Bayesian hierarchical modeling of cross-platform DNA methylation data enables detection of tissue-specific and cancer-associated signatures in MeDIP-seq measurements of bulk and cell-free DNA.

This opinion piece discusses the Bioconductor project for open-source bioinformatics and the engineering concepts underlying its effectiveness to date. Since the inception of Bioconductor in 2002 with...

Queen’s University is a globally engaged, research-intensive institution dedicated to attracting and supporting exceptional PhD students who will significantly advance our research mission.

Dong et al. characterized the significant advantages of reference genome updates, specifically the T2T-CHM13 and the human pangenome, in DNA-methylation analyses. Compared to the previous GRCh38 assem...

MeDIP-seq is an enrichment-based DNA methylation profiling technique that measures the abundance of methylated DNA. While this technique offers efficiency advantages over direct methylation profiling,...

Select SFU graduate programs are opening their applications particularly for Canadian students choosing to remain and study in Canada as well as US students looking to study outside the US. Applicatio...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

As announced in Budget 2024, the scholarship and fellowship programs administered by the three federal research funding agencies – the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC), and the Social Sciences and Humanities Research Council (SSHRC) – have been streamlined into a new harmonized talent program called the Canada Research Training Awards Suite (CRTAS) that will open for applications in summer 2025.

The War on Science What’s happening? What can we do about it? An interactive teach-in for biomedical researchers Please share, modify, and repurpose this template presentation (with credit). Good luck...

The NIH said Friday night that it would slash support for indirect costs on all existing and future grants to 15%

UMAP is a powerful tool for exploratory data analysis, but without a clear understanding of how it works, it can easily lead to confusion and misinterpretation.

How to balance open data sharing and public responsibility

YouTube video by Prof. Jean Fan

Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...

Single-cell DNA methylation measurements reveal genome-scale inter-cellular epigenetic heterogeneity, but extreme sparsity and noise challenges rigorous analysis. Previous methods to detect variably m...

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Clinical decisions are often guided by clinical prediction models or diagnostic tests. Decision curve analysis (DCA) combines classical assessment of predictive performance with the consequences of u...

The Bioconductor project aims to develop and share open source software for precise and repeatable analysis of biological data. We foster an inclusive and collaborative community of developers and dat...

The Department of Statistics in the Faculty of Science at the University of British Columbia (UBC), Vancouver invites applications from outstanding new investigators for two tenure-track positions at ...

Dimension reduction helps to visualize high-dimensional datasets. These tools should be used thoughtfully and with tuned parameters. Sometimes, these methods take a second thought.

Criticism of our decision to publish AlphaFold3 raises important questions. We welcome readers’ views. Criticism of our decision to publish AlphaFold3 raises important questions. We welcome readers’ v...