Milind et al. explore why loss-of-function variants and duplications tend to have average effects in the same direction on 94 complex traits. Using gene dosage response curves (GDRCs), they gather evi...

Abstract. The Human Genome Diversity Project (HGDP) began in 1991 as an initiative to study genetic variation from human populations worldwide. In 2002, th

Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To un...

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

Scientific Reports - scATAC-seq generates more accurate and complete regulatory maps than bulk ATAC-seq

All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key drivers of young-onset ...

ALT: homer simpson from the simpsons is holding a cup in front of a picture

ALT: a cartoon of homer simpson holding a card

A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying promising biomarkers...