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A.S.H.

@alexanderhatoum.bsky.social
85 followers 238 following 25 posts

Medical Researcher studying substance use disorders with statistical genetics, biomarker data, and machine learning/AI.

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Reposted by A.S.H.
Lydia Rader @lydiarader.bsky.social · 20/03/2026
Check out our new paper! We found general chronic pain is genetically linked to broad addiction liability, while musculoskeletal pain shows more substance-specific genetic associations, particularly with tobacco and alcohol use. Link: onlinelibrary.wiley.com/share/author...
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 10/12/2025
1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
nature.com
Mapping the genetic landscape across 14 psychiatric disorders - Nature
Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...
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Stephen Turner @stephenturner.us · 13/11/2025
The Drain of Scientific Publishing arxiv.org/abs/2511.04820
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A.S.H. @alexanderhatoum.bsky.social · 17/09/2025
Definitely D. Almost all of middle, south, and Eastern Asia is in there. Even southern Italy!
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Brilliant Maps @brilliantmaps.bsky.social · 16/09/2025
For the rest of your life, you can only eat food from one of these regions. Which do you choose? For more maps: brilliantmaps.beehiiv.com/s...
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A.S.H. @alexanderhatoum.bsky.social · 06/08/2025
Those three principles are 1. Modeling disorders as polygenic. 2. Including control for population stratification. 3. Awareness of environmental context. Now out on pubmed!
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A.S.H. @alexanderhatoum.bsky.social · 06/08/2025
We lay out three consensuses from the field of psychiatric genetics that should be considered before approving genetic tests for psychiatric disorders. The letter was signed by 140 experts in psychiatric genetics and published in Lancet Psychiatry. Now on Pubmed: pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Concerns About Genetic Risk Testing for Opioid Use Disorder
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A.S.H. @alexanderhatoum.bsky.social · 06/08/2025
For those that read their papers on bluesky, those three principles are 1. Modeling disorders as polygenic. 2. Including control for population stratification. 3. Awareness of environmental context.
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A.S.H. @alexanderhatoum.bsky.social · 01/08/2025
That’s honestly a breathtaking and needed effort
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A.S.H. @alexanderhatoum.bsky.social · 15/07/2025
Then let me tell you about Jean Baudrillard.
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A.S.H. @alexanderhatoum.bsky.social · 15/07/2025
You gotta play “smells like teen spirit” if it’s an adolescent psychiatry conference.
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A.S.H. @alexanderhatoum.bsky.social · 02/06/2025
I feel this in my bones.
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A.S.H. @alexanderhatoum.bsky.social · 16/05/2025
Sample size, discovery power, and effect size of lead SNPs were the strongest determinants of enrichment, as opposed to biological function. I hope it serves as a demonstration of the practical benefit of scientific discovery. I'd like to thank my Coauthors.
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A.S.H. @alexanderhatoum.bsky.social · 16/05/2025
Those disorders with larger sample sizes in their GWAS discovery set were significantly enriched for current treatments for those disorders. Those were, schizophrenia, bipolar disorder, MDD, and SUDs. Those disorders with smaller samples were not (yet!) enriched.
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A.S.H. @alexanderhatoum.bsky.social · 16/05/2025
Collecting large genome-wide samples may de-risk reinvestment in psychopharmaceuticals. Expanding on past work that lumped all psychiatric disorders together, we conducted a test of the utility of GWAS for specific psychiatric indications. www.nature.com/articles/s43...
nature.com
Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries - Communications Medicine
Hatoum et al. undertake exploratory analysis of genome-wide association studies of specific psychiatric disorders to find existing medications that treat those disorders and genetic pathways that may ...
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A.S.H. @alexanderhatoum.bsky.social · 09/05/2025
Casey Means? Sounds pretty average to me *nudge*.
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A.S.H. @alexanderhatoum.bsky.social · 04/05/2025
My mandalorian friend asked me which protein powder I use and I told him “this is the whey”. Happy #MayTheFourth
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A.S.H. @alexanderhatoum.bsky.social · 18/04/2025
Let’s say a person from the US wanted to apply and move to Europe. Is there somewhere with step by step advice? Would we need to find a collaborator. Asking for a friend…..
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A.S.H. @alexanderhatoum.bsky.social · 18/04/2025
There are articles out there on lesions in deep neural networks in many applications. LLMs can do it in multiple ways, one is attention mapping (as @michelnivard.bsky.social pointed out). Do you know what they used the lesion to test? Was it attention or something else? It would help me find it.
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Private Eye Magazine @privateeyenews.bsky.social · 03/04/2025
“Er, my question is really in two parts…” From the new Private Eye, out now.
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A.S.H. @alexanderhatoum.bsky.social · 31/03/2025
If you think our academia is unstable, wait until you see our industry!
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Brian Trainor @briantrainor.bsky.social · 21/03/2025
Getting the message out on how science funding benefits our society @abepalmer.bsky.social in the SD Tribune www.sandiegouniontribune.com/2025/03/09/g...
sandiegouniontribune.com
Guest Commentary: Medical research saves lives and helps our community. It deserves the funding it gets
Abraham Palmer, a La Jolla resident and psychiatry professor at UC San Diego, objects to cuts in funding for work that fights diseases
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David Baranger @davidbaranger.bsky.social · 20/03/2025
The BEAR Lab will be opening it's doors in July at the Medical College of Wisconsin, and we are looking for our first Research Tech! This position will help with funded MRI studies looking at the brain and alcohol use. More info: bearlab.science/contact/ #neuroscience #psychology #sciencejobs
bearlab.science
Contact
We are actively recruiting a Research Technologist! (start date ~7/1/25) Job ad is coming soon. This position will primarily assist with funded studies examining brain function in people who drink …
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A.S.H. @alexanderhatoum.bsky.social · 16/03/2025
Thanks for sharing this thread and your thoughts. I’ve been thinking along the same lines recently.
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A.S.H. @alexanderhatoum.bsky.social · 15/03/2025
So where does the AI race end? Space race was the moon. AI..also the moon?
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A.S.H. @alexanderhatoum.bsky.social · 15/03/2025
Np. Reddit accounts are good for this kind of thing. I know it’s got a lot of bad too, but people there are much better at this than I am.
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A.S.H. @alexanderhatoum.bsky.social · 15/03/2025
I’m not familiar with that plant species, but generally what I would do since I can’t tell if it’s fungal or bacterial.
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A.S.H. @alexanderhatoum.bsky.social · 15/03/2025
Yellowing could also be bacterial.
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A.S.H. @alexanderhatoum.bsky.social · 15/03/2025
Could be an early fungal infection given the yellowing around the leaves. It doesn’t seem to be a pest. If the leaves are falling off prematurely, I’d look to see if spots with yellowing keep showing up and start to spread. Septoria would be my guess but not sure. Also could be simple singing.
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A.S.H. @alexanderhatoum.bsky.social · 12/03/2025
One can only hope.
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Alice Braun @alicebraun.bsky.social · 12/03/2025
The Ripke lab has worked on a new stable release of RICOPILI! Updates include compatibility with GRCh38 and imputation using Minimac4. A software tarball and YAML file are provided to help resolve dependency issues: github.com/Ripkelab/ric... Any feedback is highly welcome! @pgcgenetics.bsky.social
github.com
GitHub - Ripkelab/ricopili: Main ricopili repo for public releases
Main ricopili repo for public releases. Contribute to Ripkelab/ricopili development by creating an account on GitHub.
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A.S.H. @alexanderhatoum.bsky.social · 08/03/2025
Spoke at the Missouri @standupforscience.bsky.social this morning. Good to get out of the lab and affirm core values.
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Ted Schwaba @tedmond.bsky.social · 07/03/2025
Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41... (feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)
nature.com
Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex - Nature Genetics
Genomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric...
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Matt Czap @mattczap.bsky.social · 14/01/2025
One day you will inherit this world
But not before I make sure that every aspect of life is an absolute nightmare
And block any attempt to make it better
So what's this I hear about you not wanting to have children?
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A.S.H. @alexanderhatoum.bsky.social · 01/03/2025
Did a new one come out this week? Who is the first author so I can look it up!
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