionaire really wants. We need an international movement to constrain him.
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Todd Douglas @apoptoddic.bsky.social · 11/06/2026
Congrats Diego!!
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Colette Delawalla, PhD @cdelawalla.bsky.social · 06/06/2026
I NEED YOUR ATTENTION. When violent and controlling people start to feel their power slip, they become more violent and controlling. I believe this is what’s happening in the Administration, now. This is a CRITICAL INFLECTION POINT: we MUST come together and push back *hard* NOW. 🧵 a thread
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American Society for Cell Biology @ascbiology.bsky.social · 04/06/2026
Scientists: Your voice is needed. New federal regulations could reshape research funding, publishing, and collaboration. Comments close July 13. www.ascb.org/science-policy/propose…
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Colette Delawalla, PhD @cdelawalla.bsky.social · 04/06/2026
Listen, the @standupforscience.net national team is working all hours of the day to stop Vought, RFK Jr., and Trump et al., from destroying our scientific ecosystem. We are fueled by small donors--plz chip in if you are able. If you're a big donor PLZ SUPPORT US! www.standupforscience.net/donate
standupforscience.net
Fuel the fight! — STAND UP FOR SCIENCE
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Todd Douglas @apoptoddic.bsky.social · 30/05/2026
Thanks so much Cristina! Just for the record, using "disulfidptosis" was a reviewer request.. 🫣
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Todd Douglas @apoptoddic.bsky.social · 28/05/2026
Thanks for sharing!
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Nature Cell Biology @natcellbio.nature.com · 25/05/2026
☕Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and interferes with the cytoprotective roles of PABPC1 and MKRN1. bit.ly/49kgpZN
bit.ly
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
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Todd Douglas @apoptoddic.bsky.social · 24/05/2026
Police don't make communities safe.
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Todd Douglas @apoptoddic.bsky.social · 30/04/2026
Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social www.nature.com/articles/s41... We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
nature.com
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
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Todd Douglas @apoptoddic.bsky.social · 30/04/2026
Thanks so much Ian! You really paved the way.
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Todd Douglas @apoptoddic.bsky.social · 30/04/2026
Thanks so much for sharing!
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Todd Douglas @apoptoddic.bsky.social · 30/04/2026
Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social www.nature.com/articles/s41... We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
nature.com
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
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Rutger Bregman @rutgerbregman.com · 04/03/2026
The international boycott of ChatGPT has absolutely exploded. 2.5M people have already joined, and this is just the beginning. Go to quitgpt.org. Cancel your subscription, delete your account. And tell at least one person why. My op-ed: www.theguardian.com/commentisfre...
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Rune Busk Damgaard @rbdamgaard.bsky.social · 24/02/2026
This project started with confusion 🤔 www.nature.com/articles/s41... Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects. Neither LUBAC nor OTULIN had been linked to metabolic regulation. So where do these metabolic manifestations come from?
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Todd Douglas @apoptoddic.bsky.social · 09/02/2026
these are my politics if you even care
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Bill McKibben @billmckibben.bsky.social · 17/01/2026
So moved by the people of Minnesota who—drawing on LA, Portland, Chicago, DC etc—are writing a shining new chapter in the history of nonviolent resistance. The rest of us need to be taking notes—and helping them! www.standwithminnesota.com
standwithminnesota.com
Stand With Minnesota
A directory of places to give to as Minnesota defends itself from ICE occupation
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Stand Up for Science! @standupforscience.net · 01/01/2026
2025 sucked. In 2026, we are taking back our science! We are excited to launch our Substack: The Science Fight Club. Read our first post, written by @cdelawalla.bsky.social, a review of 2025, a preview of 2026, and a big call to action. open.substack.com/pub/sciencef...
In all red: "Science fight club, established 2025". With a fist holding a beaker.
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IndivisibleMontgomery @indivisiblemontmd.bsky.social · 25/12/2025
In thinking about what you can do this year, keep this in mind: showing up at protests has real impact - - www.theguardian.com/us-news/2025...
theguardian.com
How effective is protesting? According to historians and political scientists: very
From emancipation to women’s suffrage, civil rights and BLM, mass movement has shaped the arc of US history
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Todd Douglas @apoptoddic.bsky.social · 09/12/2025
Beautiful work!
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Todd Douglas @apoptoddic.bsky.social · 21/11/2025
checking in on news after 2 weeks without social media
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Al Jazeera English @aljazeera.com · 08/11/2025
In Sudan, war is being waged on women and children — #AJOpinion by reena ghelani. 🔗: aje.io/z8s64p
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Todd Douglas @apoptoddic.bsky.social · 05/11/2025
is this what hope feels like??????????
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Brian Goldstone @brian-goldstone.bsky.social · 29/10/2025
Under Trump, the draconian future of homelessness policy is coming into focus: mass internment. Utah is building a 16-acre site to detain up to 1,300 homeless people inside locked "accountability centers." This is profoundly alarming. Vital reporting from @ellenbarry.bsky.social and Jason DeParle:
nytimes.com
In Utah, Trump’s Vision for Homelessness Begins to Take Shape
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Michael E. Mann @michaelemann.bsky.social · 29/10/2025
"22 of Earth's 34 'vital signs' are flashing red, new climate report reveals — but there's still time to act" | Nice article on our new #Bioscience article by @saschapare.bsky.social for @livescience.com: www.livescience.com/planet-earth...
livescience.com
22 of Earth's 34 'vital signs' are flashing red, new climate report reveals — but there's still time to act
Earth's systems are nearing tipping points that could plunge the planet into a "hothouse" regime — but there's still time to prevent that from happening, scientists say.
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@LaBonneLaB @labonnelab.bsky.social · 20/10/2025
Dear all, A scientist from UNC Chapel Hill, Paul Maddox, is running for congress in NC for a seat currently held by a republican. If you care about science (and democracy) please consider donating to his campaign #Standupforscience secure.actblue.com/donate/paul-...
secure.actblue.com
Donate to Paul Maddox for Congress in NC 11
Paul is running for Congress because there’s a sickness in Washington, and no one is working to cure it.
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Todd Douglas @apoptoddic.bsky.social · 19/09/2025
Great independent journalism from @marisakabas.bsky.social!
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Todd Douglas @apoptoddic.bsky.social · 28/08/2025
Wow, this is awesome -- beautiful work!!
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The New York Times @nytimes.com · 17/08/2025
In @nytopinion.nytimes.com “Gaza represents not some distant and inevitable tragedy, but our own moral and practical failing,” our columnist Nicholas Kristof writes. “We have blood on our hands.”
nyti.ms
Opinion | Answering My Critics About the War in Gaza
Why I believe American support for Israel in this conflict is a moral and practical failure.
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Mark Chadbourn @chadbourn.bsky.social · 10/08/2025
BBC International Editor Jeremy Bowen has confirmed that the entire Al Jazeera team in Gaza City has been killed.
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Michael Yarbrough (he/him) @mwyarbrough.bsky.social · 10/08/2025
This is the first example I've seen of a university trying to mobilize constituents to stand up against Trump threats. There's been a lot of "wHaT eLsE CaN AdMiNiStRaToRs Do?" in The Discourse when this is exactly the thing they haven't been doing. Good for UCLA for trying. Others should follow.
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Michael E. Mann @michaelemann.bsky.social · 08/08/2025
Scientists decry Trump energy chief’s plan to ‘update’ climate reports: ‘Exactly what Stalin did’ [yeah, that was me] | Mark Oliver for @theguardian.com: www.theguardian.com/us-news/2025...
theguardian.com
Scientists decry Trump energy chief’s plan to ‘update’ climate reports: ‘Exactly what Stalin did’
Ex-fossil fuel executive Chris Wright said administration is reviewing national assessments made by past governments
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Todd Douglas @apoptoddic.bsky.social · 31/07/2025
Given the state of things, self promotion is weighed down by extra shame and dissonance these days, but here is some personal news anyway: I have Emerged, per @weillinstitute.bsky.social! Very grateful for this award and the opportunity to share my work from @craigmcrews.bsky.social's lab.
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Alexandria Ocasio-Cortez @aoc.bsky.social · 03/07/2025
I don’t think anyone is prepared for what they just did w/ ICE. This is not a simple budget increase. It is an explosion - making ICE bigger than the FBI, US Bureau of Prisons, DEA,& others combined. It is setting up to make what’s happening now look like child’s play. And people are disappearing.
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The Nation Magazine @thenation.com · 25/06/2025
Zohran Mamdani just caused a political earthquake. What happens next is anyone's guess. Read John Nichols on a seismic night for New York City and the Democratic Party.
thenation.com
Zohran Mamdani Proves That Power Belongs to the People
In a rebuke to cynical Democratic insiders and the New York Times editorial page, voters backed a democratic socialist for mayor of the nation’s largest city.
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Todd Douglas @apoptoddic.bsky.social · 22/06/2025
I think a new name should be used only if the actual mechanism by which the cells die is distinct from known pathways (e.g. cuproptosis). Here they show TNF + efferocytosis = casp8 pyroptosis. The casp8-GSDMD axis is well known, so imo a new name is not warranted. Great paper, just my 2 cents!
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Michael E. Mann @michaelemann.bsky.social · 19/06/2025
I'll be on #BBCWorld News America tonight ~6:40pm ET to discuss the rapidly shrinking window of opportunity to avert dangerous 1.5C/3F planetary warming, and our new research tying rise in persistent summer weather extremes to human-caused warming. Please tune in: www.bbc.co.uk/programmes/n...
bbc.co.uk
BBC News - BBC World News America
In-depth reports on the major international and US news of the day.
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Dr. Aaron Thierry @thierryaaron.bsky.social · 19/06/2025
In the past year we've had a series of papers with results that've shocked #climate scientists - the globe is heating #FasterThanExpected & we don't fully know why The public discourse is not keeping up. Here's a series of 5 new studies that climate hawks & journos need to have on their radar 🧵
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Todd Douglas @apoptoddic.bsky.social · 14/06/2025
no kings, no billionaires, no genocide!! today at 1pm on the New Haven Green www.mobilize.us/mobilize/eve... @standupforscience.bsky.social
mobilize.us
New Haven: No Kings, No Billionaires, No Genocide! · Mobilize
NO KINGS is a national day of action and mass mobilization in response to increasing authoritarian excesses and corruption from Trump and his allies. We’ve watched as they’ve cracked down on free spee...
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Senator Alex Padilla @padilla.senate.gov · 12/06/2025
If that’s what they do to a United States Senator with a question, imagine what they can do to any American that dares to speak up. We will hold this administration accountable.
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Ben Collins @bencollins.bsky.social · 12/06/2025
"Liberate this city from socialists and burdensome leadership." If that's not regime change, I don't know what to tell you. The inflection point is now.
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