iiinova — where your digital self keeps evolving

MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 12/02/2026

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of #MeetTheExpert posts features Owen Sansom, whose group has created advanced mouse models matching a variety of human colorectal cancer subtypes. nmgn.mrc.ukri.org/working-grou...

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 10/02/2026

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of #MeetTheExpert posts features Laura Greaves, whose group investigates the role of age-related mitochondrial DNA mutations in cancer biology nmgn.mrc.ukri.org/working-grou...

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 04/02/2026

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Prof Robin Williams, whose group uses Dictyostelium to identify the proteins targeted by drugs nmgn.mrc.ukri.org/working-grou...

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 30/01/2026

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series highlighting our diverse expertise features Dr Andrew Wood, whose lab uses genome editing and targeted protein degradation to study genetic disease using cell lines, organoids, and mice.

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 27/01/2026

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases. nmgn.mrc.ukri.org/working-grou...

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 21/01/2026

The MRC National Mouse Genetics Network’s Best Models Working Group connects researchers with the right expertise in biological models and computational tools as part of our commitment to the #3Rs. nmgn.mrc.ukri.org/working-grou... #MeetTheExpert

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 20/11/2025

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Dr Alex Benedetto, a Senior Lecturer in Integrative Physiology, who works with C. elegans. nmgn.mrc.ukri.org/working-grou...

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 18/11/2025

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Prof Karen Liu, who works on congenital anomalies arising during embryonic development. nmgn.mrc.ukri.org/working-grou...

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 06/11/2025

Our Best Models Working Group can offer advice on the use of a range of model systems. Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 04/11/2025

Our Best Models Working Group can offer advice on the use of a range of model systems. Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology. #MeetTheExpert

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 25/09/2025

Our first session of today's #OrganoidsAreUs2025 is dedicated to organoid models in cancer research. We go with ✨ Vincenzo Corbo ✨ Ben Dwyer ✨ Maximilian Reichert ✨ Chiara Braconi Another packed session for a critical and fast-developing field!

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 24/09/2025

Second session on #StemCells #regeneration and #cancer. We start with 🧪 Phil Jones from the @sangerinstitute.bsky.social 🧪 Followed by Suet Yu Leung from Hong Kong Uni and 🧪 Eleanor Earp from @edinburghuni.bsky.social , ✨ First keynote lecture by Helmuth Gehart from @ethz.ch #OrganoidsAreUs2025

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 24/09/2025

A day dedicated to #StemCells #regeneration and #cancer. 1st session sponsored by TECAN with Nick Barker from A*STAR, Amian Barai from @univ-amu.fr and our first Tony Burgess Orator, Vivian Li from @crick.ac.uk, providing a fascinating insight into this fast-developing area #OrganoidsAreUs2025

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 23/09/2025

Opening session sponsored by @stemcell.com and OLS with a welcome from Director Owen Sansom @cruk-si.bsky.social and Elizabeth Vincan @unimelb.bsky.social . Our plenary speaker Prof Hans Clevers from @utrechtuniversity.bsky.social talks about human epithelial organoids. #OrganoidsAreUs2025

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 23/09/2025

We are ready to go at the CRUK Scotland Institute, @cruk-si.bsky.social, for this exciting meeting, bringing together a huge wealth of new technologies and scientific advances. First session this afternoon. Watch this space! #OrganoidsAreUs2025

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 16/09/2025

On 14th November, we are once again holding our Network Science Day in York, which is an exciting opportunity for Network members and non-members to engage and develop new collaborations! The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 10/06/2025

Sid took his work forward and independently drove the development of a computational tool (dualGSEA) that enables statistical and biological analysis of gene expression data to facilitate a more nuanced interpretation of transcriptomic info and contribute to the identification of therapeutic targets

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 10/06/2025

In early 2024, Sid’s work resulted in a new way to classify tumours based on biological pathways rather than individual gene expression. This allowed the identification of a slow cycling phenotype (PSD3) that spanned two of the CMSs and resulted in poor outcomes despite a less aggressive appearance.

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 10/06/2025

In 2023, Sid was involved with the challenge of aligning genetically engineered mouse models with the consensus molecular subtypes (CMS1-4) of human colorectal cancers, developing the MmCMS classifier to more accurately match mouse models with human cancers and improve translatability.

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 19/05/2025

And India and Avery talking about #microbiome and #inflammation. The Gut Florist on great form!

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 19/05/2025

Sponsoring #Pint25 at a packed @oxfordblue.bsky.social and our own @rsbains.bsky.social going through the journey to passive behaviour monitoring powered by #AI @mrcharwell.bsky.social

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 10/04/2025

#Glasgow gave us the most amazing welcome for #IMGCGlasgow! The sun shone for the whole time and we felt hugely welcome. The science was exciting, new and old friends were met, possibilities opened up and we look forward to meeting again soon! Thanks everyone! #MouseGenetics #PreclinicalResearch

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 09/04/2025

Martin Hrabě de Angelis is giving this year’s Snell lecture. His work with @impc-phenotypes.bsky.social and Infrafrontier and long standing collaboration with the @mrcharwell.bsky.social makes him a great friend! Congratulations! #IMGCGlasgow

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 09/04/2025

Paula Clark from the @mrclmb.bsky.social and the Haem Cluster talking about generating a good mouse model to study immune cell function #IMGCGlasgow

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 09/04/2025

There was some Network fun as well as we gathered for a lovely dinner and relaxation evening. Nothing beats a chat with some good food and a drink! #WorkIsFun

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 09/04/2025

Not a network talk but we really enjoyed this one by @davidashbrook.bsky.social on transgenic models of Alzheimer’s Disease on different genetic backgrounds. Loads of data and incredible imaging!

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 08/04/2025

And finally Claus Nerlow form the Haem Cluster describing models of acute leukaemia regulated by GATA2 mutations #IMGCGlasgow

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 08/04/2025

Our Director Owen Sansom describing decades long work that is now involving the Cancer Cluster to generate and characterise mouse models of colorectal cancer that more faithfully recapitulate human disease #IMGCGlasgow

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 08/04/2025

This morning session is Network loaded, starting with Sevda Boyanova from the @ukdri.ac.uk talking about the standardised phenotyping pipelines established for Alzheimer’s and frontotemporal dementia mouse models at the @mrcharwell.bsky.social Great attendance despite the early start! #IMGCGlasgow

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 07/04/2025

The Mary Lyon Award lecture given by Rachel Lynch of the University of North Carolina at Chapel Hill talking to us about the Systems Genetics Core Facility she heads and the challenges of maintenance and distribution of the Collaborative Cross strains #IMGCGlasgow @mmrrc.bsky.social

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 07/04/2025

Ageing Cluster member Nicholas Schaum presenting the cluster and the work he’s doing to advance our understanding of the ageing process and the possible intervention points for a healthier life using #mouse cohorts at different age points #IMGCGlasgow #AgeingResearch @mrcharwell.bsky.social

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 07/04/2025

Kicking off the main sessions today with a welcome from IMGS president Yan Herault and Network Director Owen Sansom #IMGCGlasgow

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 06/04/2025

Workshops in full swing with two of them led by us. Robert Pitceathly and Carlo Viscomi of the MitoCluster with Andrew Wood of the Degron Cluster running the Mouse models of mitochondrial DNA disease workshop. Sara Wells and Sonia Bains running the Home cage monitoring one. #IMGCGlasgow #ECRS

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 06/04/2025

Waiting for the delegates to come and start the science rolling. Trainee workshops and symposium today! #IMGCGlasgow

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 05/04/2025

Well, we’re ready to go! And well fed! See you all very soon at #IMGCGlasgow!

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 28/03/2025

Our Director, Owen Sansom, and @mrcharwell.bsky.social Director, Sara Wells, have been reaching out to US colleagues at the @jacksonlab.bsky.social to strengthen international #collaboration and #DataSharing in #PreClinical research using #MouseModels

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 11/03/2025

We are co-organising Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorder and infectious diseases, with the @cruk-si.bsky.social between 23rd and 26th September. Registration is open now: www.crukscotlandinstitute.ac.uk/organoids_ar...

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MRC National Mouse Genetics Network @mrcmousenetwork.bsky.social · 24/02/2025

Meeting to talk about our science for the next two years and beyond #ScienceAdvisory #networking

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