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Zwicker Group

@zwickergroup.bsky.social
1.6K followers 304 following 107 posts

Theoretical biophysics group at MPI-DS, Göttingen. We study the spatiotemporal organization of soft matter in cells, tissues, and synthetic systems; see www.zwickergroup.org

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Zwicker Group @zwickergroup.bsky.social · 07/10/2026
Arthur Hernandez joined our group! Arthur did his Ph.D. with Cristina Marchetti @ucsantabarbara.bsky.social and a first postdoc with Luca Giomi @unileiden.bsky.social. He will now work on various projects on growing active matter. Welcome aboard! 🎉
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Zwicker Group @zwickergroup.bsky.social · 05/10/2026
Our roadmap on biomolecular condensates made the cover of PRX Life: journals.aps.org/prxlife/ 🎉
Picture showing a schematic of two complex interacting condensates in the background of biomolecules. Image credits: APS/Ella Maru
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Stefan Köstler @stefankoestler2025.bsky.social · 28/09/2026
🚨New Preprint with @zwickergroup.bsky.social ! Phase-separated condensates 🫧 often encounter compositional gradients. We show that these gradients generically lead to surface-tension-driven propulsion even in the absence of surfactants. 📃 arxiv.org/abs/2609.24529
Droplet moving in a chemical gradient.
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Zwicker Group @zwickergroup.bsky.social · 21/08/2026
Our "Roadmap for Condensates in Cell Biology" (doi.org/10.1103/3b2k...) has finally been published PRX Life! 🎉 This forward-looking article summarizes amazing discussions of an interdisciplinary group of scientists at @kitp-ucsb.bsky.social last year.
doi.org
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Mesoscopic Physics of Life (MPoL) @m-pol.bsky.social · 06/08/2026
🚨 New preprint! From protein & RNA condensates to synthetic coacervates and DNA nanostars, vacuoles (dilute pockets inside droplets) show up everywhere. 🫧 We explain when and why they form. 🔬🧫 📄 arxiv.org/abs/2607.25743 w/ @boekhovenlab.bsky.social sky.social @kgoepfrich.bsky.social
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Zwicker Group @zwickergroup.bsky.social · 24/06/2026
Great choice for the name of the award and the first two recipients!
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Zwicker Group @zwickergroup.bsky.social · 23/06/2026
Ani Chattaraj 🇮🇳 has joined our group as a postdoc! Welcome aboard 🎉
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Zwicker Group @zwickergroup.bsky.social · 30/04/2026
In the end, patterns such as the one in the first post, comprise fundamental regions akin to phases, which coarsen over time in an intricate manner. Thanks to Chengjie, Yicheng, and Guido for the wonderful work!
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Zwicker Group @zwickergroup.bsky.social · 30/04/2026
We can also control the morphology of each pattern, i.e., whether they exhibit dots or stripes, and the associated length scales. Our constructive framework provides a way to compile an endless variety of patterns!
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Zwicker Group @zwickergroup.bsky.social · 30/04/2026
Even though these mixtures are driven out of equilibrium, we identify a class of systems that can be mapped to an equilibrium analog, which allows us to analyze them in detail. In particular, we can use Gibbs phase rule to identify how many fundamental patterns can coexist.
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Zwicker Group @zwickergroup.bsky.social · 30/04/2026
Our latest preprint at arxiv.org/abs/2604.26346 provides insights on chemically active mixtures that can produce mesmerizing patterns, such as this one:
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Ulrich Schwarz @ulrichschwarz.bsky.social · 13/03/2026
Friday afternoon and #DPG2026 is over. Like always, a great meeting, well-organized and highly interesting👍This time with France as a guest country and many high-profile speakers from Dresden. Looking forward to #DPG2027 at Regensburg😀
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Max Planck Institute for the Physics of Complex Systems @mpipks.bsky.social · 03/03/2026
The Division of Biological Physics @mpipks.bsky.social seeks a Research Group Leader in #biophysics, #softmatter physics, or related areas. (Further particulars in the ad.) Apply by the 3rd of April 2026 at pks.mpg.de/bprgl to join us in Dresden!
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Laboratory of Soft and Living Materials @SoftLiv_Cornell @softliv.bsky.social · 28/02/2026
Our second Cornell-era preprint is also out! Kaarthik's paper discusses the gap between cellular and in vitro condensates. In cells, condensates are low-contrast (small partition coefficients), enabling a wide range of responses. Congrats, Kaarthik and the team! www.biorxiv.org/content/10.6...
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Simone Reber @simonereber.bsky.social · 23/02/2026
Density. Crowding. Tomato. Tomato 🍅 @gabepopkin.bsky.social kin.bsky.social @quantamagazine.bsky.social Thx for covering the debate! We promise we're all friends 🥰 @liamholt.bsky.social & @gwgl.bsky.social Nothing would have been possible without @gucklab.bsky.social @vasilyzaburdaev.bsky.social
quantamagazine.org
The Biophysical World Inside a Jam-Packed Cell | Quanta Magazine
Innovations in imaging and genetic engineering are coming together to probe the biophysics of cytoplasm inside living animals.
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Karen Alim @karenalim.bsky.social · 04/02/2026
Less than two weeks left to apply for a Theory Post-doc on Learning in Biological and Soft Matter with us @TU_Munich. Uncover how flows transport and process information to solve complex tasks. #PhDposition #academicjobs www.bpm.ph.tum.de/join-us/
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EMBO @embo.org · 02/02/2026
The EMBO Young Investigator Network consists of young investigators, installation grantees and global investigators. 🧪 Find more information on the individual programmes here: www.embo.org/the-embo-communities/e… #LifeSciences #research #funding
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Magnus Kjærgaard @proteinmagnus.bsky.social · 02/02/2026
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction. Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates. doi.org/10.64898/202...
Graphical abstract of pre-print
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Brugues Lab @brugueslab.bsky.social · 28/01/2026
Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de
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Zwicker Group @zwickergroup.bsky.social · 28/01/2026
The final version of the review has now been published at Rep. Prog. Phys.: doi.org/10.1088/1361... We hope the review is helpful, and we'd like to thank everyone who helped us improve the text during the revision phase!
doi.org
Physics of droplet regulation in biological cells
Physics of droplet regulation in biological cells, Zwicker, David, Paulin, Oliver W, ter Burg, Cathelijne
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Max Planck Institute for the Physics of Complex Systems @mpipks.bsky.social · 28/01/2026
You have a background in math/physics/computer science/ML and are looking for an interdisciplinary postdoc fellowship in life sciences with free choice of host groups? Then join us at the CSBD as an ELBE postdoc! The application deadline is the 13 of March
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Lennart Hilbert @lennarthilbert.bsky.social · 15/01/2026
Our Mini Review went online last night in Current Opinion in Genetics & Development "Block copolymer concepts of how transcription organizes the stem cell genome" doi.org/10.1016/j.gd... Fig. 1: Stem cell–typical organization of the genome and transcription, and the block copolymer sorting concept.
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Zwicker Group @zwickergroup.bsky.social · 15/01/2026
Excited to talk to the Matter to Life community about droplets and life!
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Jerelle Joseph @jerelleaj.bsky.social · 14/01/2026
How does protein folding change inside biomolecular condensates? Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social
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Andrew Plested @andrewplested.bsky.social · 08/01/2026
"While the concept of condensates is successfully rewriting cell biology textbooks, there is some danger of overhype and backlash." This workshop summary is great - particularly the idea to shift from "Is it a condensate?" to "what problem does that solve?" but "successfully" stood out for me here
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Zwicker Group @zwickergroup.bsky.social · 08/01/2026
Curtesy of @jerelleaj.bsky.social who was our amazing master of the black board!
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Zwicker Group @zwickergroup.bsky.social · 08/01/2026
Our "Roadmap for Condensates in Cell Biology" is now available on arXiv: arxiv.org/abs/2601.03677 🎉 This article summarizes the interdisciplinary weekly discussions we had at our condensate workshop at KITP in the summer of 2025. Feedback is very welcome!
arxiv.org
Roadmap for Condensates in Cell Biology
Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting t...
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Zwicker Group @zwickergroup.bsky.social · 30/12/2025
All the best, Aljaz!
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Zwicker Group @zwickergroup.bsky.social · 17/12/2025
We're looking for a postdoc to strengthen our group! Please apply by January 15, 2026 if you're a fun and motivated person who likes theoretical modeling of biological processes by combining analytics and numerics. There is freedom in choosing projects! Details: www.ds.mpg.de/4110032/job_...
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Zwicker Group @zwickergroup.bsky.social · 15/12/2025
Our work helps us to understand the fundamental behaviors of chemically active droplets. We hope that it guides future understanding of biomolecular condensates and also experiments reconstituting these droplets in synthetic systems. Details are available in the pre-print: arxiv.org/abs/2512.02542
arxiv.org
Size control guidelines for chemically active droplets
Biological cells and synthetic analogues use liquid-liquid phase separation to dynamically compartmentalize their environment for various applications. In many cases, multiple droplets need to coexist...
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Zwicker Group @zwickergroup.bsky.social · 15/12/2025
More generally, we identified that reactions can either take place in the entire droplet volume or just in a region limited to the interface. These two different classes of droplets behave qualitatively differently.
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Zwicker Group @zwickergroup.bsky.social · 15/12/2025
Our simplest model describes a binary fluid, which exhibits phase separation and conversion of the two species into each other. Using linear non-equilibrium thermodynamics, we asked how different conversion rates affect droplet sizes, and this parameter dependence turned out to be complex.
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Zwicker Group @zwickergroup.bsky.social · 15/12/2025
Since more than a decade, our group has been exploring chemically active droplets, which are exciting since their size can be controlled. Yet, we still do not fully understand this control even in the simplest models. Until a new preprint (arxiv.org/abs/2512.02542) spearheaded by postdoc Guido...
arxiv.org
Size control guidelines for chemically active droplets
Biological cells and synthetic analogues use liquid-liquid phase separation to dynamically compartmentalize their environment for various applications. In many cases, multiple droplets need to coexist...
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Zwicker Group @zwickergroup.bsky.social · 02/12/2025
Congratulations, Anna! Welcome to this great program 🎉
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Zwicker Group @zwickergroup.bsky.social · 27/11/2025
Wow, congratulations!
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Ulrich Schwarz @ulrichschwarz.bsky.social · 24/11/2025
📢 Paper alert 📢 Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns: doi.org/10.1038/s415... Here comes a 🧵 ... (1/9)
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Zwicker Group @zwickergroup.bsky.social · 24/11/2025
In contrast, short-range interactions (e.g., non-local elasticity and Riccardo's system discussed above) show various patterns, which can be explained by a mapping to the Swift-Hohenberg model. These results demonstrates that various processes arresting droplet coarsening fall into two categories.
Four simulation snapshots showing various possible configurations in phase separating systems with short-range interactions.
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Zwicker Group @zwickergroup.bsky.social · 24/11/2025
Filipe's work (in collaboration with Yicheng and Oliver) puts these results in context by generally studying the influence of non-local interactions onto phase separation. We find that long-range interactions (e.g., electrostatics and also chemical reactions) generally suppress phase separation.
Simulation snapshot showing a patterned phase with many small droplets  in a hexagonal arrangement.
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Zwicker Group @zwickergroup.bsky.social · 24/11/2025
Active processes can further control the droplet dynamics. They can either accelerate coarsening, or they can suppress it completely. In the latter case, we also find interesting states where a macroscopic droplet coexists with a patterned phase comprising many smaller spots.
Simulation snapshot showing a single large droplet coexisting with a patterned phase comprising multiple smaller droplets.
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Zwicker Group @zwickergroup.bsky.social · 24/11/2025
Riccardo and Gerrit looked at condensates embedded in membranes, using polarity spots of yeast as an example. They showed that exchange with the bulk can strongly accelerate coarsening, allowing cells to form one spot quickly.
Top: Schematic of our model describing interacting solutes that phase separate in a 2D surface and exchanges with a 3D bulk. Bottom: Snapshots of numerical simulations with and without passive exchange.
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Zwicker Group @zwickergroup.bsky.social · 24/11/2025
Two more pre-prints from the group 🎉 Riccardo explored how cells could control surface condensates by regulating bulk exchange (arxiv.org/abs/2511.03619). Filipe studied the impact of non-local interactions onto phase separation (arxiv.org/abs/2511.05214). Some more details in the thread:
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Zwicker Group @zwickergroup.bsky.social · 21/11/2025
No, I don’t agree with such a blanket statement. Equilibrium concepts can also be useful in non-equilibrium situations. For instance, phase coexistence may hold at the interface, while active processes modulate the bulk phases. I propose a more nuanced view, depending on the concrete system.
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Zwicker Group @zwickergroup.bsky.social · 21/11/2025
I don’t know the details of this paper, but one generally needs to be cautious. Phase separation can be a useful conceptual framework, but since cells are complex, it can rarely be „proven“.
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Zwicker Group @zwickergroup.bsky.social · 21/11/2025
Our review on the physics of phase separation in cells has been published by Rep. Prog. Phys. 🎉 doi.org/10.1088/1361... We hope that the text and citations are helpful for anyone interested in physical descriptions of condensates in cells!
doi.org
Physics of droplet regulation in biological cells - IOPscience
Physics of droplet regulation in biological cells, Zwicker, David, Paulin, Oliver W, ter Burg, Cathelijne
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Zwicker Group @zwickergroup.bsky.social · 02/10/2025
Another pre-print from our group see's the light of day! 🎉 This time we how the coarsening of droplets is affected by advection and reactions: arxiv.org/abs/2510.00827 @stefankoestler2025.bsky.social describes our surprising findings in the thread below ⤵️
arxiv.org
Advection selects pattern in multi-stable emulsions of active droplets
Controlling the size of droplets, for example in biological cells, is challenging because large droplets typically outcompete smaller droplets due to surface tension. This coarsening is generally acce...
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Zwicker Group @zwickergroup.bsky.social · 30/09/2025
Our latest work from a stimulating collaboration with @jerelleaj.bsky.social and @nathanieldhess.bsky.social is out now!
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Zwicker Group @zwickergroup.bsky.social · 29/09/2025
A great example of a totally unplanned discovery in our group, spearheaded by a Bachelor and a PhD student! Curiosity wins 🥳
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Noah Ziethen @nziethen.bsky.social · 29/09/2025
New preprint 🎉 What began as Frieder Johannsen’s bachelor thesis in the @zwickergroup.bsky.social (which I had the pleasure to supervise) evolved into our latest paper: “Chemically Active Liquid Bridges Generate Repulsive Forces” — unlike passive ones, which attract. 📄 arxiv.org/abs/2509.18777
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Zwicker Group @zwickergroup.bsky.social · 23/09/2025
It was fun to do a little interview and think about the relevance of our work for a more experimental and engineering inclined community.
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Denis Wirtz @deniswirtz.bsky.social · 22/09/2025
We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics. We applied this workflow to map precancerous lesions of the fallopian tubes. More here: www.biorxiv.org/content/10.1...
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