Glutathione (GSH) robustly defends against ferroptosis independently of GPX4. FSP1 utilizes GSH to reduce ubiquinone and subsequently inhibits ferroptosis, which is distinct from the NAD(P)H-FAD axis....

Tumor reliance on antioxidant defenses creates a vulnerability to ferroptosis, yet strategies to therapeutically disable these systems remain limit...

Endogenous mechanisms that restrain inflammation remain incompletely understood. Colussi et al. identify membrane phospholipids as reservoirs of endogenous nitrated fatty acids that are rapidly mobilized during inflammatory stress. Release of NO2-CLA suppresses inflammatory signaling and preserves vascular homeostasis, revealing a previously unrecognized anti-inflammatory reserve that becomes depleted during disease.

Large networks are particularly beneficial to researchers in under-represented groups.

Popular vendors’ catalogs feature more than 18,000 manipulated images

Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...

Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...

This Review examines the chemical complexity of selenium biology and the tools available to study it. Defining current limitations in detecting selenium species outlines pathways toward a more precise...

This Review examines the chemical complexity of selenium biology and the tools available to study it. Defining current limitations in detecting selenium species outlines pathways toward a more precise...

O pesquisador brasileiro José Pedro Friedmann Angeli foi premiado por avanços na ferroptose, mecanismo que pode combater tumores agressivos e resistentes.

The Medical Research Council Mitochondrial Biology Unit (MRC MBU), University of Cambridge, wishes to appoint two post-doctoral Research Associates to join the research group of Prof. Mike Murphy at t...

The Heidelberg Medical Faculty of the University of Excellence Heidelberg is an outstanding location for innovative research, both nationally and i...

A multi-institute research team, led by Prof. José Pedro Friedmann Angeli, examined the activity of ferroptosis suppressor protein 1 (FSP1) in protecting against phospholipid peroxidation and ferropto...

Hinshaw et al. determine the molecular basis for TRIM21 recruitment to the nuclear pore protein NUP98, showing that an induced protein-protein interface drives the potency and selectivity of the molecular glue mechanism.

Oncogenesis - Metabolic vulnerabilities and therapeutic opportunities in diffuse large B-cell lymphoma

Clause says those aged up to 45 may need permission from armed forces to leave country for more than three months

The 2026 Gordon Research Conference on Thiol-Based Redox Regulation and Signaling will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.