Hirooka et al. show that Draper-mediated phagocytosis induces Upd3 in macrophages, amplifying tumor-derived Upds and activating JAK/STAT signaling, which promotes RasV12/scrib tumor growth in Drosophi...

Author summary Mutations in the invertebrate insulin/IGF signaling system robustly extend lifespan. Yet these interventions often cause insulin resistance, reduce growth, and impair fertility. In cont...

Dietary restriction (DR) slows aging in many animals, while in some cases, the sensory signals from diet alone are sufficient to retard or accelera...

Editors’ selections from the current scientific literature

Inflammatory cytokines hijack a brain circuit to cause apathy in cancer

Experiments in fruit flies reveal a mechanism that immune cells can use to control the availability of nutrients when fighting infections.

Adenosine produced by transmethylation may act as a sensor of the balance between cell activity and nutrient supply.

Science, both teaching and doing, is under attack. The recent US presidential election of a person and platform with anti-science bias exemplifies this. The study of climate processes and patterns and...