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Steve Middleton

@middletonsj.bsky.social
64 followers 100 following 2 posts

Post Doc • Bennett Lab • Pain and Sensory Biology • Research Fellow, @WolfsonCollege • University of Oxford • 🏳️‍🌈

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Steve Middleton @middletonsj.bsky.social · 21/08/2025
We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future! www.nature.com/articles/s41...
nature.com
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
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Reposted by Steve Middleton
Sigurbjörn Markússon @sigurbjornm.bsky.social · 21/08/2025
Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!
nature.com
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
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Reposted by Steve Middleton
Nuffield Department of Clinical Neurosciences @ndcnoxford.bsky.social · 21/08/2025
📣 NEW: Breakthrough discovery of a genetic link to pain co-led by NDCN's Prof David Bennett and Prof Simon Newstead @oxfordbiochemistry.bsky.social The results of the research, published in @nature.com, could lead to a promising new target for the treatment of #chronicpain.
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