A collaborative research programme led by the Institute of Genetics and Cancer has been awarded £1.92 million from the Advanced Research + Invention Agency (ARIA).

Gudauskaitė et al. show that the mechanism driving oncogenic protein overexpression influences the effectiveness of targeted protein degradation. While stabilizing mutations do not limit protein depletion, increased protein production limits how far degraders can reduce target levels, with implications for cancer therapy and drug resistance.

The way cancer-causing proteins accumulate in tumours may influence how effectively a promising new generation of medicines can remove them, a study has found.

Gudauskaitė et al. show that the mechanism driving oncogenic protein overexpression influences the effectiveness of targeted protein degradation. While stabilizing mutations do not limit protein deple...

Tong et al. describe a chemical genetic system to evaluate the degradability of deubiquitylase (DUBs) enzymes by PROTACs that do not inhibit their catalytic activity. They find that some Dubs are readily degradable, others resist degradation through auto-deubiquitylation, and some are inherently poor proteasome substrates because they are difficult to unfold.

Scientists have created a complete map showing how hundreds of possible mutations in a key cancer gene influence tumour growth.

In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...

Author summary To better understand the function of specific proteins, researchers need ways to quantify their abundance, to visualise their movements, to understand what other molecules they interact...

The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.

Computational methods for assessing the likely impacts of mutations, known as variant effect predictors (VEPs), are widely used in the assessment and interpretation of human genetic variation, as well...

Halda Therapeutics has started a clinical trial of its first-in-modality RIPTAC drug HLD-0915 in prostate cancer, to see if bifunctional drugs can provide tissue-specific activity.

ABSTRACT. Developmental biologists can perform studies that describe a phenomenon (descriptive work) and/or explain how the phenomenon works (mechanistic work). There is a prevalent perception that mo...

The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...

Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...