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Kosuke Takada

@kosuke-takada.bsky.social
52 followers 28 following 7 posts

Virologist in Eddie’s group @ USYD | Virology | Evolution

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Kosuke Takada @kosuke-takada.bsky.social · 05/09/2026
We’re delighted to share that our paper on a highly divergent betacoronavirus from a South American bat that encodes a functional furin cleavage site is now published. 🦇🦠 Another fascinating reminder of the remarkable diversity of coronavirus evolution in wildlife. 🔗 doi.org/10.1038/s414...
doi.org
A divergent betacoronavirus with a functional furin cleavage site in South American bats - Nature Communications
There is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American ba...
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Bloom lab @jbloomlab.bsky.social · 23/07/2026
In new study led by @bdadonaite.bsky.social, we show many influenza HAs (H5, H7, H9, H1, H2, H3) can use avian or human MHC-II to enter cells. We then use novel combo of deep mutational scanning & cryoEM to define how H5 HA binds to avian MHC-II. Preprint: doi.org/10.64898/202...
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Michelle Wille @duckswabber.bsky.social · 19/06/2026
Suspected detection of H5 strain of bird flu in WA, which would be first in Australia www.abc.net.au/news/2026-06...
abc.net.au
Suspected H5 bird flu detected in Australia
A wild migratory bird in Western Australia has returned a suspected positive result for avian influenza, which has devastated populations of seabirds, seals and other animals across the world.
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@WildImmunity @wildimmunity.bsky.social · 18/04/2026
Our Wild Immunology team is looking for a new research veterinarian. The project will involve 5-7 day field trapping trips a few times per year and assisting with caring for animals during vaccine trials with captive and wild devils. careers.utas.edu.au/cw/en/job/50... Please repost
careers.utas.edu.au
Current Vacancies
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ASM @asm.org · 26/02/2026
In a guinea pig model, H5N1 replicated in the nose, trachea and lungs when delivered intranasally, by aerosol or by transmission. In contrast, H3N2 stayed mostly in the nose, suggesting mode of exposure modulates within-host spatial dynamics. #JVirology: asm.social/2PE
Barcode diversity is maintained in the URT but declines with increased distance from and branching of the main airways.
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Kosuke Takada @kosuke-takada.bsky.social · 22/02/2026
Our discovery of novel viruses in invasive camelids in Australia leads us to propose a simple idea: RNA viruses may repeatedly evolve functional modules at the 5′ end of their genomes. #Virology #RNAvirus #VirusEvolution #Picornavirus #VirusDiscovery doi.org/10.64898/202...
doi.org
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Michelle Wille @duckswabber.bsky.social · 18/01/2026
Extremely interesting paper - HA subtypes have wildly different sequences, but share structure and function. Deep mutations scanning of H3, H5, H7: ~50% of HA sites have very diverged preferences for different amino acids 👉 www.biorxiv.org/content/10.6...
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Nature @nature.com · 06/11/2025
Nature research paper: Assessing phylogenetic confidence at pandemic scales go.nature.com/3WZMsaV
go.nature.com
Assessing phylogenetic confidence at pandemic scales - Nature
A method using subtree pruning and regrafting-based tree assessment (SPRTA), which considers evolutionary relationships between lineages, enhances interpretability of phylogenetic analyses such as those of SARS-CoV-2 variants.
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Kosuke Takada @kosuke-takada.bsky.social · 27/10/2025
We’ve identified a highly divergent betacoronavirus from South American bat that encodes a functional furin cleavage site. Another fascinating reminder of how diverse coronavirus evolution is in wildlife reservoirs. #Virology #VirusEvolution #Bats #Coronavirus www.biorxiv.org/content/10.1...
biorxiv.org
A divergent betacoronavirus with a functional furin cleavage site in South American bats
Bats are natural reservoirs for a wide range of RNA viruses. Members of the genus Betacoronavirus, including Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome...
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Reposted by Kosuke Takada
Jon Mifsud @jonathonmifsud.bsky.social · 25/08/2025
There’s been a bunch of new approaches looking at deep viral evolutionary history. We’ve put together a mini review highlighting some recent advancements in structural phylogenetics and time-dependent rate models and what they could do for the field 🦠 🔗 journals.asm.org/doi/full/10....
journals.asm.org
Recent advances in the inference of deep viral evolutionary history | Journal of Virology
Phylogenetic studies examining the origins, emergence, and spread of viruses have arguably been one of the most active and successful areas of evolutionary biology and form the bedrock of the flourishing field of genomic epidemiology. This, in part, reflects the ability of viruses, particularly those with RNA genomes, to evolve at rates much greater than their cellular counterparts (1). The rapid rate at which viruses evolve and accumulate mutations enables evolutionary signals to be identified through comparative genomics at short timescales relevant for outbreak investigation and response. The integration of phylogenetics and epidemiology, known as phylodynamics, has become a vital tool in response to numerous viral outbreaks, epidemics, and pandemics, including Ebola (2), Zika (3), and, more recently, COVID-19 (4) and mpox (5).
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Erin Harvey @erinharvey.bsky.social · 27/06/2025
I’m so excited to finally have this work published. Fantastic work from @julienmelade.bsky.social culturing a virus identified through metagenomic virus discovery methods
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Kosuke Takada @kosuke-takada.bsky.social · 23/05/2025
Luthfi did great work on H1N1pdm influenza viruses (isolate strains in 2016–2019)—proud to support his research! www.nature.com/articles/s44...
nature.com
Characterization of A(H1N1)pdm09 influenza viruses isolated between 2016 and 2019 - npj Viruses
npj Viruses - Characterization of A(H1N1)pdm09 influenza viruses isolated between 2016 and 2019
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Michelle Wille @duckswabber.bsky.social · 22/05/2025
Excellent, epic review of HPAI H5N1! 👉 www.nature.com/articles/s41...
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Michelle Wille @duckswabber.bsky.social · 12/05/2025
Rhys and I found some weird influenza B viruses in fish a few years ago. For 2, the HA's bind a2,3 sialic acid ("bird type receptor"). The Siamese algae eater virus NA has a highly conserved structure and active site. No cross-reactive antibodies in human sera. 👉 biorxiv.org/content/10.1...
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Eddie Holmes @eddieholmes.bsky.social · 09/04/2025
Recombination between positive-sense and negative-sense RNA viruses: journals.plos.org/plospathogen...
journals.plos.org
A positive-sense single-stranded RNA virus acquired a negative-sense open reading frame through recombination
Author summary The discovery of brine shrimp virga-like virus 1 (BSVV1) challenges the conventional view that positive- and negative-sense RNA viruses are evolutionarily independent. Through genomic a...
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Michelle Wille @duckswabber.bsky.social · 06/01/2025
chimeric RdRps with PB1 genes from the 1918/1957/1968 pandemic IAVs in H2N1 LPAI backgrounds: 🔻 polymerase activity, virulence, and altered lung pathology vs native LPAI PB1 w 🔺 pathogenicity and polymerase activity in cells and mice. 👉 www.science.org/doi/full/10....
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