Sign in

MRC National Mouse Genetics Network

@mrcmousenetwork.bsky.social
215 followers 136 following 101 posts

Distributed challenge-led research clusters working with the Mary Lyon Centre at MRC Harwell to accelerate understanding of human disease using #MouseModels

PostsRepliesMedia
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 07/09/2026
Recent work from the Degron Tagging Cluster Wood laboratory addresses an important question in the targeted protein degradation field: does the mechanism by which an oncogene become overactive influence how effectively the target protein can be eliminated? nmgn.mrc.ukri.org/news/how-can...
nmgn.mrc.ukri.org
How cancer genes are activated shapes the effectiveness of next-generation protein-degrading drugs | National Mouse Genetics Network
A new study from the Degron Tagging Cluster Wood laboratory at the University of Edinburgh addresses an important but underexplored question in the targeted protein degradation field: does the mechani...
010
Reposted by MRC National Mouse Genetics Network
Mary Lyon Centre at MRC Harwell @mrcharwell.bsky.social · 11/06/2026
Many congratulations to Lizzy Fisher, a former PhD student and later Programme Leader at MRC Harwell, who was recently elected a Fellow of the Royal Society
har.mrc.ac.uk
Elizabeth Fisher elected a Fellow of the Royal Society | Mary Lyon Centre
"The people I’ve worked with at Harwell have had a huge part in shaping my career, so this is for you too.”
034
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 12/05/2026
Excited to share our newly published editorial article in @dmmjournal.bsky.social As discussions on animal research and alternative methods evolve we wanted to contribute a balanced, evidence-led perspective on the future of preclinical research. journals.biologists.com/dmm/article/...
cob.silverchair-cdn.com
042
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 07/05/2026
Excited to share results from the first Business Engagement Fund from the MRC, supporting #academia-#industry collaboration. Work from Nick Greene and Outfox Bio shows LNP-mRNA delivery works effectively in an NKH mouse model—proof of concept for therapeutic mRNA. nmgn.mrc.ukri.org/news/a-busin...
nmgn.mrc.ukri.org
A Business Engagement Fund project to test Lipid Nanoparticle (LNP)-mediated mRNA delivery and efficacy | National Mouse Genetics Network
The Medical Research Council provided £750K in funding for the National Mouse Genetics Network’s Business Engagement Fund with a call for applications in early 2023. The Business Engagement Fund suppo...
063
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 15/04/2026
If you're not a subscriber, you will have just missed our Spring 2026 Newsletter, but don't worry - you can find it here and click subscribe to make sure you don't miss out next time! mailchi.mp/637ad22cdcdb...
mailchi.mp
National Mouse Genetics Network Spring 2026 Newsletter
010
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 26/03/2026
Back in November, our Horizon Scanning Working Group held its second workshop designed to build a UK community around the latest advances in genome engineering technologies: nmgn.mrc.ukri.org/news/horizon...
nmgn.mrc.ukri.org
Horizon Scanning Working Group genome engineering workshop | National Mouse Genetics Network
On the 26th and 27th of November, the Network’s Horizon Scanning Working Group held its second workshop designed to build a UK community around the latest advances in genome engineering technologies. ...
011
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 23/03/2026
Stealth BioTherapeutics has today announced an award from our Business Engagement Fund to support a new collaboration to evaluate the effects of their compound SBT-589 on biomarkers of disease in a mouse model of Leigh syndrome, a rare mitochondrial disorder: nmgn.mrc.ukri.org/news/busines...
nmgn.mrc.ukri.org
Business Engagement Fund award to support mitochondrial disease research | National Mouse Genetics Network
Stealth BioTherapeutics, a commercial-stage biotechnology company focused on the discovery, development, and commercialisation of novel therapies for diseases involving mitochondrial dysfunction, have...
022
Reposted by MRC National Mouse Genetics Network
London Mitochondrial Centre @londonmito.bsky.social · 18/03/2026
Clinicians and researchers with an interest in #mitochondrial disease: Queen Square Advances in Mitochondrial Medicine (5 May 2026) is a CPD-approved course covering pre-clinical & translational research, and the latest updates in NHS diagnostic testing. Registration: www.ucl.ac.uk/brain-scienc...
ucl.ac.uk
Queen Square Advances in Mitochondrial Medicine 2026
The London Mitochondrial Centre is hosting a one-day symposium.
135
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 19/03/2026
Earlier this month we held a hugely successful hackathon focused on the spatial analysis software MuSpAn to conduct a deep dive study on the progression of liver metastases from colorectal cancer. Read more: nmgn.mrc.ukri.org/news/muspan-...
nmgn.mrc.ukri.org
MuSpAn hackathon – Team Science in Action! | National Mouse Genetics Network
The MRC National Mouse Genetics Network (NMGN) celebrated a hugely successful hackathon two weeks ago (2nd-6th March), focused on the spatial analysis software MuSpAn, a tool for the analysis of […]
010
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 12/02/2026
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of #MeetTheExpert posts features Owen Sansom, whose group has created advanced mouse models matching a variety of human colorectal cancer subtypes. nmgn.mrc.ukri.org/working-grou...
011
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 10/02/2026
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of #MeetTheExpert posts features Laura Greaves, whose group investigates the role of age-related mitochondrial DNA mutations in cancer biology nmgn.mrc.ukri.org/working-grou...
064
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 04/02/2026
MAPK-driven epithelial cell plasticity underlies colorectal cancer therapeutic resistance: Members of our Cancer Cluster contributed to a recent paper that provides insight into resistance to therapy and suggests strategies that may improve therapeutic efficacy nmgn.mrc.ukri.org/news/mapk-dr...
nmgn.mrc.ukri.org
MAPK-driven epithelial cell plasticity underlies CRC therapeutic resistance | National Mouse Genetics Network
(White et al., Cancer Research UK Scotland Institute and collaborators across the MRC National Mouse Genetics Network – Cancer Cluster) Colorectal cancer (CRC) is a genetically complex disease, yet re...
132
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 04/02/2026
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Prof Robin Williams, whose group uses Dictyostelium to identify the proteins targeted by drugs nmgn.mrc.ukri.org/working-grou...
010
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 02/02/2026
Fresh insights reveal how cancer gene mutations drive tumour growth: Andrew Wood (lead of our Degron Cluster) has co-led a team that created a comprehensive map that shows how hundreds of possible mutations in a key cancer gene influence tumour growth nmgn.mrc.ukri.org/news/fresh-i...
nmgn.mrc.ukri.org
Fresh insights reveal how cancer gene mutations drive tumour growth | National Mouse Genetics Network
Scientists have created a comprehensive map showing how hundreds of possible mutations in a key cancer gene influence tumour growth, offering a new insight that could guide the development of […]
022
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 30/01/2026
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series highlighting our diverse expertise features Dr Andrew Wood, whose lab uses genome editing and targeted protein degradation to study genetic disease using cell lines, organoids, and mice.
065
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 27/01/2026
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases. nmgn.mrc.ukri.org/working-grou...
042
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 21/01/2026
The MRC National Mouse Genetics Network’s Best Models Working Group connects researchers with the right expertise in biological models and computational tools as part of our commitment to the #3Rs. nmgn.mrc.ukri.org/working-grou... #MeetTheExpert
012
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 20/01/2026
A study led by Owen Sansom, Director of the National Mouse Genetics Network, has identified the protein NPM1 as a potential therapeutic target in liver and bowel cancers: www.bbc.co.uk/news/article...
bbc.co.uk
Scientists discover potential new treatment to tackle cancer
The research focused on the genetic faults that allow the disease to hijack a signalling system in the body.
120
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 13/01/2026
The National Mouse Genetics Network has contributed to a new briefing from the UK Parliamentary Office of Science and Technology (POST) that examines the development and use of emerging technologies as alternatives to animals in life sciences research. nmgn.mrc.ukri.org/news/mary-ly...
nmgn.mrc.ukri.org
Mary Lyon Centre and National Mouse Genetics Network contribute to Parliamentary report on research models | National Mouse Genetics Network
The UK Parliamentary Office of Science and Technology (POST) has published a new briefing examining the development and use of emerging technologies as alternatives to animals in life sciences researc...
031
Reposted by MRC National Mouse Genetics Network
Prof Anthony Isles @profantisles.bsky.social · 08/01/2026
10 days left to apply for this position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social 🧠🧬🐭
003
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 10/01/2026
Still time to apply to join this incredible team and contribute to our understanding of neurodevelopmental disorders. #PreclinicalResearch #Genetics
010
Reposted by MRC National Mouse Genetics Network
Prof Anthony Isles @profantisles.bsky.social · 19/12/2025
📢 Job Alert 📢 Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭 Please repost! www.jobs.ac.uk/job/DPW471/s...
jobs.ac.uk
Senior Research Associate at Lancaster University
An opportunity for an academic position as a Senior Research Associate is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
035
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 20/11/2025
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Dr Alex Benedetto, a Senior Lecturer in Integrative Physiology, who works with C. elegans. nmgn.mrc.ukri.org/working-grou...
010
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 18/11/2025
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Prof Karen Liu, who works on congenital anomalies arising during embryonic development. nmgn.mrc.ukri.org/working-grou...
031
Reposted by MRC National Mouse Genetics Network
Prof Anthony Isles @profantisles.bsky.social · 14/11/2025
Great talk by Claire and Rosie this afternoon @mrcmousenetwork.bsky.social meeting! 🧠🧠🧠🧠
081
Reposted by MRC National Mouse Genetics Network
MRC MitoCluster @mrcmitocluster.bsky.social · 14/11/2025
Great two days in York with the MRC National Mouse Genetics Network. Always a pleasure to be invited to share MitoCluster's work, thank you! @mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social
064
Reposted by MRC National Mouse Genetics Network
Mill_lab @cilialab.bsky.social · 14/11/2025
Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies
0122
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 12/11/2025
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.
nmgn.mrc.ukri.org
Meet the Experts | National Mouse Genetics Network
We connect researchers with specialists in diverse model systems to support innovation and refinement.
010
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 12/11/2025
We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.
130
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 06/11/2025
Our Best Models Working Group can offer advice on the use of a range of model systems. Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.
021
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 04/11/2025
Our Best Models Working Group can offer advice on the use of a range of model systems. Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology. #MeetTheExpert
021
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 31/10/2025
If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools: nmgn.mrc.ukri.org/working-grou... #MeetTheExpert #3Rs
nmgn.mrc.ukri.org
Meet the Experts | National Mouse Genetics Network
We connect researchers with specialists in diverse model systems to support innovation and refinement.
003
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 09/10/2025
Nice place for a bit of work and hopefully some fun!
020
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 25/09/2025
Last session in full swing! #OrganoidsAreUs2025
021
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 25/09/2025
Our first session of today's #OrganoidsAreUs2025 is dedicated to organoid models in cancer research. We go with ✨ Vincenzo Corbo ✨ Ben Dwyer ✨ Maximilian Reichert ✨ Chiara Braconi Another packed session for a critical and fast-developing field!
052
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 24/09/2025
Second session on #StemCells #regeneration and #cancer. We start with 🧪 Phil Jones from the @sangerinstitute.bsky.social 🧪 Followed by Suet Yu Leung from Hong Kong Uni and 🧪 Eleanor Earp from @edinburghuni.bsky.social , ✨ First keynote lecture by Helmuth Gehart from @ethz.ch #OrganoidsAreUs2025
022
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 24/09/2025
A day dedicated to #StemCells #regeneration and #cancer. 1st session sponsored by TECAN with Nick Barker from A*STAR, Amian Barai from @univ-amu.fr and our first Tony Burgess Orator, Vivian Li from @crick.ac.uk, providing a fascinating insight into this fast-developing area #OrganoidsAreUs2025
011
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 23/09/2025
Opening session sponsored by @stemcell.com and OLS with a welcome from Director Owen Sansom @cruk-si.bsky.social and Elizabeth Vincan @unimelb.bsky.social . Our plenary speaker Prof Hans Clevers from @utrechtuniversity.bsky.social talks about human epithelial organoids. #OrganoidsAreUs2025
043
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 23/09/2025
We are ready to go at the CRUK Scotland Institute, @cruk-si.bsky.social, for this exciting meeting, bringing together a huge wealth of new technologies and scientific advances. First session this afternoon. Watch this space! #OrganoidsAreUs2025
032
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 16/09/2025
On 14th November, we are once again holding our Network Science Day in York, which is an exciting opportunity for Network members and non-members to engage and develop new collaborations! The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.
033
Reposted by MRC National Mouse Genetics Network
The Francis Crick Institute @crick.ac.uk · 22/08/2025
If you lead a facility or research group whose primary focus is on genetic engineering, our upcoming workshop held on behalf of the @mrcmousenetwork.bsky.social may be for you. Find out more and apply ⬇️ www.crick.ac.uk/whats-on/uk-...
crick.ac.uk
UK facilities workshop on genome engineering technologies
122
Reposted by MRC National Mouse Genetics Network
Andrew Wood @andrewwood.bsky.social · 26/08/2025
Nice write up on the @mrcmousenetwork.bsky.social website, highlighting the awesome work of first author Gillian Taylor, is available here: nmgn.mrc.ukri.org/news/underst...
nmgn.mrc.ukri.org
Understanding the Protein Tagging Problem: A New Study from the NMGN Degron Tagging Cluster | National Mouse Genetics Network
Celebrating Research Specialists: Driving Innovation in Mouse Genetics Research specialists are often the unsung heroes in biomedical research groups, providing continuity in long-term research progra...
051
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 13/08/2025
Claus Nerlov, from the @imm.ox.ac.uk and Haem Cluster member, was awarded a @wellcometrust.bsky.social Discovery Award to map the regulatory networks in blood cell production. This will provide invaluable insight for the development of better therapies for patients nmgn.mrc.ukri.org/news/wellcom...
nmgn.mrc.ukri.org
Wellcome Discovery Award for Claus Nerlov of the Heam Cluster | National Mouse Genetics Network
Claus Nerlov, Professor of Stem Cell Biology and member of our Haem Cluster, has been awarded funding from Wellcome to map the gene regulatory networks in blood cell production and […]
041
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 11/08/2025
A workshop about data science and DeepLabCut organised with our colleagues of the University of York and Generation Research. Check out our story about it! nmgn.mrc.ukri.org/news/a-works...
nmgn.mrc.ukri.org
A workshop for behavioural scientists on the use of DeepLabCut | National Mouse Genetics Network
As part of the effort to disseminate knowledge and skills across the Network and the community, we asked some of our GenerationResearch colleagues at the University of York to organise […]
000
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 05/08/2025
Proud to share an exciting study on the metabolic changes observed in the body before the spread of breast cancer. This seminal work could pave the way for early interventions and more positive outcomes for patients. Congratulations to all involved! www.embopress.org/doi/full/10....
embopress.org
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...
111
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 17/07/2025
Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease. 📆23 - 26 September 2025 📍Glasgow, Scotland Early bird registration extended to 18th July. Register below! 👇 www.crukscotlandinstitute.ac.uk/events/organ...
crukscotlandinstitute.ac.uk
Organoids Are Us 2025
Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk
021
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 08/07/2025
Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease. 📆23 - 26 September 2025 📍Glasgow, Scotland Early bird registration extended to 18th July. Register below! 👇 www.crukscotlandinstitute.ac.uk/events/organ...
crukscotlandinstitute.ac.uk
Organoids Are Us 2025
Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk
051
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 01/07/2025
Interested in staying current with the latest applications and discoveries using #organoids? Subscribe to Organoid News by STEMCELL Science News to stay on top of the latest publications, reviews, industry news, and more. www.stemcellsciencenews.com/organoid-new...
stemcellsciencenews.com
Organoid News | Science News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
021
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 27/06/2025
Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease. 📆23 - 26 September 2025 📍Glasgow, Scotland Early bird registration extended to 18th July. Register below! 👇
crukscotlandinstitute.ac.uk
Organoids Are Us 2025
Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk
033
Reposted by MRC National Mouse Genetics Network
MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 24/06/2025
A great example of the Network’s fundamental contributions to our understanding of the biological consequences of molecular manipulation and the benefits of cross cluster #collaborations. Lastly, but not in order of importance, another Network #ECR shining here! Well done Gillian Taylor!
032