Adrian Saurin @adesaurin.bsky.social · 24/09/2026www.theguardian.com/books/2016/a...theguardian.comNeoliberalism – the ideology at the root of all our problemsFinancial meltdown, environmental disaster and even the rise of Donald Trump – neoliberalism has played its part in them all. Why has the left failed to come up with an alternative? 020
Adrian Saurin @adesaurin.bsky.social · 09/09/2026#Postdoc position available in my lab to study the role of senescence and senescence evasion in cancer therapy responses (available for up to 5 years) Check out www.saurinlab.com further details about project and lab culture in general. www.jobs.ac.uk/job/DSS226/p...jobs.ac.ukPost-Doctoral Researcher - UOD2267 at University of DundeeDiscover an exciting academic career path as a Post-Doctoral Researcher - UOD2267 at jobs.ac.uk. Don't miss out on this job opportunity - apply today! 000
Reposted by Adrian Saurinjerome mutterer @jmutterer.bsky.social · 28/08/2026I've made a video about Fig_Space, the next version of FigureJ. It has nice new features, I hope you like it. youtu.be/bTKcXN4p-JMyoutu.beFigSpace Fiji plugin demoYouTube video by jerome mutterer 13113
Reposted by Adrian SaurinDaniel Durocher @durocher1.bsky.social · 25/08/2026New work from the lab! We report that DDIAS is a downstream effector of CIP2A-TOPBP1 in mitosis that suppresses ssDNA to preserve genome integrity. From the great @yiboxue.bsky.social and many collaborators! Free link: authors.elsevier.com/a/1nfiF3vVUP... Pay link: www.cell.com/molecular-ce... 66218
Adrian Saurin @adesaurin.bsky.social · 28/05/2026I have a CRUK-funded postdoc position and a PhD student (UK only) to study senescence in cancer therapy. See details here: www.dundee.ac.uk/work-for-us/... www.findaphd.com/phds/project...dundee.ac.ukPostdoctoral Researcher - Genome Integrity - UOD2267Closing date: Friday 5 June 2026, 23:59 000
Adrian Saurin @adesaurin.bsky.social · 28/05/2026My vacancies for the Wellcome project are here: www.dundee.ac.uk/work-for-us/... www.dundee.ac.uk/work-for-us/... @andrea-musacchio.bsky.social has a postdoc vacancy here: www.mpg.de/26466895/pos... Tony Ly (Dundee) has a vacancy for a mass spec expert (to be advertised shortly)dundee.ac.ukPost-Doctoral Researcher - Genome IntegrityClosing date: Friday 5 June 2026, 23:59 112
Adrian Saurin @adesaurin.bsky.social · 28/05/2026Multiple postdoc/RA vacancies to work on the Wellcome-funded team project shown below. I also have vacancies to study senescence and to develop a chemical-genetic approach to inhibit specific cyclin/CDK complexes. See thread for details. DM or email me with any questions. 165
Reposted by Adrian SaurinHironori Funabiki @hirofunabiki.bsky.social · 09/04/2026Excited to share our structural insights into how microtubules differentially guide phosphorylation of kinetochore-microtubule regulators, Ndc80 and MCAK, for chromosome segregation. Heroic efforts by Yiming Niu with a fun collaboration with Jennifer DeLuca lab! www.science.org/doi/10.1126/...science.orgMicrotubules guide Aurora B substrate geometries for accurate chromosome segregationCryo-EM reveals how kinetochore-microtubule attachment is regulated by Aurora B substrate accessibility on microtubules. 32811
Adrian Saurin @adesaurin.bsky.social · 11/04/2026Congratulations! Looking forward to reading this 110
Reposted by Adrian SaurinNilsson lab @nilssonlab.bsky.social · 25/03/2026We finally managed to write Ikers master thesis project together. Interesting and careful work on FAM122A. www.biorxiv.org/content/10.6...biorxiv.org 052
Reposted by Adrian Saurinvagnarellilab.bsky.social @vagnarellilab.bsky.social · 19/03/2026www.sciencedirect.com/science/arti... 195
Adrian Saurin @adesaurin.bsky.social · 22/02/2026I have multiple positions available to join my lab from this summer: #postdoc, #student and #technician. Adverts to follow but see www.saurinlab.com for further details. #senescence, #mitosis, #cellcycle, #phosphorylation are the key areas. Email me if interested. 1129
Reposted by Adrian SaurinBertolin Lab @bertolinlab.bsky.social · 18/02/2026To kickstart this new Bluesky account: We're hiring! The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab. Details in the flyer — get in touch! 👇 23330
Reposted by Adrian SaurinMonica Bettencourt-Dias @monicabettencourt.bsky.social · 09/02/2026Last days to apply this position in our group! Do join us in this great Institute @crg.eu, with great colleagues, and help shaping the science and culture of our lab! 01010
Reposted by Adrian SaurinMatthew Freeman @mjafreeman.bsky.social · 03/02/2026I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee.. A few points and new information that bioscientists may find interesting... A 🧵 15150
Reposted by Adrian SaurinAndrea Musacchio @andrea-musacchio.bsky.social · 02/02/2026Two new papers from the lab published in The EMBO Journal! link.springer.com/article/10.1... By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading link.springer.com/article/10.1... By Arianna Esposito Verza and others – On mechanism of activation of PLK1 13915
Adrian Saurin @adesaurin.bsky.social · 02/02/2026@ukri.org Could you please make a statement about whether this will impact on grants already in review from autumn 2025? It's hard to accept grant opportunities closing, but even harder to accept the rug being pulled after review. Rumours of a 1-5% acceptance rate would be incredibly hard to take 121
Reposted by Adrian SaurinWendy Bickmore @wbickmor.bsky.social · 01/02/2026At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted. 23728
Adrian Saurin @adesaurin.bsky.social · 25/01/2026Wholeheartedly agree with this. Well said www.theguardian.com/commentisfre...theguardian.comBrooklyn Beckham and Prince Harry are the canaries in the coalmine. The children of Instagram will be next | Rhiannon Lucy CosslettA generation of overexposed children are being used by their parents for social media clout. What happens when they start to speak out, asks Guardian columnist Rhiannon Lucy Cosslett 010
Reposted by Adrian SaurinGlenn Masson @glennmasson.bsky.social · 21/01/2026Please share! We've an exciting one-year postdoctoral position available in my group - drug discovery using HDX-MS for a Parkinson's disease target. Join us on high-impact, translational research at the cutting edge of structural biology. We're a friendly bunch! www.dundee.ac.uk/work-for-us/...dundee.ac.ukPostdoctoral Research Assistant - UOD2127Closing date: Wednesday 18 February 2026, 23:59 043
Reposted by Adrian SaurinAlexis Barr @alexisbarr.bsky.social · 23/01/2026We are also recruiting a Postdoc in cell/molecular biology! 3yr, fully funded by @cancerresearchuk.org more details here: news.cancerresearchuk.org/2025/11/27/s... Apply here: www.imperial.ac.uk/jobs/search-...news.cancerresearchuk.orgSpin doctors: taking on the challenge of tissue-specific cell cycle control - Cancer Research UK - Cancer NewsA false start, a Nobel Prize and renewed hope – understanding cell cycle disruption over different tissues is complex. But we are getting there… 047
Reposted by Adrian SaurinHao Yin @haoyin.bsky.social · 11/01/2026Group-based Prediction System (GPS) 6.0 gps.biocuckoo.cn Online server for protein Post-Translational Modifications Kinase-specific phosphosite prediction across 185 species! >10 other PTMs #NucAcidRes 2023 academic.oup.com/nar/article/... 0148
Reposted by Adrian SaurinPMC Protein Modules Community @pmc-modularity.bsky.social · 07/01/2026We are back on Jan 19 at 3pm CET! Our first seminar for 2026 will feature Prof. Benjamin Turk (@benturklab.bsky.social) and Dr. Giorgia Massacci. Register to attend: tinyurl.com/PMCseminar2 Previous seminars: www.youtube.com/@PMCModularity 046
Adrian Saurin @adesaurin.bsky.social · 14/12/2025youtu.be/BFU1OCkhBwo?...youtu.beAI Expert: We Have 2 Years Before Everything Changes! We Need To Start Protesting! - Tristan HarrisYouTube video by The Diary Of A CEO 010
Adrian Saurin @adesaurin.bsky.social · 14/12/2025The best thing I’ve listened to all year. A brilliantly articulated vision about the dangers of AI which stresses the importance of societal pressure in demanding a safe future. Please consider listening and deciding for yourself if and how you can help open.spotify.com/episode/1S8F...podcasts.apple.comAI Expert: We Have 2 Years Before Everything Changes! We Need To Start Protesting! - Tristan HarrisPodcast Episode · The Diary Of A CEO with Steven Bartlett · 27/11/2025 · 2h 23m 110
Adrian Saurin @adesaurin.bsky.social · 08/12/20252 recent preprints show the mitotic stopwatch monitors more than just mitotic delays - it protects against WGD, cell enlargement and other stresses that mildly activate p53. It may act to amplify p53 signals to suppress tumourigenesis www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.6...biorxiv.orgThe mitotic stopwatch limits the proliferation of whole genome doubled cellsWhole genome doubling (WGD) is a frequent event in tumourigenesis that promotes chromosomal instability and tumour evolution. WGD is sensed indirectly due to the presence of extra centrosomes, which a... 0111
Reposted by Adrian SaurinFranz Meitinger @meitinger.bsky.social · 07/12/2025We’re recruiting a Postdoctoral Researcher at OIST (Okinawa, Japan) to explore how mitotic stress shapes aging. If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you. More info: www.oist.jp/careers/post... Website: www.oist.jp/research/res...oist.jpCell Proliferation and Gene Editing UnitEvery day, millions of cells divide to sustain essential tissue functions. Errors in this process can lead to developmental disorders or cancer. Our research focuses on the molecular mechanisms of cel... 026
Adrian Saurin @adesaurin.bsky.social · 01/11/2025I agree. And others offering ideas or help for work in progress would also be a step forward. We need to collaborate at the ideas stage much more and the internet could really help facilitate that. 010
Adrian Saurin @adesaurin.bsky.social · 26/10/2025Interesting. Looking forward to reading these…Congrats! 010
Reposted by Adrian SaurinAga Gambus @agagambus.bsky.social · 24/10/2025Last 3 days to apply for this post. Deadline 27/10/25 023
Reposted by Adrian SaurinNilsson lab @nilssonlab.bsky.social · 23/10/2025I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...candidate.hr-manager.netPhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR 01117
Adrian Saurin @adesaurin.bsky.social · 06/10/2025The model is based on the fact that paclitaxel binds strongly to microtubules. It could also be relevant for other cancer drugs that bind strongly to abundant cellular targets, such as microtubules or DNA 010
Adrian Saurin @adesaurin.bsky.social · 06/10/2025Seeing a loved one roll the dice with drugs like this (as too many of us will) really hits home how little we know. That was the inspiration to get this idea out. We must learn how these drugs work if we are going to improve on them 110
Adrian Saurin @adesaurin.bsky.social · 06/10/2025A simple idea for how paclitaxel achieves tumour selectivity: It is better retained inside dense tissue, allowing tumour levels to stay high even after it has cleared the healthy cells. A model that requires testing, but could be used to improve treatments if correct www.biorxiv.org/content/10.1...biorxiv.orgA perfusion-based model to explain how paclitaxel achieves tumour-selective killingPaclitaxel (taxol) is a commonly used chemotherapeutic that stabilizes microtubules to inhibit chromosome segregation during mitosis. Although it is used effectively to treat a wide variety of solid t... 160
Adrian Saurin @adesaurin.bsky.social · 02/10/2025 “We have economies that need to grow, whether or not they make us thrive; what we need are economies that make us thrive, whether or not they grow.” www.nature.com/articles/d41...nature.comEnd GDP mania: how the world should really measure prosperityThe obsession with economic output as a measure of human development puts sustainability on the back burner. Researchers can now help to devise better indicators. 010
Adrian Saurin @adesaurin.bsky.social · 01/10/2025Wow, a recruitment bonanza in the current climate? Magic!media.tenor.coma man in a plaid shirt sits in front of a couch with london written on itALT: a man in a plaid shirt sits in front of a couch with london written on it 020
Reposted by Adrian SaurinAlexis Barr @alexisbarr.bsky.social · 18/09/2025@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...imperial.ac.ukDescriptionPlease note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment... 03234
Reposted by Adrian SaurinMathew Garnett @mgarnett.bsky.social · 20/09/2025The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data! Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models. Start mining data now: dataminer.depmap.sanger.ac.uk 25623
Adrian Saurin @adesaurin.bsky.social · 19/09/2025Very excited to post our latest work showing the mitotic stopwatch monitors more than just mitotic delays - it protects against whole genome doubling and cell enlargement. Great work by fantastic postdocs Lindsey and Reece (& student Maria) #PostdocAppreciationWeek www.biorxiv.org/content/10.1...biorxiv.orgThe mitotic stopwatch limits the proliferation of whole genome doubled cellsWhole genome doubling (WGD) is a frequent event in tumourigenesis that promotes chromosomal instability and tumour evolution. WGD is sensed indirectly due to the presence of extra centrosomes, which a... 033
Reposted by Adrian SaurinEd Davey @eddavey.libdems.org.uk · 14/09/2025I've written to Keir Starmer, Kemi Badenoch and Nigel Farage, urging them to join me in condemning Elon Musk's dangerous remarks inciting violence yesterday. As leaders, we must stand together and make clear Musk will face serious consequences for these actions. 33569351857
Reposted by Adrian SaurinAndrew Blackford @andrewblackford.bsky.social · 10/09/2025Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...biorxiv.orgDDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosisDNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre... 23811
Reposted by Adrian SaurinJasmeen Oberoi @jasmeenoberoi.bsky.social · 09/09/2025🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia. 📅 Deadline: 29th September 2025. 🙏 Please share with anyone who might be interested.jobs.ac.ukResearch Technician – Protein Biochemistry at University of SussexExplore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities. 067
Reposted by Adrian SaurinDaniel Durocher @durocher1.bsky.social · 10/09/2025New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n www.biorxiv.org/content/10.1...biorxiv.orgMitotic single-stranded DNA suppression by DDIASIncomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde... 24917
Adrian Saurin @adesaurin.bsky.social · 03/09/2025Brilliant Alexis! Very pleased for you and very well deserved. 👏🍾 010
Reposted by Adrian SaurinHelfrid Hochegger @helfridh.bsky.social · 28/08/2025Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels. www.nature.com/articles/s41...nature.comThe balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells - Nature CommunicationsThe authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers… 3167
Reposted by Adrian SaurinElizabeth McKenna @elizsmckenna.bsky.social · 14/08/2025Now online in Cancer Discovery @aacrjournals.bsky.social: Integrative Proteogenomics & Forward Genetics Reveals a Novel Mitotic Vulnerability in TNBC - by Nicholas Neill, Shankha Satpathy, Trey Westbrook and colleagues doi.org/10.1158/2159... @bcmfromthelabs.bsky.social @broadinstitute.org 0114