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Louisa Hill

@louisa-hill.bsky.social
62 followers 95 following 2 posts

Chromosome biology and centromeres. PostDoc with Andrea Musacchio @MPI Dortmund, PhD @IMPvienna.

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Reposted by Louisa Hill
Max Haase @maxhaase.bsky.social · 18/02/2026
Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14
nature.com
Ancient co-option of LTR retrotransposons as yeast centromeres - Nature
Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...
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Reposted by Louisa Hill
The EMBO Journal @embojournal.org · 04/02/2026
What determines cell-cycle-dependent loading of human CENP-A? Bypassing the MIS18α/β scaffold via artificial M18BP1 dimerization allows @andrea-musacchio.bsky.social and coworkers to identify determinants, including structure of the M18BP1 SANTA domain link.springer.com/article/10.1...
link.springer.com
M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans - The EMBO Journal
The histone H3 variant CENP-A is considered an epigenetic landmark of centromeres. Its deposition reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The...
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Reposted by Louisa Hill
Andrea Musacchio @andrea-musacchio.bsky.social · 02/02/2026
Two new papers from the lab published in The EMBO Journal! link.springer.com/article/10.1... By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading link.springer.com/article/10.1... By Arianna Esposito Verza and others – On mechanism of activation of PLK1
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Louisa Hill @louisa-hill.bsky.social · 02/02/2026
It’s out! 🥳 Excited to share our new paper (with Kai Walstein, @andrea-musacchio.bsky.social and all others) on the role of M18BP1 in CENP-A loading! “M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans” link.springer.com/article/10.1...
link.springer.com
M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans - The EMBO Journal
The histone H3 variant CENP-A is considered an epigenetic landmark of centromeres. Its deposition reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The...
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Reposted by Louisa Hill
Lesly Calderón @lesly-calderon.bsky.social · 29/01/2026
Our manuscript "In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation" was just published in the @jem.org, @rupress.org!!!
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Reposted by Louisa Hill
The EMBO Journal @embojournal.org · 28/01/2026
Arianna Esposito Verza, @andrea-musacchio.bsky.social et al describe the long-sought-after mechanism of Bora dependency of PLK1 activation by Aurora A kinase during mitotic entry Another #RefereedPreprint ℅ @reviewcommons.org link.springer.com/article/10.1...
link.springer.com
Molecular requirements for PLK1 activation by T-loop phosphorylation - The EMBO Journal
Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...
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Reposted by Louisa Hill
IMP @impvienna.bsky.social · 29/01/2026
Plasma cells are the immune system’s antibody factories, and they originate from B-cells. Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:
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Reposted by Louisa Hill
IMP @impvienna.bsky.social · 10/11/2025
🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
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Reposted by Louisa Hill
Andrea Musacchio @andrea-musacchio.bsky.social · 31/07/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Molecular requirements for PLK1 activation by T-loop phosphorylation
Activation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T...
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Reposted by Louisa Hill
Duccio Conti @duccioconti.bsky.social · 16/07/2025
Finally out! Check out our new work on how M18BP1, known so far to be important for the epigenetic maintenance of centromeres, supports chromosome condensation when the cell enters mitosis. We also uncover a regulatory ménage á trois between condensin II, M18BP1 and MCPH1.
sciencedirect.com
Condensin II activation by M18BP1
Condensin I and II promote the drastic spatial rearrangement of the human genome upon mitotic entry. While condensin II is known to initiate this proc…
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Reposted by Louisa Hill
Andrea Musacchio @andrea-musacchio.bsky.social · 03/07/2025
www.sciencedirect.com/science/arti...
sciencedirect.com
Condensin II activation by M18BP1
Condensin I and II promote the drastic spatial rearrangement of the human genome upon mitotic entry. While condensin II is known to initiate this proc…
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Reposted by Louisa Hill
Andrea Musacchio @andrea-musacchio.bsky.social · 30/06/2025
www.biorxiv.org/content/10.1...
biorxiv.org
M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans
Deposition of CENP-A, the histone H3 variant considered an epigenetic landmark of centromeres, reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The lo...
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Reposted by Louisa Hill
IMP @impvienna.bsky.social · 08/05/2025
📢Open call: the International Birnstiel Award for Doctoral Research in Molecular Life Sciences is now accepting nominations! Do you know an outstanding PhD student who deserves recognition? Nominate them by 30 June 👉 www.imp.ac.at/achievements... 🎥 www.youtube.com/watch?v=ghfQ...
youtube.com
International Birnstiel Award for Doctoral Research in Molecular Life Sciences
YouTube video by Research Institute of Molecular Pathology
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Reposted by Louisa Hill
Max Haase @maxhaase.bsky.social · 25/04/2025
It’s out! The evolutionary origins of yeast point centromeres uncovered! “Ancient co-option of LTR retrotransposons as yeast centromeres” www.biorxiv.org/content/10.1...
biorxiv.org
Ancient co-option of LTR retrotransposons as yeast centromeres
The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...
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Reposted by Louisa Hill
Anton Goloborodko @golobor.bsky.social · 11/04/2025
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!! www.science.org/doi/10.1126/... A short clip describing the key results: www.youtube.com/watch?v=pmvO...
youtube.com
Rules of Engagement
YouTube video by Johan Gibcus
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Reposted by Louisa Hill
Journal of Cell Biology @jcb.org · 17/03/2025
Schweighofer, Mulay, @andrea-musacchio.bsky.social et al. reconstitute direct interactions between FAcilitates Chromatin Transcription and the 16-subunit constitutive centromere–associated network core of the chromatin-proximal #kinetochore rupress.org/jcb/article/... #mitosis
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Reposted by Louisa Hill
Francesca Maci @francescamaci.bsky.social · 07/02/2025
🌟🚨 Don't miss the opportunity to register! 🚨🌟
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Louisa Hill @louisa-hill.bsky.social · 28/01/2025
Congratulations on this well-deserved prize, Meinrad! An outstanding scientist and mentor! 👏 🥳
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Reposted by Louisa Hill
IMP @impvienna.bsky.social · 03/01/2025
We are diving into 2025 with how we finished 2024: with great research. The lab of Jan-Michael Peters discovered how #cohesin not only drives #chromatin architecture, but also links it to #epigenetics. Now in @embojournal.bsky.social: www.embopress.org/doi/full/10.... www.imp.ac.at/news/article...
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Reposted by Louisa Hill
Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 29/11/2024
The Vienna Biocenter Summer School 2025 call is now open for talented undergrads, it's a great prog. for students who are interested in the life sciences. training.vbc.ac.at/summer-school/ @impvienna.bsky.social @imbavienna.bsky.social @gmivienna.bsky.social @maxperutzlabs.bsky.social
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Reposted by Louisa Hill
IMP @impvienna.bsky.social · 19/11/2024
Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology? @IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-... Pls share!
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