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Yisui Xia

@yyxia.bsky.social

Young PI in Medical School of Shenzhen University on studying DNA replication in metazoa. Postdoc was in Karim Labib Lab.

Posts Replies Media

Reposted by Yisui Xia

Deegan Lab @deeganlab.bsky.social · 14/04/2026

Delighted to be awarded The Colworth Medal! Thanks especially to lab members, mentors and colleagues past and present.

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Reposted by Yisui Xia

The Francis Crick Institute @crick.ac.uk · 23/03/2026

“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...

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Reposted by Yisui Xia

The EMBO Journal @embojournal.org · 05/03/2026

Asgard #archaea: have we found our microbial ancestors? New review (also for newcomers to the field!) by Christa Schleper and Thiago Rodrigues-Oliveira link.springer.com/article/10.1...

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Reposted by Yisui Xia

Zha Lab @zhalab.bsky.social · 19/12/2025

Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro...

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Reposted by Yisui Xia

The EMBO Journal @embojournal.org · 28/11/2025

MCM loading onto replication origins: when does it need ORC6 and when not? AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa www.embopress.org/doi/full/10....

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Yisui Xia @yyxia.bsky.social · 22/11/2025

Lots of fun for Masto's visiting😁😁😁

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Reposted by Yisui Xia

Ernst Schmid @ernstschmid.bsky.social · 12/11/2025

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

biorxiv.org

Proteome-wide in silico screening for human protein-protein interactions

Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

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Reposted by Yisui Xia

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 22/10/2025

Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing Read more: www2.mrc-lmb.cam.ac.uk/a-new-method... #LMBResearch

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Yisui Xia @yyxia.bsky.social · 19/09/2025

Now we are looking for in vitro evidence on MCM UFMylation💪

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Reposted by Yisui Xia

Rockefeller University Press @rupress.org · 16/07/2025

In @jcb.org, the @hanasedlackova.bsky.social lab presents a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

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Reposted by Yisui Xia

Journal of Cell Biology @jcb.org · 16/07/2025

Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

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Yisui Xia @yyxia.bsky.social · 13/07/2025

Last day in Dundee. Sweet 9 years. Moving on, a step forward from postdoc to young PI.

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Reposted by Yisui Xia

Aga Gambus @agagambus.bsky.social · 10/07/2025

It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

academic.oup.com

CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS

Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic

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