iiinova — where your digital self keeps evolving

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Science Magazine @science.org · 07/10/2026

This year’s Nobel Prize in Chemistry honors Henri Kagan of the Université Paris-Sud and Kenso Soai of Tokyo University of Science for providing clues to how life’s one-handed chemistry might have emerged. Learn more: scim.ag/3Vobwe7

Nobel Prize honors researchers who solved chemistry's asymmetry mystery
Henri Kagan and Kenso Soai win award for reactions leading to one-handed molecules

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UW–Madison @uwmadison.bsky.social · 06/10/2026

Congratulations to Francis Halzen, UW–Madison professor of physics and principal investigator of @icecubeneutrino.bsky.social, on being named the 2026 Nobel Laureate in physics. His work helped unlock new ways of understanding the universe and the particles known as neutrinos. @nobelprize.org

news.wisc.edu

University of Wisconsin–Madison Professor Francis Halzen named 2026 Nobel laureate in physics

Halzen is the principal investigator of the IceCube Neutrino Observatory, the world’s largest telescope.

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Max Waugh @maxwaughphoto.bsky.social · 17/07/2026

The Yellowstone theme is the one calendar I've been publishing every year since 2006. Thankfully, I have yet to run out of images. Here are a few of the pages...

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Jeremy Berg @jeremymberg.bsky.social · 25/09/2026

My quote of the day I've always been a practical person, not one to waste time pursuing unrealistic goals or dreams. But today's dreams can soon become tomorrow's reality in biomedical research. Christopher Reeve

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Taylor Mitchell Brown @tmitchellbrown.bsky.social · 22/09/2026

Scientists in California just discovered a record-breaking “fire amoeba” that can endure temperatures hotter than any other complex life. The researchers found part of its hardy nature comes from positively charged proteins that act as a protective blanket. #FireAmoeba 🧪🧪 New at @science.org

science.org

How the ‘fire amoeba’ withstands temperatures that would kill most complex life

Incendiamoeba cascadensis may survive in volcanic lakes thanks to a static blanket that shields its proteins from the heat

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Alt National Park Service @altnps.bsky.social · 05/09/2026

The title really says it all.

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In Otter News @in-otter-news.bsky.social · 24/08/2026

They grow up so fast!

Steve the otter is shown in a two‐panel comparison—with him as a tiny pup in 2014 and as a larger otter in 2026—each curled up on the same shark plush toy against a soft, homey background.
Text in image: “2014” (top panel), “2026” (bottom panel).

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Science Magazine @science.org · 10/08/2026

In the DNA of bison, scientists find clues to the animals’ past—and keys to safeguarding their future. Learn more: scim.ag/4bHkyYS

Illustration comparing a plains bison and wood bison. The wood bison has a taller, squarer hump, while the plains bison's hump is more rounded. The plains bison has a distinct cape demarcation in summer, with a furry cape which is lighter in color than its body. The plains bison has frizzy hair on its head, as compared to the wood bison's long straight hair. The plains bison also has a shorter tail, longer shaggy chap hair, and a larger beard and throat mane.

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Eric Topol @erictopol.bsky.social · 21/08/2026

Where we're headed......

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Eric Topol @erictopol.bsky.social · 13/08/2026

"government overreach designed to disconnect citizens from the truth and advance an authoritarian agenda" "must recognize how critically linked science is to democracy itself and defend its integrity with every tool at their disposal." @science.org www.science.org/doi/10.1126/...

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Lezanne Ooi @lezanne.bsky.social · 12/08/2026

If you know someone that will be in Brisbane next week on Wednesday 19th August / is interested in #scicomm / #neuroscience / #DnD / #DungeonsandDragons / #improv / #comedy then please share this event! tickets.oztix.com.au/outlet/event... @arcqubic.bsky.social @mind-adcre.bsky.social

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Eric Topol @erictopol.bsky.social · 12/08/2026

By the WSJ editorial board www.wsj.com/opinion/dona...

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 30/07/2026

“If the government hadn’t funded research into desert lizard venom, we wouldn’t know about semaglutide…If research scientists hadn’t studied how bees optimize nectar foraging within a colony, we wouldn’t have the algorithm that assigns internet traffic” www.publicnotice.co/p/michael-kr...

publicnotice.co

The new "science golden age" looks suspiciously like a grift

Trump wants to run scientific research like his family business.

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Karolin Luger @nucleosomepolice.bsky.social · 27/07/2026

'sound dampening devices' for the Duchess (aka Glacios) finally in place. Yes thats what we are calling them. Also, didnt want the Duchess to be jealous of Princess Krios's chambers #quilting #cryoEM

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Barb Golden @barbgolden.bsky.social · 22/07/2026

👀👀👀! New paper online @pnas.org shows that a polymerase ribozyme can copy an RNA with higher precision when the conditions support backtracking. This "chew-back" corrects mistakes and repairs dead-ends, leading to longer, higher-fidelity copies. www.pnas.org/doi/full/10....

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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c0nc0rdance @c0nc0rdance.bsky.social · 22/07/2026

This 2012 electron microscope video is from James Tyrwhitt-Drake, a scientist at University of Victoria’s Advanced Microscopy Facility. In order, you're looking at: An amphipod (~5 mm = 5000 microns) A diatom (50 microns) A bacteria (1 micron). Life at every scale! (📷: James Tyrwhitt-Drake)

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Karen Fisher, PhD @fisherke.bsky.social · 19/07/2026

My dad has frequently commented on the importance of recruiting foreign scientists to the US. His data point - the last names on patent applications.

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FrontRangeWildflowers @frwildflowers.bsky.social · 02/07/2026

Colorado Blue Columbine on Clear Creek today #nativeplants 🌿

Blue and white columbine flower with numerous yellow stamens

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Kevin Gardner @nmrkaygee.bsky.social · 29/06/2026

Excellent NYT opinion piece highlighting the past scientific contributions of something many Americans know – the Lewis & Clark expedition – to parallels in modern day science, including the need for proper support of long-term, ambitious aims. Free link: www.nytimes.com/2026/06/28/o...

nytimes.com

Opinion | Trump Could Learn a Thing or Two From Thomas Jefferson

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Jens Schmidt @jenscs83.bsky.social · 23/06/2026

Out today in Molecular Cell! Lead by Mariia Mikhova and in collaboration with Kefei Yu’s lab @msumgi.bsky.social we dug into the molecular mechanism of class switch recombination in B cells using simultaneous RNA and protein single-molecule imaging. 1/n www.cell.com/molecular-ce...

cell.com

A dynamic RNA hub facilitates activation-induced cytidine deaminase recruitment to the immunoglobulin heavy-chain locus

Mikhova et al. used live-cell single-molecule imaging to track the nuclear dynamics of AID and switch region transcription in B cells undergoing class switch recombination and discovered an RNA hub fo...

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Eric Topol @erictopol.bsky.social · 22/06/2026

Two of the most important biomedical breakthroughs came from science of the Gila lizard venom (GLP-1s) and yogurt (CRISPR genome editing). "The system that turned that lizard into a medicine is now being dismantled." gift link nytimes.com/2026/06/20/o...

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Karolin Luger @nucleosomepolice.bsky.social · 20/06/2026

Please share this gift article from The New York Times with friends, family, sceptics, and People who think that studying weird things is a waste of money. Then follow up with meaningful discussion about what I call 'free range science'. Free without subscription. www.nytimes.com/2026/06/20/o...

nytimes.com

Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack

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Rep. Dr. Jasmine Clark @jasmineclarkforga.bsky.social · 17/06/2026

When I head to Washington, I will be the first woman in Congress with a science PhD. That matters. At a time when science is under attack, Congress needs more leaders who understand the value of evidence-based decision-making.

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Telomerase_Scott Cohen @telomerase-cmri.bsky.social · 15/06/2026

Always a thrill to be back at Molecular Horizons Institute (University of Wollongong) to image my Lovely on Captain Krios.

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Derek Lowe @dereklowe.bsky.social · 28/05/2026

An unapologetically angry post about what’s being done to US science:

science.org

The Current Crisis: What's Happening to Science in America

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Mark Peifer (He, him) @peiferlabunc.bsky.social · 13/05/2026

While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪

https://www.nature.com/articles/s41586-025-10004-2
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC

U. Sahin, M. Schmidt, E. Derhovanessian, A. Cortini, I. Vogler, T. Omokoko, E. Godehardt, S. Attig, S. Newrzela, J. Grützner, N. Bidmon, S. Bolte, S. Brachtendorf, T. Stuhlmann, D. Langer, D. Brüne, J. Blake, A. Feldner, H. Lindman, A. Schneeweiss, M. Eichbaum & Ö. Türeci
Triple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. Here we assessed an individualized neoantigen mRNA vaccine in 14 patients with TNBC following surgery and after neoadjuvant or adjuvant therapy. In peripheral blood of nearly all patients, high-magnitude, vaccine-induced, mostly de novo T cell responses to multiple neoantigens were detected that remained functional for several years. Characterization of individual patients revealed that a large proportion of these T cells developed into two subsets: a late-differentiated phenotype with markers indicative of ‘ready-to-act’ cytotoxic effector T cells, and T cells with a stem cell-like memory phenotype. Eleven patients remained relapse-free for up to six years post-vaccination. Recurrence occurred in three patients: the individual with the weakest vaccine-induced T cell response relapsed, but achieved complete remission on subsequent anti-PD-1 therapy; another patient had a tumour with low major histocompatibility complex (MHC) class I expression with MHC class I-deficient cells growing out under vaccination; and the third patient was BRCA-positive and had a recurrence from a genetically distinct primary tumour. These findings demonstrate the feasibility of individualized RNA vaccines in TNBC, document persistence of vaccine-induced, functional neoantigen-specific T cells and provide insights into possible immune escape mechanisms that will guide future approaches.

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Jake Yeston @jakeyeston.bsky.social · 07/05/2026

From Joelle Pelletier and Rebecca Buller in the Perspective "...seven engineered and three auxiliary enzymes, including industrially atypical enzyme classes...which each required extensive engineering (more than 50 mutations per enzyme on average)" www.science.org/doi/10.1126/...

science.org

Building an oral peptide drug

Engineered enzymes enable kilogram-scale synthesis of drug for high-cholesterol conditions

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Bethany Halford @bethanyhalford.bsky.social · 07/05/2026

Biocatalysts can build big molecules. A team at Merck & Co. developed a suite of enzymes that stitch together their oral PCSK9 inhibitor enlicitide. My latest for @cenmag.bsky.social cen.acs.org/pharmaceutic... #chemsky

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 08/05/2026

Did you know that Pierre Chambon's laboratory was the first to use the term "nucleosome" in 1975 ? www.cell.com/cell/fulltex...

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Eric Topol @erictopol.bsky.social · 12/04/2026

The turning point for rare diseases, which affect >300 million people around the world. A call to get rid of its many structural obstacles, to consider it as molecular surgery unlike drug treatments gift link: www.nytimes.com/2026/04/09/o...

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Karolin Luger @nucleosomepolice.bsky.social · 11/04/2026

i am sick and tired of dumb old white men with reptilian brains (three examples below) making bad decisions that impact all of us.

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Richard Sever @richardsever.bsky.social · 11/04/2026

Nobel Laureate Jack Szostak “This country has given me endless opportunities…: The America we inhabit today bears almost no resemblance to the country I chose all those years ago” newsletter.ofthebrave.org/p/im-a-nobel...

newsletter.ofthebrave.org

I’m a Nobel Prize-winning immigrant. I can no longer recognize this country.

Attacks on science and immigrants are destroying America.

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Bill Kristol @billkristolbulwark.bsky.social · 10/04/2026

"All of these things frighten me, and they should frighten you as well. I made the decision to create a life for myself here, because I viewed this as a place that rewarded determination, hard work, and integrity. It still has a chance to be that place again." open.substack.com/pub/ofthebra...

open.substack.com

I’m a Nobel Prize-winning immigrant. I can no longer recognize this country.

Attacks on science and immigrants are destroying America.

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Alex Spahn 🌋🌪️☄️ @spahn711.bsky.social · 07/04/2026

Waking up to the awe-inspiring images from NASA at the same time the US President is implying that he will commit genocide, I can't think of a better quote for the times than this one from Apollo astronaut Edgar Mitchell. I added it to today's Earthset image:

“You develop an instant global consciousness, a people orientation, an intense dissatisfaction with the state of the world, and a compulsion to do something about it. From out there on the moon, international politics look so petty. You want to grab a politician by the scruff of the neck and drag him a quarter of a million miles out and say, ‘Look at that, you son of a bitch.”
― Edgar Mitchell

Image: Earthset captured through the Orion spacecraft window at 6:41 p.m. EDT, April 6, 2026, during the Artemis II crew’s flyby of the Moon. A muted blue Earth with bright white clouds sets behind the cratered lunar surface.
The dark portion of Earth is experiencing nighttime. On Earth’s day side, swirling clouds are visible over the Australia and Oceania region.
In the foreground, Ohm crater has terraced edges and a flat floor interrupted by central peaks. Central peaks form in complex craters when the lunar surface, liquefied on impact, splashes upwards during the crater’s formation.

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Telomerase_Scott Cohen @telomerase-cmri.bsky.social · 22/03/2026

Indulged in a distraction from it all… Just once or twice a year one can experience the massive organ in the Sydney Opera House. Organist ANNA LAPWOOD.

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Tony Cesare @thecesarelab.bsky.social · 18/03/2026

An important seasonal installation in the Cesare lab. March Madness bracket is up. Go Tar Heels! 🏀

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Dr Monique Ryan @mon4kooyong.bsky.social · 09/03/2026

More than 60% of Australian medical researchers left active research roles between 2019 & 2024 because they could not make ends meet - while my costings from the PBO suggest the govt could more than double annual spending from the MRFF without any effect on its base level of funding.

abc.net.au

Up to $1.4 billion in medical research remains unused under government cap

Researchers say securing funding has become increasingly tough, with many left with no choice but to spend a disproportionate amount of time applying for grants.

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Eric Topol @erictopol.bsky.social · 26/02/2026

And the Lancet's editorial that goes with it www.thelancet.com/journals/lan...

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Andrew Freedman @afreedma.bsky.social · 13/02/2026

New: Trump admin moves to pull supercomputing center out of top weather and climate research center (NCAR) in Boulder, Colo. Part of its effort to "break up" the lab. www.cnn.com/2026/02/13/w...

cnn.com

Trump admin is pulling supercomputers out of key weather research center | CNN

A leading American research lab is slated to lose its critical supercomputing facility, according to a letter released Thursday by the National Science Foundation.

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Brenda Bass @bbass.bsky.social · 14/02/2026

So, so, honored by this award—it is daunting to know that my heroes have won this award! Thanks to my heroes and mentors, and my trainees, who are everything!!!!

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Karolin Luger @nucleosomepolice.bsky.social · 16/02/2026

it looks as shiny and wonderful as the day you made it!

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Karolin Luger @nucleosomepolice.bsky.social · 12/02/2026

another stunning piece by the amazing and uninimitable @bryanwelm.bsky.social . I would recognize his pieces anywhere!

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