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Alfred Kim

@alhkim.bsky.social
469 followers 418 following 14 posts

Founder/Director @WUSTL_Lupus @WUSTLMed | Assoc Program Director @WashUMedRheum.bsky.social | Chief Medical Officer, Kypha, Inc | Complement, Lupus ORCID iD: 0000-0003-4074-0516 profiles.wustl.edu/en/persons/alfre…

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Reposted by Alfred Kim
Ariella Studies @ariellastudies.bsky.social · 30/09/2025
The old version and the new (Powerpoint-friendly, content edits by @alhkim.bsky.social ) version of the lupus overview graphic ~ #MedSky #RheumSky (do we still use hashtags here? i feel old 👵)
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Alfred Kim @alhkim.bsky.social · 21/03/2025
Oh please keep the “verbiage” so this keeps an NC-17 rating. I can tell my dad that I’m still doing good stuff with my career.
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Reposted by Alfred Kim
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 21/03/2025
Recording an episode of @freelyfiltered.bsky.social with @kidneyboy.bsky.social and @jenniejlin.bsky.social with special guests @alhkim.bsky.social Koyal Jain and Brad Rovin No surprises on what recent #NephJC study we are discussing 👑
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Scott Delaney @scott-delaney.bsky.social · 21/02/2025
NIH indirects case update: Hearing ongoing now, and I'll try to live tweet some notable exchanges. Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides: (I'm paraphrasing here)
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Reposted by Alfred Kim
John Hawkinson @johnhawkinson.bsky.social · 21/02/2025
COMING UP at 10am, the preliminary injunction hearing in the consolidated Boston cases against NIH (Mass v., AAU v., AAMC v.). Oral argument time is divided thus:
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Reposted by Alfred Kim
Mithu Maheswaranathan, MD @mithurheum.bsky.social · 12/02/2025
🆕 #Obinutuzumab (Obi) in Lupus Nephritis: the REGENCY Trial Phase 3 RCT: Obi vs PBO 🫘 Pts w/ SLE nephritis Class III/IV ± 5 🎲 Randomized 1:1 to OBI v PBO (+MMF/steroids) 📊 Obi: ⇡rate of renal response and improved renal outcomes #LupusNephritis #RheumSky #NephSky #MedSky #Lupus
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E John Wherry @ejohnwherry.bsky.social · 08/02/2025
This will kill science in the US. This is how China wins. Why is this not on the news? Why are people not more upset about this? grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
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Reposted by Alfred Kim
Tim Clancy @viewfromarchstreet.com · 08/02/2025
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH
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Reposted by Alfred Kim
Grant Schulert, MD, PhD @grantschulert.bsky.social · 08/02/2025
This is a massive hit to academic medical centers - probably unilaterally cuts their NIH dollars by 20%. Lots of folks are going to lose their jobs:
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Reposted by Alfred Kim
Grant Schulert, MD, PhD @grantschulert.bsky.social · 08/02/2025
Last year 90% of members of the US Air Force didn’t even fly planes! MaSIvE GOverNMeNt wAsTE!! Or - they do all the other essential things to keep the mission running, including really boring things like cutting paychecks, cooking, and even being pediatricians to airmen/women’s kids
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Alfred Kim @alhkim.bsky.social · 08/02/2025
Similar to how the medical world realized how over-reliant they’ve been on elective procedures for generating revenue, academic institutions similarly got lazy. How they innovate around this will be interesting, and way above my pay grade.
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Alfred Kim @alhkim.bsky.social · 08/02/2025
I don’t buy that federal grants are better because they are longer and have higher direct cost caps: these grants still do not cover the true costs for the research funded anyway.
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Alfred Kim @alhkim.bsky.social · 08/02/2025
Hmmm. Part of this is the fault of academic institutions IMO: the financial reliance on governmental indirect costs led to the strong link to get federal grants for faculty promotion. No matter how many grants you get from private foundations, lack of governmental funding is a strike against you.
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Alfred Kim @alhkim.bsky.social · 08/02/2025
Holy shit…ALL indirect rates for NIH grants slashed to 15% (if I’m reading this correctly?) grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
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Reposted by Alfred Kim
Rheum Cat @rheumcat.bsky.social · 06/02/2025
I’ve seen this film before. @alhkim.bsky.social @jeffsparks.bsky.social @kristenyoung.bsky.social @situationrheum.bsky.social
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Reposted by Alfred Kim
Saloni @scientificdiscovery.dev · 01/02/2025
“A group of researchers and students at the Harvard T.H. Chan School of Public Health is gathered today for a data preservation marathon, scraping and downloading data related to health equity from U.S. government agency websites before they disappear.”
journalistsresource.org
Researchers rush to preserve federal health databases before they disappear from government websites
Journalists have long relied on federal health data for their reporting. We include several tips that they can use to help researchers preserve the data.
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Reposted by Alfred Kim
Charles Ornstein @charlesornstein.bsky.social · 31/01/2025
This is a big deal, y'all. Federal health websites are being stripped of content or removed in their entirety. Stick with this thread for a look at what's disappeared so far! 1/x
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Alfred Kim @alhkim.bsky.social · 31/01/2025
Our hospital system (Barnes-Jewish) uses the Mayo Clinic Labs “CRY-S” (www.mayocliniclabs.com/test-catalog...) test, which is cryocrit-based with a reflex immunofixation. What is this Ig quant test, never heard of it!
mayocliniclabs.com
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Alfred Kim @alhkim.bsky.social · 18/01/2025
I feel that the antigen will always be there, and coupled with any memory responses, there could be persistent activation of these B cells.
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Reposted by Alfred Kim
pedrheumdoc.bsky.social @pedrheumdoc.bsky.social · 18/01/2025
What pediatric rheumatology workshop would adult rheumatologists find most useful at a conference?
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Alfred Kim @alhkim.bsky.social · 18/01/2025
So RTX does not deplete B cells from lymph nodes & likely inflamed organs. Curious in the non-responders what the C3 nephritic factor levels are. If high, they are coming from long-lived plasma cells (I’d hypothesize). If they drop, then it argues that tissue B cells are contributing to pathology.
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Alfred Kim @alhkim.bsky.social · 18/01/2025
Good question: depends if it is coming from plasmablast or plasma cells. Most SLE autoAbs come from extrafollicular activated B cells that differentiate into “pre-plasma cells,” which are plasmablast precursors. They are indirectly depleted with RTX. pubmed.ncbi.nlm.nih.gov/30314758/
pubmed.ncbi.nlm.nih.gov
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus - PubMed
Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5<sup>-</sup> CD11c<sup>+</sup> cel...
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Alfred Kim @alhkim.bsky.social · 18/01/2025
Sounds like we need to look, and yes, @anujajava.bsky.social has asked me before. We have ~400 patients with classified lupus we could query.
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Reposted by Alfred Kim
James Zou @jameszou.bsky.social · 18/12/2024
🎆4 years in the making! Thrilled to share the 1st spatial single cell aging clock ⏰ www.nature.com/articles/s41... We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain 🧠 Led by Eric Sun and awesome collaboration w/ @brunetlab.bsky.social🧵
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Alfred Kim @alhkim.bsky.social · 13/12/2024
Look who’s migrated over to @bsky.app: @zahitouma.bsky.social!! You better give him a follow.
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Reposted by Alfred Kim
Mark Cuban @mcuban.bsky.social · 10/12/2024
If you want to understand why healthcare pricing is horrific, the first thing to know is that our system puts 100% of the credit risk for deductibles, copays and co-insurance on hospitals and doctors. That's insane. We have turned them into Sub Prime Lenders 🧵
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Alfred Kim @alhkim.bsky.social · 10/12/2024
Andrea continues to delve deeply into the utility of urinary biomarkers for lupus nephritis. We both provide deeper insight into this massive unmet need in lupus nephritis on @medpagetoday.bsky.social: nam10.safelinks.protection.outlook.com?url=https%3A...
nam10.safelinks.protection.outlook.com
Lupus Nephritis Biomarkers ‘Robustly’ Predict Organ Damage
With an accuracy of 86%, the biomarker panel has the potential to be clinically useful in diagnosis, management, and prognosis of lupus nephritis.
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Alfred Kim @alhkim.bsky.social · 10/12/2024
franklypenn.com/wp-content/u... CAS ‘96
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Reposted by Alfred Kim
Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 08/12/2024
Surprise case of immunotactoid glomerulopathy in a biopsy for longstanding proteinuria thought to be due to chronic HTN. ~30nm microtubular structures. IgG2-kappa restricted. MGRS lesions, often associated with lymphoma bit.ly/3NNpwVd. #renalpath #pathsky #nephsky
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Reposted by Alfred Kim
Jeffrey Sparks MD MMSc @jeffsparks.bsky.social · 24/11/2024
Our latest paper is out, led by Dr Vanessa Kronzer- Using data from the Mayo Clinic and Mass General Brigham Biobanks, we found strong gene-respiratory disease interactions for risk of rheumatoid arthritis ard.bmj.com/content/earl...
ard.bmj.com
Uncovering specific genetic-respiratory disease endotypes for rheumatoid arthritis risk
Objective We aimed to identify specific genetic-respiratory disease endotypes for rheumatoid arthritis (RA) risk. Methods This case–control study used the Mass General Brigham (MGB) and Mayo Clinic (...
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Reposted by Alfred Kim
Jon Lim, FRCP PhD @drjonlim.bsky.social · 23/11/2024
🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov
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@THEE Ashira Blazer MD @ashira-md.bsky.social · 21/11/2024
🗣️GO TO SLEep!🗣️ My first and best advice to my patients was captured in this #ACR24 gem, “Chasing Zzzs in Rheumatic Disease…” by dear friends @alhkim.bsky.social @yvonne-lee.bsky.social and Patty Katz. Let’s get into it!
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Jinoos Yazdany @jyazdanymd.bsky.social · 18/11/2024
#ACR24 lupus nephritis guideline puts nickel down on choosing CNI if proteinuria >3 grams based on post-hoc analysis of BLISS-LN. Hopefully a head-to-head comparison of adding BEL or CNI or OBI will happen at some point
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Reposted by Alfred Kim
Max Konig @maxkonigmd.bsky.social · 17/11/2024
Targeting autoreactive TRBV9+ T cells using TRBV9xCD3 bispecific T cell engaging antibodies. Controlling ankylosing spondylitis and celiac disease without increasing the risk of infection? Let's go. Join us at Room 150, 3:00 PM. #precisionimmunotherapy #ACR24
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Max Konig @maxkonigmd.bsky.social · 17/11/2024
While at it, if you are interested in learning more about off-the-shelf precision immunotherapies for the treatment of lupus, please join our talk on 9G4xCD3 T cell-engaging antibodies during the SLE - Cellular Therapy Session at 3 PM. #ACR24
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Michael Paley, M.D., Ph.D. @drmapaley.bsky.social · 17/11/2024
I’ll be presenting at 3pm in Ballroom B (1755) on “Single Cell TCR Sequencing Suggests Potential Limitations of TRVB9-depleting Therapies in Axial Spondyloarthritis”. Would love to chat about our work if you stop by! @washumedrheum.bsky.social #ACR24
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Rheum Cat @rheumcat.bsky.social · 14/11/2024
I found @alhkim.bsky.social and he has the F F F bracelet @laceyfeigl.bsky.social #ACR24
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Rheum Cat @rheumcat.bsky.social · 14/11/2024
#ACR24 plenary preview / highlights
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Alfred Kim @alhkim.bsky.social · 13/11/2024
Hey there! Please add me too!
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