Stem-cell-derived β-like-cells (SCβ-cells) provide a promising platform for diabetes modelling and cell replacement therapy, but their incomplete functional maturation remains a challenge. Here, we co...

The organizers of the American Diabetes Association meeting had a group of researchers removed from the event for sharing an editorial about negative impacts of policy changes to research funding.

Aims/hypothesis In people with type 2 diabetes and obesity, Roux-en-Y gastric bypass (RYGB) can induce remission of diabetes. While RYGB has been reported to improve beta cell function in individuals ...

Aims/hypothesis The role of intra-pancreatic lipid and collagen in type 2 diabetes pathogenesis remains unclear. We sought to examine this in pancreases from organ donors with and without diabetes. Me...

Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...

Aims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...

Wang, Cardoso, and Cai et al. design synthetic insulin receptor agonists that impose distinct receptor conformations, leading to modulated signaling. These agonists outperform insulin in metabolic con...

Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

Agonist-dependent interactions between a GPCR and its accessory proteins affect signaling by peptide hormones.

D-lactate from the gut microbiota influences blood glucose and fatty liver disease. Trapping D-lactate in the gut improves blood glucose and lowers liver inflammation and fibrosis during obesity.

In type 1 diabetes (T1D), insulin (INS) deficiency results from immune-mediated destruction of β-cells. The majority of functional β-cell mass is typically

Using in vitro models of lipotoxicity and islets from the db/db mouse model of type 2 diabetes (T2D), we show that endoplasmic reticulum (ER) stress i…

Amylin is a peptide hormone involved in satiation. Amylin mimetics have potential as therapies for obesity and diabetes mellitus, but clinical development has proven challenging. This Review discusses...

Advancing equity, diversity, and inclusion (EDI) in scientific fields is an outstanding challenge. While there is growing awareness of barriers and challenges to EDI across science, technology, engine...

Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...

Targeting beta cell proliferation is an appealing approach to restore glucose control in type 1 diabetes. However, the underlying mechanisms of beta cell proliferation remain incompletely understood, ...

Tenure track position in physiology, pharmacology and/or toxicology at the Western College of Veterinary Medicine

Increased activity of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome–IL-1β pathway is observed in obesity and contributes to the development of type 2 diabetes and its compli...