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Rob van Montfort

@robvanmontfort.bsky.social
156 followers 164 following 21 posts

Structural biologist at ICR London focused on cancer drug discovery. Views my own.

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Rob van Montfort @robvanmontfort.bsky.social · 24/08/2026
If you haven't seen our recent paper on the Fragment-Based Discovery of RNA competitive inhibitors of the DEAH-Box RNA helicase DHX8 yet, check out this excellent summary by Daniel Erlanson on the Practical Fragments Blog. practicalfragments.blogspot.com/2026/08/frag...
practicalfragments.blogspot.com
Fragments vs DHX8: towards a chemical probe
RNA helicases present an intriguing but challenging opportunity for drug discovery. Their importance for cell growth makes them attractive c...
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Rob van Montfort @robvanmontfort.bsky.social · 04/08/2026
Pleased to see our paper "Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8" published in J. Med. Chem. today. A great small-molecule drug discovery collaboration with Merck KGaA, Darmstadt, Germany pubs.acs.org/jmcmar/artic...
pubs.acs.org
Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8
Abstract. Human DHX8 is a spliceosomal DEAH-box RNA helicase involved in releasing mRNA from the spliceosome and crucial in ensuring splicing fidelity. DHX
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Rob van Montfort @robvanmontfort.bsky.social · 06/02/2026
Excited to share this preprint about the identification of TBK1 molecular glue degraders in a collaboration between NEOsphere Biotechnologies, @pmeier.bsky.social, and the Centre for Protein degradation @icr.ac.uk www.biorxiv.org/content/10.6...
biorxiv.org
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Rob van Montfort @robvanmontfort.bsky.social · 22/11/2025
It was a privilege to join the amazing Climb of Life to fundraise for the basic, translational, and clinical cancer research we do @ICR_London. www.linkedin.com/posts/the-in...
linkedin.com
#icrlondon #cancerresearch #climboflife | The Institute of Cancer Research
👣🥾⛰ 116 walkers braved a cold and windy Lake District last Friday to take part in the Climb of Life, raising £103, 215 for our research. We’re blown away by the generosity of everyone who participat...
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Rob van Montfort @robvanmontfort.bsky.social · 21/10/2025
In a couple of weeks Sonja and I are back in the beautiful Lake District for The Climb of Life, as we raise vital funds for the cancer research of the Institute of Cancer Research (@icr.ac.uk).If you would lke to supoort us, you can do so via this link. www.justgiving.com/page/sonja-r...
justgiving.com
The Climb of Life 2025
Help Sonja - Rob van Montfort raise money to support The Institute of Cancer Research (ICR)
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Rob van Montfort @robvanmontfort.bsky.social · 17/10/2025
Applications for PhD studentships @icr.ac.uk are now open. Are you interested in a PhD in structural biology applied to proteins involved in cancer? Check out the PhD-project available in my group. You can apply via the ICR website. Closing date is 16 November 2016. www.icr.ac.uk/study-and-ca...
icr.ac.uk
Elucidation of the molecular basis for the chaperoning of DEAH-box RNA helicases by the oncoprotein and cochaperone NudCD1
Elucidation of the molecular basis for the chaperoning of DEAH-box RNA helicases by the oncoprotein and cochaperone NudCD1
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Rob van Montfort @robvanmontfort.bsky.social · 30/06/2025
Thank you for a great day with us @icr.ac.uk and wonderful drug discovery talk @hartungingo.bsky.social!
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Agnieszka Konopacka @agako7.bsky.social · 13/05/2025
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Rob van Montfort @robvanmontfort.bsky.social · 02/05/2025
A nice blog about the acoustic dispensing robotics used in cancer drug discovery @icr.ac.uk. A big thank you to Mark Stubbs and Caroline Ewens for explaining it all! www.icr.ac.uk/research-and...
icr.ac.uk
How advances in technology are speeding up the discovery of new cancer drugs
How advances in technology are speeding up the discovery of new cancer drugs
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The Institute of Cancer Research @icr.ac.uk · 11/04/2025
NEWS: NICE has recommended capivasertib for advanced #BreastCancer. The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer. Read more about the history of the drug⬇️ www.icr.ac.uk/about-us/icr...
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Rob van Montfort @robvanmontfort.bsky.social · 29/03/2025
Fondly remember Jan for his enthusiasm, rigorous science, and the kind person that he was.
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Rob van Montfort @robvanmontfort.bsky.social · 20/03/2025
The Centre for Cancer Drug Discovery @icr.ac.uk looking fantastic in today's evening sun
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Peter Kenny @pwk2024.bsky.social · 20/03/2025
Sharp et al (2024) Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function. Nat Commun 15 10037 #TPD #FBDD #FBLD #MedChem #DrugDesign #DrugDiscovery #OpenAccess #chemsky 🧪 doi.org/10.1038/s414...
doi.org
Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function - Nature Communications
A structure-guided fragment screen identified a compound, which interacts with a ligand-binding site of unknown function in eukaryotic initiation factor 4E (eIF4E). X-ray crystallography was used...
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The Institute of Cancer Research @icr.ac.uk · 08/03/2025
Today is #InternationalWomensDay 👏 We are incredibly proud to celebrate the women of the ICR who are dedicated, driven, and determined to make a difference. You inspire us every day 👩‍🔬👩‍💻👩‍💼 #IWD2025 #AccelerateAction
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Titia Sixma @titiasixma.bsky.social · 20/02/2025
Today Jan Drenth would have been 100 years, but sadly he passed away last week. He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD.
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The Institute of Cancer Research @icr.ac.uk · 21/02/2025
It's #InternationalMotherLanguageDay 🌍 We're proud of our diverse community who are dedicated to defeating cancer. Our staff and students from across the globe come from a variety of backgrounds and cultures, and speak different languages, but are united by one mission ♥️
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Rob van Montfort @robvanmontfort.bsky.social · 21/02/2025
We are recruiting a Higher Scientific Officer experienced in recombinant protein production and assay development to join an exciting collaboration to develop novel small molecule-controlled molecular switches to modulate CAR-T cell activity. jobs.icr.ac.uk/vacancies/11...
jobs.icr.ac.uk
Higher Scientific Officer - Protein production, purification and assay specialist in Sutton | The Institute of Cancer Research
View details and apply for this Higher Scientific Officer - Protein production, purification and assay specialist vacancy in Sutton. Salary : Commencement on the salary range is subject ...
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Rob van Montfort @robvanmontfort.bsky.social · 21/02/2025
Are you interested to work in cancer drug discovery? Come and join us, we are recruiting a protein crystallographer to strengthen our structure-based drug discovery efforts. jobs.icr.ac.uk/vacancies/11...
jobs.icr.ac.uk
Postdoctoral Training Fellow – X-Ray Crystallography in Sutton | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow – X-Ray Crystallography vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Future progression is base...
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The Institute of Cancer Research @icr.ac.uk · 15/02/2025
📰 Prof Paul Workman, our former CEO, along with his team in our Centre for Cancer Drug Discovery, have made a breakthrough that could lead to new drugs for #chordoma — a rare #BoneCancer that led to the death of his mother. Read more in @theguardian.com ⤵️ www.theguardian.com/science/2025...
theguardian.com
British professor makes ‘thrilling’ breakthrough for cancer that killed his mother
Paul Workman has researched untreatable chordoma for years. Now new technology points towards to a potential drug to beat it
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The Institute of Cancer Research @icr.ac.uk · 11/02/2025
On International Day of Women and Girls in Science, we're celebrating our awe-inspiring women helping to defeat cancer 👩‍🔬👏 Hear from Professor Ros Eeles, Professor Helen McNair (The Royal Marsden NHS) and ICR PhD students Clara, Nivetha, and Anna about what #IDWGS means to them ⬇️ #WomenInScience
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The Institute of Cancer Research @icr.ac.uk · 10/02/2025
We’re delighted that The Scottish Medicines Consortium (SMC) has today recommended olaparib for use in advanced #BreastCancer. The treatment offers the chance of longer, healthier lives for people with breast cancer caused by faulty #BRCA1 or #BRCA2 genes. scottishmedicines.org.uk/about-us/lat...
scottishmedicines.org.uk
February 2025 decisions news release
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Sjors Scheres @sjorsscheres.bsky.social · 07/02/2025
Will these tools further exacerbate biases in the literature: if the opinion of those who write many papers gets fed into their training more than the opinion of those who write sparingly? Scientists should use their precious time to do good science, not to write many papers...
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Derek Lowe @dereklowe.bsky.social · 05/02/2025
I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War. Same link, new title and some updates.
science.org
Revised and Extended: What's Happening Inside the NIH and NSF
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Luke Taylor MP @luketaylorld.bsky.social · 27/01/2025
ICYMI The Institute of Cancer Research have made amazing inroads in treating advanced prostate cancer with the new NXP800 drug. So proud to represent the Institute - they embody the ambition and pursuit of pragmatic hope that Sutton, and the whole country, really needs.
buff.ly
Drug breakthrough offers hope for advanced prostate cancer patients
Research suggests a new drug slowed the growth of prostate cancer cells, including those with a resistance to the hormone therapy enzalutamide.
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Rob van Montfort @robvanmontfort.bsky.social · 31/01/2025
Looking forward to speak at the 2nd Biophysics for Drug Discovery Summit (ter.li/39kb11) about the integrated biophysical approaches used in our BCL6 project. Collaborative drug discovery with Swen Hoelder, @chemb.bsky.social and @temt-icr.bsky.social at @icrlondon.bsky.social.
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Rob van Montfort @robvanmontfort.bsky.social · 23/01/2025
We have a vacancy in assay development, compound profiling, and screening to help progress the cancer drug discovery projects of the Centre for Cancer Drug Discovery @icrlondon.bsky.social. If you are interested please check out the details below. jobs.icr.ac.uk/vacancies/11...
jobs.icr.ac.uk
Higher Scientific Officer - Assay development and compound profiling in Sutton | The Institute of Cancer Research
View details and apply for this Higher Scientific Officer - Assay development and compound profiling vacancy in Sutton. Salary : Commencement on the salary range is subject to comparable skil...
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Rob van Montfort @robvanmontfort.bsky.social · 22/01/2025
If you are interested in a PhD studentship in chemical biology linked to brain cancer in children, check out the position Gary Newton and myself have available. @icrlondon.bsky.social. www.icr.ac.uk/study-and-ca...
icr.ac.uk
Targeting SRC in G4-Medulloblastoma
OPEN: Targeting SRC in G4-Medulloblastoma
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Rob van Montfort @robvanmontfort.bsky.social · 03/01/2025
Beautiful and frosty morning @icrlondon.bsky.social today.
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Ben Bellenie @chemb.bsky.social · 20/12/2024
@cancerresearchuk.org Windsor Fellowship and Black in Cancer funded PhD place at @icrlondon.bsky.social and @imperialcollegeldn.bsky.social Aimed at students from Black heritage background who want to pursue a career in cancer research : www.findaphd.com/phds/project... (1/2)
findaphd.com
Design of advanced therapeutics against metastasis at Institute of Cancer Research on FindAPhD.com
PhD Project - Design of advanced therapeutics against metastasis at Institute of Cancer Research, listed on FindAPhD.com
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The Institute of Cancer Research @icr.ac.uk · 16/12/2024
🆕 We're getting in on the act with an ICR research #StarterPack. Check it out! ⤵️ Let us know if you're a #cancer researcher at the ICR and The Royal Marsden but not in the pack. 💬 #CancerResearch #CanSky #OncSky go.bsky.app/EGXU5V1
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Derek Lowe @dereklowe.bsky.social · 03/12/2024
That awkward moment when someone publishes a paper saying that they can’t find any evidence that your compounds bind to what your own series of papers say that they bind to. . .
science.org
Do They Even Bind?
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Rob van Montfort @robvanmontfort.bsky.social · 27/11/2024
Radiation damage to proteins in crystal structures is well studied but specific radiation damage to bound inhibitors is poorly documented. Pleased our study on "Specific radiation damage to halogenated inhibitors and ligands in protein crystal structures" is out now: doi.org/10.1107/S160...
doi.org
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Rob van Montfort @robvanmontfort.bsky.social · 25/11/2024
Stormy and bumpy flight yesterday to visit Alessio Ciulli and his CeTPD in Dundee.
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Rob van Montfort @robvanmontfort.bsky.social · 19/11/2024
It was a privilege to be part of this amazing fundraising initiative which will help us to make the discoveries to defeat cancer. Thanks to everyone who sponsored us!! If you missed your chance and still would like to do so check out this link: lnkd.in/gfy7EW9S
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