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Wen Ding

@wyd20.bsky.social
382 followers 711 following 27 posts

Paediatric nephrologist in Bristol, progressing kidney gene 🧬therapy, mum of boys, loves ballet/ gymnastics/ dance

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Wen Ding @wyd20.bsky.social · 03/10/2025
Kidney disease affects 1 in 10 of the UK population and has largely been overlooked in the UK 10 Year Health Plan. Please sign this petition by Thursday 9th October to emphasise the importance of a national strategy for kidney disease. www.ukkidney.org/prime-minist...
ukkidney.org
Add Your Name: Call on the Prime Minister to Tackle Kidney Disease
Kidney disease affects more than 7 million people in the UK, yet was largely overlooked in the Government’s new 10-year health plan for the NHS. Without action, it will place an unsustainable burden o...
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Wen Ding @wyd20.bsky.social · 25/09/2025
Great talk about the Hidden initiative from Kate Bramham and detecting CKD in the community in London. Absolutely inspirational @kidneyresearchuk.org
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Wen Ding @wyd20.bsky.social · 25/09/2025
Having a fantastic time listening to all the progress in kidney research in the UK @kidneyresearchuk.org driving discoveries. Fantastic talk @willkidney.bsky.social about how large well designed trials have changed our practice in nephrology
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Sampson Lab for Kidney Genomics @thesampsonlab.bsky.social · 24/07/2025
Your kidneys are working hard for you every day, every hour. Return the favor with these small habits that lead to lifelong health. 💬 Which of these do you already do? Which one could you start this week? #KidneyFacts #HealthyKidneys #NephrologyTips #BIGKiDsStudy #KidneyHealthAwareness #sampsonlab
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 29/05/2025
Sibeprenlimab inches closer to approval www.hcplive.com/view/fda-acc... feat @brendonneuen.bsky.social Phase 3 RCT next week at #ERA25 (& some journal?)
hcplive.com
FDA Accepts, Grants Priority Review to Sibeprenlimab BLA for IgA Nephropathy
With the priority review acceptance of the Biologics License Application, the FDA has assigned a PDUFA target action date of November 28, 2025.
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Michelle Rheault, MD @rheaultm.bsky.social · 20/05/2025
Sparsentan for FSGS?? It's alive.... ir.travere.com/press-releas...
ir.travere.com
Travere Therapeutics Announces FDA Acceptance of sNDA for FILSPARI® (sparsentan) in FSGS
PDUFA target action date of January 13, 2026 If approved, FILSPARI would be the first and only FDA-approved treatment for FSGS, a rare kidney condition and a leading cause of kidney failure Travere Th...
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WHO @who.int · 24/04/2025
It’s #WorldImmunizationWeek Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute. A reminder of what is #HumanlyPossible. Science saves lives. #VaccinesWork bit.ly/wiw2025
Every 10 seconds vaccination saves a life.
Immunization for all is Humanly Possible
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Chris Fell @cfell.bsky.social · 09/04/2025
So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵 www.nature.com/articles/s41...
nature.com
Reprogramming site-specific retrotransposon activity to new DNA sites - Nature
A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...
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Wen Ding @wyd20.bsky.social · 02/04/2025
Interesting!
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Eric Topol @erictopol.bsky.social · 23/02/2025
Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...
Design of study using sequencing of B and T cell receptor and A.I. models to unravel information about infections and autoimmune conditions
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Wen Ding @wyd20.bsky.social · 10/02/2025
What an exciting time to be a nephrologist. Yet another really promising therapy for IgA. Decreases proteinuria significantly, likely will be spoilt for choice soon but how will be choose the right meds for the right patient?
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Wen Ding @wyd20.bsky.social · 10/02/2025
Not apologising for posting this paper twice as really excited about ProtGPS. Logical next step in protein modelling after the success of alphafold2. Not only will help predict pathogenicity of genetic variants but can incorporate elements for subcellular compartmentalisation in gene therapy design
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Di Jiang @dijiang319.bsky.social · 08/02/2025
🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social
science.org
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
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Neil Shubin @neilshubin.bsky.social · 08/02/2025
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
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Wen Ding @wyd20.bsky.social · 29/01/2025
No idea how the academic world would cope without pubmed
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Wen Ding @wyd20.bsky.social · 21/01/2025
Fascinating read: history of ISKDC. Our current management of nephrotic syndrome not very different from this first nephrotic syndrome RCT. (Other than AZA which was shown not to be useful in iNS) media.springernature.com/full/springe...
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Dr Anastasia S Mihailidou PhD FAHA FCSANZ FESC @anastasiasmihaili.bsky.social · 08/01/2025
Why we need to start monitoring #BP before adulthood for #cardiovascular #prevention #CvPrev Adolescent #BloodPressure & Early Age #Stroke in @nejm.org Evidence evidence.nejm.org/doi/full/10....
evidence.nejm.org
Adolescent Blood Pressure and Early Age Stroke
Underdiagnosis of relevant risk factors has contributed to the increasing stroke incidence in young adults. Blood pressure cut-off values for adolescents are neither sex specific nor based on cardi...
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Krutika Kuppalli, MD FIDSA @krutikakuppalli.bsky.social · 01/01/2025
This 13-year-old received 3 antivirals and plasma exchange for #H5N1. In over a decade as an ID doctor, I've never used such measures for #Influenza— not even during H1N1. #H5N1 is alarming; we must boost surveillance, testing, prevention, and education to control it. www.nejm.org/doi/full/10....
nejm.org
Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection | NEJM
Influenza A(H5N1) viruses are an emerging zoonotic threat and have spread widely throughout birds in North America. Recently, influenza A(H5N1) infection led to serious illness in a teenager in Canada.
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Wen Ding @wyd20.bsky.social · 28/12/2024
Chronic Kidney Disease is rising in prevalence--I have signed this petition for the World Health Organisation to recognise kidney health as a priority, do consider signing to prioritise preventing premature death from kidney disease #nephsky #medsky #pedsky
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Wen Ding @wyd20.bsky.social · 20/12/2024
😱 Have never dared to use any of these but surely you would check through carefully if you did! Worrying that these passed peer review, editorial boards etc 🤔
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Jennifer Chen, MD FAAP @drjenchen4kids.medsky.social · 16/12/2024
#PedSky appreciation post: Dr. Weyand’s posts are why I now check ferritin/CRP for every anemia screen (w CBC + retic)! I’ve caught so many w single digit ferritin levels even if Hgb is “normal” 😱 It’s also an issue in “picky eaters” even if they’re not menstruating
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Matt Sampson @kidneyomicsamps.bsky.social · 09/12/2024
A great keynote by Moin Saleem from Bristol UK, followed by a terrific discussion @rfsgsinitiative.bsky.social @genetickidneydoc.bsky.social @opeyemiolabisi.bsky.social @gbadegesinlab.bsky.social
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Itai Yanai @itaiyanai.bsky.social · 08/12/2024
Some papers are very difficult to read but that doesn’t necessarily mean they're deeper than other papers. Authors must work very hard to make their story easy to read and understand by others. Or as Stephen King says: "the shorter the book, the less bullshit".
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Kidney Care UK @kidneycareuk.bsky.social · 29/11/2024
Hello and thank you to all who have followed us so far! Look out for some of our posts coming to #Bluesky soon 😍 In the meantime, if you are living with #ChronicKidneyDisease and need support from us, please visit our website: kidneycareuk.org/get-support/ #KidneyCareUK #CKD #CKDSupport #Dialysis
kidneycareuk.org
Help and support
Find out about our free patient services for kidney patients and their families: financial grants, advocacy and expert advice and specialist renal counselling sessions.
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Johanna Joyce @johannajoyce.bsky.social · 25/11/2024
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/
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Tony Breu @tonybreu.bsky.social · 28/11/2024
1/9 🤔 Why doesn't an elevated BUN lead to extreme thirst? If increased serum osmolarity compels us to seek water, uremia should be a significant driver of this craving. And yet, it isn't. Let's examine why.
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Wen Ding @wyd20.bsky.social · 27/11/2024
❤️Great visual abstract of the original ISKDC study for NS from 50 years ago! high dose steroids magically melts away childhood NS but can we do better? In an ideal world: ✔️equally efficacious induction therapy ✔️minimal side effects ✔️cost effective-equal access in LMICs where NS incidence higher
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Wen Ding @wyd20.bsky.social · 25/11/2024
😱 although hopefully a risk factor only in select age groups.
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Jan Klocke @janklocke.bsky.social · 16/11/2024
To celebrate the growing #medsky / #nephsky community, I will post one silly med/kidney cartoon every day for one month! d6: you guessed it - postrenal AKI
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Jan Klocke @janklocke.bsky.social · 15/11/2024
To celebrate the growing #medsky / #nephsky community, I will post one silly med/kidney cartoon every day for one month! d5: intrarenal AKI
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Wen Ding @wyd20.bsky.social · 23/11/2024
Loving these kidney cartoons 🥰
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Dr Louise Oni @louiseoni.bsky.social · 21/11/2024
theipna.org/ipna-2024-pr... Please support the phenomenal @RukshanaShroff who is running as President Elect for @IPNA_PedNeph - the future of paeds neph would be in safe hands if successful.
theipna.org
Login - IPNA Online - International Pediatric Nephrology Association
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Wen Ding @wyd20.bsky.social · 22/11/2024
Looks like a great resource, will be directing vaccine hesitant parents to this, as often tricky to cover this in any great detail in a paediatric nephrology clinic.
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Wen Ding @wyd20.bsky.social · 18/11/2024
& Paediatrics starter pack here
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Ryan Town @kidneywiki.bsky.social · 10/11/2024
Starter pack specific for #PedNeph professionals. Hard to keep to with everyone joining so please let me know if you want to be added or see anyone missing! go.bsky.app/DEJdD5
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Wen Ding @wyd20.bsky.social · 18/11/2024
Bristol Royal Hospital for Children Journal Club today: NefIgArd (Lancet 2023). Really promising data showing oral targeted-release Budesonide for 9 months results in significant eGFR difference (5.05ml/min/m2, p<0.0001) and reduction in proteinuria at 2 years when compared against placebo. 1/
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