This study introduces MALVINA, a deep-learning platform that measures bacterial invasion and DNA damage in individual human cells, revealing how bacterial interactions and commonly used drugs reshape ...

Nature Communications is an open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, ...

The IAP antagonist ASTX660 has the potential to enhance cancer immunotherapy by sensitizing tumour cells to immune-mediated killing. Here, the authors report results from an open-label, multicentre ph...

ZNFX1 is an RNA helicase that plays a critical role in host defense against viral infections. Here, the authors reveal how RNA binding remodels autoinhibited ZNFX1 assemblies and activates the helicase for ATP-dependent RNA unwinding.

V-ATPases are proton pumps that acidify synaptic vesicles and intracellular compartments. Here, authors show that several inhibitors mainly switch individual brain V-ATPases into long-lived inactive states instead of slowing proton pumping rates.

Linking spatial context to molecular depth in tissue remains difficult. Here, the authors combine high-plex imaging, open-source image analysis and ultra-sensitive mass spectrometry to profile single endocrine cell types in human pancreatic islets, including rare bi-hormonal and polyhormonal states.

Nature Communications is an open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, ...

Authors present a deep learning model that recognises antibiotic modes of action (MoA) directly from brightfield images. Their proposed method complements traditional growth inhibition assays in the s...

In this study, the authors conduct a metagenomic study of 144 Aotearoa-New Zealand lakes to show that eutrophication impacts the functional redundancy of metabolic functions in surface sediment microbes, by narrowing of the species pool, although abundance shifts could offer some resilience.

In this study, the authors conduct a metagenomic study of 144 Aotearoa-New Zealand lakes to show that eutrophication impacts the functional redundancy of metabolic functions in surface sediment microbes, by narrowing of the species pool, although abundance shifts could offer some resilience.

In this study, the authors show that Prochlorococcus picocyanobacteria form biofilms and dynamically transition between free-living and attached states with significantly different physiology, thus suggesting a role for these bacteria in deep-ocean carbon export.

This study presents a comprehensive quantification of ocean heat content uncertainty since 1960 and shows a six-fold reduction in the global upper-2000m uncertainty in the last decade and a robust oce...

In this study, authors show that human gut microbiome composition and microbial genomes vary strongly across five industrialized countries, with diet microbiome links that are partly shared but largely population-specific.

There is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American bats, expanding knowledge of coronavirus diversity and features linked to zoonotic potential.

In this study, the authors show that Prochlorococcus picocyanobacteria form biofilms and dynamically transition between free-living and attached states with significantly different physiology, thus suggesting a role for these bacteria in deep-ocean carbon export.

This study shows that the extremity of globally synchronized seasonal warm events has sharply intensified in recent decades, reaching unprecedented levels since 850 CE, largely driven by anthropogenic...

A 3-D thermal model identifies a ~ 4.33 Ga temporal “sweet spot” for life’s origin, when decreased bombardment enabled mild hydrothermal niches to support RNA World chemistry and stable biomolecu...

In this study, authors show that human gut microbiome composition and microbial genomes vary strongly across five industrialized countries, with diet microbiome links that are partly shared but largely population-specific.

Chronic stress can promote hepatocellular carcinoma (HCC) progression. Here, the authors show in mice that chronic stress activates a brain-liver signaling circuit that mediates tumor epithelial-macro...

There is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American bats, expanding knowledge of coronavirus diversity and features linked to zoonotic potential.

There is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American ba...

Authors present a deep learning model that recognises antibiotic modes of action (MoA) directly from brightfield images. Their proposed method complements traditional growth inhibition assays in the search for novel antibiotics.

I am delighted to share that our article, “Glycerol metabolism triggers trypanosome differentiation into transmissible forms in mammalian tissue-like conditions,” has been selected by the editors of N...

In this study, authors investigate the evolution of bacterial resistance to antisense peptide nucleic acid (PNA) antibiotics. They observe that this typically occurs mainly by reducing drug uptake via mutations in the carrier peptide’s transporter, while resistance to a different carrier peptide stayed low and is easily bypassed by tweaking the drug sequence.

Addressing the debate about global warming acceleration, this study identifies key regions that underwent recent warming shifts. Results show that regional warming speed-ups vary in timing from the 19...

Single-cell proteomics can reveal cellular heterogeneity but remains challenging for small cells. Here, the authors establish a sensitive label-free workflow that quantifies up to 7,000 proteins per HeLa cell and up to 4,000 proteins in small human immune cells.

Proteasomes can be capped by regulatory particles other than the 19S complex, but how these form is unclear. Here, authors reveal cryo-EM structures of Blm10-proteasome assembly intermediates and provide evidence for parallel assembly pathways.

Ion channels of the LRRC8 family are modular proteins consisting of a transmembrane pore and cytoplasmic regulatory domains. Here the authors combine structural and functional data to define the role of the intracellular sub-domain (ISD) of the obligatory LRRC8A subunit for channel activation.

Members of the LRRC8 family form heteromeric ion channels that are activated upon cell swelling. Here authors describe the architecture of assemblies of LRRC8A and D subunits and their conformational changes during activation.

AMPA receptors mediate the majority of excitatory neurotransmission. Here, the authors report structural and functional regulation of GluA2 AMPA receptor by inhibitory auxiliary subunits GSG1L and TARP γ5 and by epilepsy-associated disease mutations.

In this study, the authors show that during the 2022 avian influenza outbreak, Sandwich tern mortality rose sharply with age: over 40% of the oldest birds died versus 5–10% of young breeders, likely removing experienced individuals and potentially weakening population resilience.

This Swedish population study reveals that healthy vaccinee bias inflates estimates of the effectiveness of updated COVID-19 vaccines in adults aged 65 years or older, highlighting the need to account for frailty and overall health status.

In this study, the authors show that marine eukaryotic phytoplankton widely take up the sulfur compound DMSP via the BCCT family transporter PaDT, suggesting an energy-saving strategy in some taxa and a dual role for phytoplankton as both a source and a sink in organosulfur cycling.

A lab-grown micro bladder may explain why urinary tract infections (UTIs) return so frequently, according to a study by researchers at UCL, the University of Oxford and the University of Leicester.

How bacteria develop resistance to antisense antibiotics - and how future therapies can be designed to reduce the risk of resistance

In this study, the authors show that during the 2022 avian influenza outbreak, Sandwich tern mortality rose sharply with age: over 40% of the oldest birds died versus 5–10% of young breeders, likely removing experienced individuals and potentially weakening population resilience.

A lab-grown micro bladder may explain why urinary tract infections (UTIs) return so frequently, according to a study by researchers at UCL, the University of Oxford and the University of Leicester.

Maset et al. show that bladder conditions strongly influence how urinary tract infections respond to antibiotics and bacteriophages, highlighting the need for more realistic lab models to improve diag...

In this study, the authors show that marine eukaryotic phytoplankton widely take up the sulfur compound DMSP via the BCCT family transporter PaDT, suggesting an energy-saving strategy in some taxa and a dual role for phytoplankton as both a source and a sink in organosulfur cycling.

Authors present a deep learning model that recognises antibiotic modes of action (MoA) directly from brightfield images. Their proposed method complements traditional growth inhibition assays in the search for novel antibiotics.