Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.

Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic health via sperm microRNAs that reprogram gene expression in early embryos, revealing how exercise benefits c...

Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individu...

An analysis of prescription medications shows that several non-antibiotic drugs, such as the heart medication digoxin, can reduce the immune response to pathogens and increase the risk of gastrointest...

Education, body mass index (BMI), and hypertension play a role in the spread of tau tangles, a hallmark of Alzheimer’s disease, according to longitudinal PET imaging data presented at the 2025 Society...

npj Biofilms and Microbiomes - Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese...

The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.

A new study reveals that caffeine increases the complexity of brain activity during sleep, especially in younger adults, potentially disrupting the brain’s ability to recover overnight.

Social interaction has been shown to prolong lifespan and healthspan. For older adults living alone, social interaction largely comes from formal social participation, and thus depends on the sociabil...

The latest science suggests our fiber-poor diets trigger inflammation and contribute to a range of related diseases.

AbstractBackground and Aims. While the rationale for coronavirus disease 2019 (COVID-19) vaccination is to reduce complications and overall mortality, some

Heo, Xu et al. used comprehensive plasma proteomics to identify 416 plasma proteins (294 new) associated with Alzheimer’s disease and applied machine learning to select 7 proteins that were highly pre...

A Time of Optimism for Primary Prevention of the Major Age-Related Diseases

Bacterial colonies, as dynamic ecosystems, display intricate behaviors and organizational structures that profoundly influence their survival and functionality. These communities engage in physiologi....

In biofilms, genetically identical cells exhibit diverse gene expression, resulting in subpopulations of functionally distinct and coexisting cell types, such as motile cells, extracellular matrix pr...

Eric Topol, MD, discusses the revolutionary impact of artificial intelligence (AI) in medicine and healthcare and how AI can help strengthen the patient-doctor relationship and reduce medical errors ....