This week we discussed the following paper from @adamnorris.bsky.social lab. It’s super cool that they use splicing reporters which reveal how cells splice a transcript at single neuron level. www.cell.com/callback?red...
cell.com
Spliceosomal component PRP-40 is a central regulator of microexon splicing
Microexons play crucial roles in neuronal function but pose mechanistic challenges
to the spliceosome. Choudhary et al. reveal that PRP-40, a core spliceosomal component,
is required for microexon inc...