Reposted by Lydia RaderNature Portfolio @natureportfolio.nature.com · 01/08/2026A multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals presented in Nature Medicine identifies 26 risk loci for fibromyalgia, including HTT, and finds genetic correlations with chronic pain and psychiatric and somatic disorders. go.nature.com/4q860Yp 🧬🧪 0183
Reposted by Lydia RaderLuca Sclisizzo @luca-sclisizzo.bsky.social · 27/06/2026#BGA26 was a blast! Happy to have had the opportunity to present my work in Amsterdam and share one of my favorite research topics. Thanks to @lydiarader.bsky.social, @tabeasch.bsky.social, and @evangiangrande.bsky.social for such a great discussion and for their amazing talks! 252
Reposted by Lydia RaderThe Journal of Pain @thejournalofpain.bsky.social · 22/06/2026Original: Drs. @lydiarader.bsky.social, @dangustavson.bsky.social, @torwager.bsky.social, & coll. used mixed-effects models to examine associations between polygenic scores and adolescent self-reported pain presence, intensity, recurrence, and multi-site pain. FULL: www.jpain.org/article/S152...jpain.orgAdolescent pain reports share genetic overlap with adult chronic pain conditions: A polygenic score analysis using the ABCD studyAdolescent pain complaints may be related to genetic risk for chronic pain across the life course. Identifying whether adolescent pain is genetically linked to chronic pain in adulthood can advance… 043
Lydia Rader @lydiarader.bsky.social · 11/06/2026What if some adolescent pain complaints are early manifestations of lifelong chronic pain risk? www.jpain.org/article/S152...jpain.orgAdolescent pain reports share genetic overlap with adult chronic pain conditions: A polygenic score analysis using the ABCD studyAdolescent pain complaints may be related to genetic risk for chronic pain across the life course. Identifying whether adolescent pain is genetically linked to chronic pain in adulthood can advance un... 100
Reposted by Lydia RaderDaniel Gustavson @dangustavson.bsky.social · 20/05/2026So much for "sex, drugs, and rock n' roll". A new paper by Dr. Lydia Rader shows that adolescent music engagement is related to less alcohol use & substance use experimentation 5-11 years later through protective environmental factors. @lydiarader.bsky.social pmc.ncbi.nlm.nih.gov/articles/PMC...pmc.ncbi.nlm.nih.govAdolescent Music Engagement is Associated with Less Alcohol Consumption and Substance Experimentation 5 to 11 Years Later: A Genetically Informative StudyAdolescence is a critical developmental window for shaping substance use trajectories. Music engagement during this period may reduce substance experimentation and later misuse through direct effects ... 011
Lydia Rader @lydiarader.bsky.social · 12/05/2026New paper! 🎶🎸 • Do adolescents who engage in music use less substances later in development? • Are the links direct effects or due to shared genetic/environmental influences? • Is music constructive for youth at high genetic risk for substance use? Paper link: www.researchgate.net/publication/...researchgate.net(PDF) Adolescent Music Engagement Is Associated With Less Alcohol Consumption and Substance Experimentation 5–11 Years Later: A Genetically Informative StudyPDF | Objective: Adolescence is a critical developmental window for shaping substance use trajectories. Music engagement during this period may reduce... | Find, read and cite all the research you nee... 131
Reposted by Lydia RaderSophie Breunig @breunigsophie.bsky.social · 08/05/2026New preprint alert! 🚨 Building on exciting new work in autism subtyping, we investigated how biological sex 👭 and age at diagnosis 👵 shape the genetic landscape of autism. 🧬 Check out our findings below 🧵 and the full paper here: www.researchsquare.com/article/rs-9...researchsquare.comUncovering the Role of Biological Sex in the Divergent Genetic Profiles of Early and Late-Diagnosed AutismAutism spectrum disorder (ASD) is a neurodevelopmental disorder with a significant male prevalence bias. While recent evidence suggests that genetic heterogeneity is indexed by age at diagnosis, males... 141
Reposted by Lydia Raderlaurawesseldijk.bsky.social @laurawesseldijk.bsky.social · 29/04/2026There was a lot of laughter during this conversation and a few secret confessions... But we also had some great discussions about musicality, genetics, Beethoven and public outreach, mental health, and music genres... Thank you @rafaelahlskog.bsky.social and @aysuo.bsky.social for having me! 🎶 1125
Reposted by Lydia RaderPAIN @painthejournal.bsky.social · 27/04/2026Yuan et al. show that neuropathic chronic low-back pain has distinct thalamic brain changes compared to non-neuropathic low-back pain, underscoring the need to distinguish between these phenotypes to reduce heterogeneity in future studies #PAIN bit.ly/4msHe3i 021
Reposted by Lydia Rader Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 27/04/2026New Scientific Reports article lead by IBG graduate student @eamonnduffy.bsky.social and faculty member Marissa Ehringer finds genetically divergent rat strains differ in oxycodone self-administration and effects on gut microbiome. Congrats to the team on this work! www.nature.com/articles/s41...nature.comOxycodone self-administration and genetic background exert community-specific effects in the gut microbiome - Scientific ReportsThe gut microbiome and genetic factors contribute to several opioid-related phenotypes in humans and animal models. Here, we examined the effects of genetic background and oxycodone self-administratio... 062
Reposted by Lydia Rader Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 10/04/2026New Nature Communications paper from IBG graduate student Jeremy Lawrence describes high genetic overlap across 73 physical illnesses (e.g., cancers, heart failure, pneumonia) and internalizing, substance use, and neurodevelopment disorders.🧬 www.nature.com/articles/s41... 183
Reposted by Lydia RaderThe Journal of Pain @thejournalofpain.bsky.social · 10/04/2026Original: Tacugue, Dr. Kossowsky et al. ( @bostonchildrens.bsky.social) found that chronic pain doesn't just hurt, it impairs memory & attention in adolescents —4 weeks of intensive rehab improved cognition, sleep & mental health Full: www.jpain.org/article/S152...jpain.orgAssessing relationships between cognition, sleep, and mental health in pediatric patients with chronic painChronic pain in adolescents commonly disrupts cognitive functioning, sleep, and mental health. Research suggests underdeveloped cognitive skills in adolescents may lead to poor self-management thus… 011
Reposted by Lydia Rader Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 23/03/2026New article published in Addiction and lead by IBG postdoc @lydiarader.bsky.social identifies transdiagnostic genetic overlap between general chronic pain and addiction risk, along with substance-specific pathways. doi.org/10.1111/add....doi.orgGenetic overlap of chronic pain, musculoskeletal‐specific pain, substance use disorders and substance use consumption: Common addiction and substance‐specific effectsBackground and aims Chronic pain and substance use disorders frequently co-occur and may share general addiction-related and substance-specific genetic pathways. Additionally, substance consumption ... 142
Lydia Rader @lydiarader.bsky.social · 20/03/2026Check out our new paper! We found general chronic pain is genetically linked to broad addiction liability, while musculoskeletal pain shows more substance-specific genetic associations, particularly with tobacco and alcohol use. Link: onlinelibrary.wiley.com/share/author... 184