Externalizing spectrum disorders- spanning attention-deficit/hyperactivity disorder, conduct disorder, substance use disorders, and other disorders characterized by disinhibition - frequently co-occur...

Not with a bang but with a whimper

Ending the federal LGBTQ+ suicide prevention line is a public health failure, write two leaders in prevention and crisis response.

Heritability of Humor Production Ability — A Twin Study

Identifying individuals at elevated risk before disease onset is a cornerstone of personalized prevention, and polygenic scores (PGSs) have proven to be instrumental in this regard. In this study, we ...

A new culture of secrecy in government is taking root – among career staffers and new political appointees alike.

YouTube video by Center for Suicide Research and Prevention (CSRP)

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Question Is variation in global functioning among people with schizophrenia associated with genetic differences? Findings In this genetic association study of 5991 adults with schizophrenia and 59,79...

Economists find public R&D drives U.S. productivity growth — and pays for itself

Undermining the future of American science is not a path to accountability — it’s a path to decline.

Efficiency is not being enhanced, nor is waste being eliminated at the N.I.H. Scientists are just left to wonder: Why?

More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

A long-discredited researcher and vaccine skeptic will conduct a government study on whether vaccines cause autism.

npj Digital Medicine - Continuous time and dynamic suicide attempt risk prediction with neural ordinary differential equations

Apparently, mankind is prejudiced in favor of heavy brained persons. This view was bluntly expressed at a recent conference by a physician who averred that it is generally recognized that men with lar...

The worst manifestations of preventable diseases have faded from public memory.

Abrupt cuts by the Trump administration to the US National Institutes of Health threaten progress in medical research globally.

Genomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric...

Since medications are typically started when depressive symptoms re-emerge, all treatments might appear less effective than they actually are when the reference is non-use of medication. Lithium was t...

The company is making a foray into scientific discovery with an AI built to help manufacture stem cells.

Once found in the jungles of Africa, researchers in South America have now discovered links tying these extinct primates to the continent—painting an incredible story of survival against the odds.

Debate continues to rage in the scientific community about the true meaning of time, even about its very existence at a fundamental level.

Climate change, including increased heat, extended drought, and a thirsty atmosphere, has been a key driver in increasing the risk and extent of wildfires in the western United States during the last ...

Genes for which a dose-response relationship exists between mutational severity and phenotypic impact make for logical therapeutic targets, as the effects of pharmacological modulation can be anticipa...

The growing availability of pre-trained polygenic risk score (PRS) models has enabled their integration into real-world applications, reducing the need for extensive data labeling, training, and calib...

This work highlights the importance of considering methodological decision points in interpreting the impact of PRS on prediction performance in clinical models.

some counterintuitive properties of the polygenic liability threshold model

Molecular Psychiatry - Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

This article is about the neural conundrum behind the slowness of human behavior. The information throughput of a human being is about 10 bits/s. In c…

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Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...

Edward Scolnick led the development of dozens of medicines while at Merck. His current mission pits him against time and the mental illness of millions, including his son.