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Dr. Arpiar Saunders

@your-arpy.bsky.social
81 followers 55 following 11 posts

Neuroscientist and molecular engineer at the Vollum Institute (OHSU). Our lab maps the molecular, cellular and synaptic organization of the brain through viral genomic technology. Opinions my own.

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Reposted by Dr. Arpiar Saunders
Vollum Institute @volluminstitute.bsky.social · 26/06/2025
For the first time, scientists using #cryoelectron microscopy have discovered the structure and shape of key receptors connecting #neurons in the brain’s cerebellum, which plays a critical role in functions such as coordinating movement, balance and cognition. #OHSUResearch bit.ly/4b9gOw9
Left to right: Laurence Trussell Ph.D., Natalie Sheldon, Chengli Fang Ph.D., Jumi Park Ph.D. and Eric Gouaux Ph.D.; Cathy Spangler Ph.D. is not pictured.
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Dr. Arpiar Saunders @your-arpy.bsky.social · 15/06/2025
Portland, OR showing OUT for #nokings. To hamper a guess - 30,000, maybe more? - saying hell no to Trump et al in a wonderful and humorous way. So tough to distill a protest sign to dissent against such a broad collection of despicable policies…I went with #TrumpIsGarbage
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Reposted by Dr. Arpiar Saunders
Kevin Wright @kevinmawright.bsky.social · 15/06/2025
No exaggeration, the protest march had probably close to two miles long of wall-to-wall people walking at once
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Reposted by Dr. Arpiar Saunders
Jeremy Berg @jeremymberg.bsky.social · 09/06/2025
New York Times story about #BethedaDeclaration is up. (Gift Link) www.nytimes.com/2025/06/09/h...
nytimes.com
N.I.H. Workers Denounce Trump’s ‘Harmful’ Health Policies
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Jeremy Berg @jeremymberg.bsky.social · 06/06/2025
Outstanding op-ed from Carole LaBonne Universities and the government: Which needs the other more? College-based research labs are the workhorses of national progress and prosperity. wapo.st/3ZR1vFm 1/n
wapo.st
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Kevin Wright @kevinmawright.bsky.social · 05/06/2025
www.nature.com/articles/s42...
nature.com
Distinct functional domains of Dystroglycan regulate inhibitory synapse formation and maintenance in cerebellar Purkinje cells
Communications Biology - Genetic manipulation of functional domains on Dystroglycan reveals distinct developmental roles in inhibitory synapse formation and maintenance in cerebellar cortex.
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Calli McMurray @callimcflurry.bsky.social · 04/06/2025
FlyBase, a crucial resource for drosophila research, has lost its funding because its grant is awarded to Harvard. The team is scrambling to find other sources of funds, including donations from labs. Read more: www.thetransmitter.org/community/fl... @flybase.bsky.social
thetransmitter.org
FlyBase funding squashed amid Harvard grant terminations
The team behind the Drosophila genetics database is now requesting donations from labs to keep the resource afloat.
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Reposted by Dr. Arpiar Saunders
Jerzy Szablowski @jerzyszablowski.bsky.social · 03/06/2025
How can you know if gene delivery in a primate worked Typically through expensive scans or histology. With @vincentcostaphd.bsky.social and co-authors we made synthetic markers that monitor gene delivery and Cre-dependent expression with a blood test: www.biorxiv.org/content/10.1...
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Eric Topol @erictopol.bsky.social · 30/05/2025
"Our calculations suggest that the proposed budgetary cuts to the NIH will create a social cost that is 16 times greater than the savings that the administration is attempting to achieve." jamanetwork.com/journals/jam...
jamanetwork.com
Cutting the NIH—The $8 Trillion Health Care Catastrophe
This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...
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Avery Davis Bell @averydb.bsky.social · 28/05/2025
I am deeply furious. Lost an expected baby last fall (harrowing in GA because of bad abortion laws) and now any future pregnancy I may be able to have is higher risk because I can’t get this safe effective vaccine. Insult to injury, AGAIN. These rules are terrible for families.
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Dr. Arpiar Saunders @your-arpy.bsky.social · 07/05/2025
@kennypavan.com's AnnSQL software for facile, lightning-fast analysis of large-scale scRNA-seq datasets is out now in @bioinfoadv.bsky.social. >19k downloads thus far and we'd love to grow the developer base. Easily analyze millions of RNA profiles from your laptop. No HPC necessary!
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Kevin Wright @kevinmawright.bsky.social · 16/04/2025
www.oregonlive.com/education/20...
oregonlive.com
Portland physics student flees Trump crackdown, months from earning his doctorate
“People need to know that this is happening, and this is wrong,” the man’s physics supervisor at Portland State University said.
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Reposted by Dr. Arpiar Saunders
Ardem Patapoutian @ardemp.bskyverified.social · 09/04/2025
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...
cnn.com
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
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Sarah Stern @sarahstern.bsky.social · 09/04/2025
If you’re a scientist whose funding has recently been cut or impacted, I would love to interview you and amplify your work! Hoping to release our first two podcast episodes next week. Please share widely!
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Dr. Arpiar Saunders @your-arpy.bsky.social · 05/04/2025
Ended up in tiny Tillamook, OR this weekend with the fam and was heartened to join hundreds of #handsoff protesters. I’d say 85% positive car responses in a county that went 50/50 in November.
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Dr. Arpiar Saunders @your-arpy.bsky.social · 01/04/2025
In recognition of an extraordinary track record of intra and extramural dopamine fluffing at the @volluminstitute.bsky.social
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Dr. Arpiar Saunders @your-arpy.bsky.social · 26/03/2025
Please check out AnnSQL v1 if you’re working with large single-cell/nucleus RNA-seq datasets! Blazing fast! New features!
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Jeremy Berg @jeremymberg.bsky.social · 22/02/2025
We need to make sure that everyone understands how important science is for EVERYONE not just for scientists...
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Vaughn Cooper @vscooper.micropopbio.org · 22/02/2025
Deep and thoughtful reporting on the crises of the NIH funding and review blocks. Share locally, share widely. And make sure your reps know! www.washingtonpost.com/science/2025...
washingtonpost.com
Scientists warn of long-term damage as Trump’s orders slow research
By blocking announcements in the Federal Register, the administration is keeping experts from meeting to evaluate funding proposals.
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NPR @npr.org · 22/02/2025
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
npr.org
NIH funding freeze stalls applications on $1.5 billion in medical research funds
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 17/02/2025
If you are a journalist--this should be your biggest story. Musk is denying hope to patients who have exhausted all other options 🧪
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Dr. Ahna Skop @ahnaskop.bsky.social · 15/02/2025
nytimes.com
How Trump’s Medical Research Cuts Would Hit Colleges and Hospitals in Every State
Changes to a key funding formula will reduce research grants at hospitals and universities by billions — and may discourage future research.
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Rick Huganir @rhuganir.bsky.social · 15/02/2025
I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all. time.com/7216299/nih-...
time.com
Experts Call NIH Budget Cuts an 'Apocalypse' for Science
The reductions target indirect costs that cover administrative and equipment costs.
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Stephen Floor @snf.bsky.social · 09/02/2025
not paying indirect costs for research is like only paying the players in the Super Bowl. can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities
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Sarah Tishkoff, PhD @sarahtishkoff.bsky.social · 08/02/2025
Apologies for this long post I put together to explain to non-scientists the impact of NIH cuts: Last night, an “atomic bomb” was dropped on the biomedical science community. We were informed that effective immediately, indirect costs on NIH grants (both current and future) would be fixed at 15%.
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Dr. Arpiar Saunders @your-arpy.bsky.social · 09/02/2025
It’s important for us scientists to articulate that the NIH cuts are surgically cruel: designed not to save money, but to maximally implode the capacity and infrastructure for research; research that saves and improves lives around the world. Why? Just cruelty.
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Carl T. Bergstrom @carlbergstrom.com · 08/02/2025
8. It is difficult to overstate what a catastrophe this will be for the US research and education systems, particular in biomedical fields. It is deliberate and wanton devastation entirely out of scale with any concern about DEI activities on campuses. The goal is destroy US universities.
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John Tuthill @tuthill.bsky.social · 03/02/2025
I was supposed to give a talk in the NIH Neuroscience Seminar Series today, but it was cancelled because of Trump's executive orders. research.ninds.nih.gov/seminars-eve... Amongst the deluge, it seems that most Americans remain unaware that Trump is paralyzing the biomedical research community.
research.ninds.nih.gov
Neuroscience Seminar Series | NINDS Division of Intramural Research
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Reposted by Dr. Arpiar Saunders
Kenny Pavan @kennypavan.com · 02/01/2025
Let's talk about inte𝗥operability. The Python based AnnSQL package transforms AnnData objects into easily shareable persistent databases. Using the DuckDB R package, you can easily open these databases to run fast, easy queries 🧬🖥️🧪 #SingleCell #R #inteRoperability www.biorxiv.org/content/10.1...
An example R script showing how an AnnSQL database file can be accessed using R by using the DuckDB R API.
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