The microscopy expert put the big-clawed animal through his micro-CT scanner, creating an incredibly detailed image of its body.

The authors report that a change to lysosome morphology, from vesicular to tubular form, supports lifespan extension upon dietary restriction and promotes heightened autophagy and healthy aging when s...

This study reveals that transcription factors DAF-16/FOXO and HLH-30/TFEB promote healthy aging in C. elegans, in part, by activating lipid metabolism genes that remodel lysosomes into tubular network...

Biological sciences; Genetics; Neuroscience

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Frontiers for Young Minds, an award-winning science engagement journal for kids, is proud to share three new articles written by Nobel Prize-winners. These thre

The Trump administration’s decision to cap how much NIH will pay for indirect costs on university research grants would cost 10 red states more than $1 billion.

Summary: Increasing lysosome activity in the fly midgut offsets negative effects of an obesogenic high-fat diet.

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Hahn et al. report the presence of 6mA, a DNA modification, on the mitochondrial (mt)DNA of various animal and plant species. Modulating the activity of 6mA enzymatic modifiers implicates 6mA in regulating mtDNA replication and expression and the transmission of mtDNA mutations across generations, ultimately affecting mitochondrial health and organismal lifespan.

Nature Cell Biology - Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. Initiatives such as the Women in...

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

Endogenous mitochondrial NAD(P)H fluorescence enables label-free and subcellular resolution quantification of aging, prediction of remaining lifespan and tracking of age-dependent changes to mitochond...

The activation of mTORC1 is intricately linked to its subcellular localization, with the Rag GTPases controlling its lysosomal recruitment in response to nutrient cues. Acharya and Demetriades uncover...

She is the first person with type 1 diabetes to receive this kind of transplant.

Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

Health effects of dietary restriction are uncoupled from longevity.