A new method enables engineered immune progenitor cells to replace microglia in mice and reveals how a genetic mutation can lead to inflammation in the brain.

Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …

Recent federal cuts to the NIH and the projected cuts to Medicaid will devastate health care and scientific advancements for all Americans. We will likely lose a generation of young scientists given t...

NIH-funded breakthrough could enable targeted therapies for many neurological disorders.

Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

The fact that some brain and spinal cord tumors are incurable is unacceptable. The fact that so many standard treatments have so many side effects is unacceptable. The fact that when tumors recur ther...

Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania announced the first ever direct approach to the depletion and replacemen...

Microglia and border-associated macrophages (BAMs) are critical for brain health, and their dysfunction is associated to disease. Replacing brain macr…

Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated ...

or technically, Positron Emission Tomography with [ 18 F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy [See original abstract on Pubmed]

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."

Gavin Nielsen, who was 2 years old when he was diagnosed with a rare brain cancer, met Dr. Nicholas Vitanza who is part of a growing group of researchers exploring CAR-T therapy. The treatment program...

In an early-stage clinical trial, the therapy nearly doubled the expected survival time of young patients. Still, experts caution that more research is needed.