Nature Reviews Immunology - Adaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen...

Pereira da Costa et al. define CXCR4 as a marker of dendritic cell activation in the steady state and in cancer, which is absent in activation elicited by Toll-like receptors or type I interferon rece...

Over 90 outstanding researchers from across the world have this year been elected to the Fellowship of the Royal Society, the UK’s national academy of sciences.

Castro-Dopico et al. report the design of reagents to bridge F-actin and Fcγ receptors, endowing a range of antigen-presenting cells with the ability to cross-present antigens from dead tumor cells an...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

The immune response to respiratory viruses in mice may hold the answers to inhibiting the spread of breast cancer.

Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?

It’s a world of bottom quarks and arsole compounds – so why is science still so serious? Levity can make it all a lot easier to understand, says science writer Helen Pilcher

Britain is preparing to cancel its contribution to one of the Large Hadron Collider's next major upgrades.

Serendipitous observations have shaped science for centuries. What happens to such discoveries when the academic atmosphere leaves no room for detours?

New data show that DNGR-1 enables type 1 conventional dendritic cells to sculpt cancer immunoediting through selective cross-presentation of F-actin-tethered neoantigens, enriching tumors for immune-e...

A natural experiment found that herpes zoster vaccination reduced the occurrence of mild cognitive impairment and deaths due to dementia, indicating that the vaccine may slow the progression of dement...

Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments

imageimageDNGR-1 (CLEC9A) is a C-type lectin receptor of type-1 conventional dendritic cells (cDC1s) with an important role in cross-presentation of dead cell antigens. This study explores how it equips cDC1s with the ability to cross-present such ...

Researchers find that virgin female mice can become aggressive towards pups when hungry, but only in certain hormonal states.

Edith Heard, the Crick’s new Director and CEO, shares ten lessons from a life in science, spanning curiosity, courage, coffee, and the secrets of our genetic code.